MIR-29A-3P, MIR-29C-3P, MIR-146B-5P AND MIR-150-5P, Their Target Genes and lncrnas in HIV Infection: A Bioinformatic Study.

IF 0.8 4区医学 Q4 IMMUNOLOGY Current HIV Research Pub Date : 2023-01-01 DOI:10.2174/1570162X21666230524151328

Maria Rosaria Tumolo, Egeria Scoditti, Roberto Guarino, Tiziana Grassi, Francesco Bagordo, Saverio Sabina

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Abstract

Introduction: Increasing evidence suggests that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have emerged as attractive targets in viral infections, including Human immunodeficiency virus (HIV).

Objective: To deepen the understanding of the molecular mechanisms that lead to HIV and provide potential targets for the future development of molecular therapies for its treatment.

Methods: Four miRNAs were selected as candidates based on a previous systematic review. A combination of bioinformatic analyses was performed to identify their target genes, lncRNAs and biological processes that regulate them.

Results: In the constructed miRNA-mRNA network, 193 gene targets are identified. These miRNAs potentially control genes from several important processes, including signal transduction and cancer. LncRNA-XIST, lncRNA-NEAT1 and lncRNA-HCG18 interact with all four miRNAs.

Conclusion: This preliminary result forms the basis for improving reliability in future studies to fully understand the role these molecules and their interactions play in HIV.

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MIR-29A-3P, MIR-29C-3P, MIR-146B-5P和MIR-150-5P及其靶基因和lncrna在HIV感染中的生物信息学研究

越来越多的证据表明，microRNAs (miRNAs)和长链非编码rna (lncRNAs)已成为病毒感染(包括人类免疫缺陷病毒(HIV))中有吸引力的靶点。目的:加深对HIV分子机制的认识，为未来分子疗法的发展提供潜在靶点。方法:基于先前的系统评价，选择了四个mirna作为候选mirna。结合生物信息学分析来鉴定它们的靶基因、lncrna和调控它们的生物过程。结果:在构建的miRNA-mRNA网络中，共鉴定出193个基因靶点。这些mirna可能控制几个重要过程中的基因，包括信号转导和癌症。LncRNA-XIST、lncRNA-NEAT1和lncRNA-HCG18与这四种mirna相互作用。结论:这一初步结果为进一步研究这些分子及其相互作用在HIV中的作用奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.