Pub Date : 2024-11-12DOI: 10.2174/011570162X317921241009083357
Zhen-Hua Li, Bao-Jiang Xie, Wei Yi, Li Li, Ya-Xian Wei, Nuo Yi, Li-Hong Lu
Objective: The aim of the study was to assess the clinical features of women infected with the human immunodeficiency virus (HIV) using Holter monitoring.
Methods: Thirty-five female patients infected with HIV using a Holter monitor at the Ditan Hospital were retrospectively analyzed.
Results: In terms of basic rhythms, there were 30 cases of sinus rhythm, 27 cases of ventricular premature beat, 26 cases of supraventricular premature beat, 12 cases of mild reduction of HRV, 9 cases of normal heart rate variability (HRV), 8 cases of supraventricular tachycardia, 5 cases of abnormal ST-segment changes and 2 cases of sinus bradycardia 2 cases of paroxysmal atrial fibrillation 2 cases of junctional escape rhythm. There was only one case in each of the following ECG changes: persistent atrial fibrillation, sinus tachycardia, couplet supraventricular premature beats, accelerated idioventricular rhythm, sinoatrial block, second-degree Mobitz type I atrioventricular block, second-degree Mobitz type II atrioventricular block, complete right bundle branch block, T-wave abnormality, and significant reduction of HRV.
Conclusion: The Holter monitor can show more changes in the electrocardiogram (ECG) of HIV-- positive patients, particularly significant ECG abnormalities, such as paroxysmal atrial fibrillation, and can direct early clinical treatment to serious adverse results.
研究目的该研究旨在通过Holter监测评估感染人类免疫缺陷病毒（HIV）的女性患者的临床特征：方法：对地坛医院使用 Holter 监测仪的 35 例女性艾滋病感染者进行回顾性分析：在基本节律方面，窦性心律30例，室性早搏27例，室上性早搏26例，心率变异轻度减低12例，心率变异正常9例，室上性心动过速8例，ST段异常改变5例，窦性心动过缓2例，阵发性心房颤动2例，交界性逸搏心律2例。以下心电图变化各仅有 1 例：持续性心房颤动、窦性心动过速、对偶室上性早搏、加速性室性心律、中房传导阻滞、二度 Mobitz I 型房室传导阻滞、二度 Mobitz II 型房室传导阻滞、完全性右束支传导阻滞、T 波异常、心率变异显著减弱：结论：Holter 监测仪可显示 HIV 阳性患者心电图的更多变化，尤其是明显的心电图异常，如阵发性心房颤动，可指导早期临床治疗，避免严重不良后果的发生。
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Introduction: People living with HIV (PLHIV) suffer from a range of consequences related to infection, including hyperlipidemia and neurologic and sleep disorders. Supplements containing phenolic compounds with high antioxidant properties can reduce these side effects. Resveratrol is a phenolic compound that improves the symptoms of diabetes, cancer, and viral infections. This study aimed to evaluate the effects of resveratrol on hyperlipidemia and neurological problems in PLHIV in Iran.
Method: In this double-blind, randomized clinical trial, 41 PLHIV were randomly assigned to two groups: a placebo group (n=21) and a resveratrol group (n=20). Triglyceride and cholesterol levels were determined for all the subjects before and one month after they used the medication. Additionally, standard questionnaires were used to evaluate the quality of sleep, stress, depression, and quality of life of the participants. The data were analyzed via analysis of covariance in Stata 17.0.
Results: The study population did not significantly differ in terms of age (p=0.49), sex (p=0.09), marital status (p=0.90), level of education (p=0.90), duration of HIV infection (p=0.54), or mode of HIV transmission (p=0.51). The administration of resveratrol did not affect psychological parameters or blood cholesterol (p=0.091) or triglyceride (p=0.932) levels.
Conclusion: The administration of resveratrol did not affect cholesterol or triglyceride levels or the rates of depression, anxiety, sleep quality, or quality of life in PLHIV. The resveratrol supplementation in a large-scale clinical study involving more patients for a longer course of treatment may have had more significant effects on the serum levels of lipids and psychological factors.
导言：艾滋病病毒感染者（PLHIV）患有一系列与感染有关的后遗症，包括高脂血症、神经和睡眠障碍。含有高抗氧化性酚类化合物的保健品可以减轻这些副作用。白藜芦醇是一种酚类化合物，可改善糖尿病、癌症和病毒感染的症状。本研究旨在评估白藜芦醇对伊朗 PLHIV 患者高脂血症和神经系统问题的影响：在这项双盲随机临床试验中，41 名 PLHIV 被随机分配到两组：安慰剂组（21 人）和白藜芦醇组（20 人）。在用药前和用药一个月后，对所有受试者的甘油三酯和胆固醇水平进行测定。此外，还使用标准问卷对受试者的睡眠质量、压力、抑郁和生活质量进行了评估。数据通过 Stata 17.0 进行协方差分析：研究人群在年龄（P=0.49）、性别（P=0.09）、婚姻状况（P=0.90）、教育程度（P=0.90）、HIV 感染持续时间（P=0.54）或 HIV 传播方式（P=0.51）方面没有明显差异。服用白藜芦醇不会影响心理参数或血液胆固醇（p=0.091）或甘油三酯（p=0.932）水平：服用白藜芦醇不会影响胆固醇或甘油三酯水平，也不会影响 PLHIV 的抑郁、焦虑、睡眠质量或生活质量。在涉及更多患者、疗程更长的大规模临床研究中补充白藜芦醇可能会对血清中的血脂水平和心理因素产生更显著的影响。
{"title":"The Effects of Resveratrol in a Randomized Clinical Trial on Drug-Induced Hyperlipidemia and Psychiatric Factors in People Living with HIV.","authors":"Bahar Ahmadi-Mousavi, Somayyeh Karami-Mohajeri, Fatemeh Dabaghzadeh, Motahareh Soltani, Zohreh Oghabian, Hamid Sharifi","doi":"10.2174/011570162X301403241104043813","DOIUrl":"https://doi.org/10.2174/011570162X301403241104043813","url":null,"abstract":"<p><strong>Introduction: </strong>People living with HIV (PLHIV) suffer from a range of consequences related to infection, including hyperlipidemia and neurologic and sleep disorders. Supplements containing phenolic compounds with high antioxidant properties can reduce these side effects. Resveratrol is a phenolic compound that improves the symptoms of diabetes, cancer, and viral infections. This study aimed to evaluate the effects of resveratrol on hyperlipidemia and neurological problems in PLHIV in Iran.</p><p><strong>Method: </strong>In this double-blind, randomized clinical trial, 41 PLHIV were randomly assigned to two groups: a placebo group (n=21) and a resveratrol group (n=20). Triglyceride and cholesterol levels were determined for all the subjects before and one month after they used the medication. Additionally, standard questionnaires were used to evaluate the quality of sleep, stress, depression, and quality of life of the participants. The data were analyzed via analysis of covariance in Stata 17.0.</p><p><strong>Results: </strong>The study population did not significantly differ in terms of age (p=0.49), sex (p=0.09), marital status (p=0.90), level of education (p=0.90), duration of HIV infection (p=0.54), or mode of HIV transmission (p=0.51). The administration of resveratrol did not affect psychological parameters or blood cholesterol (p=0.091) or triglyceride (p=0.932) levels.</p><p><strong>Conclusion: </strong>The administration of resveratrol did not affect cholesterol or triglyceride levels or the rates of depression, anxiety, sleep quality, or quality of life in PLHIV. The resveratrol supplementation in a large-scale clinical study involving more patients for a longer course of treatment may have had more significant effects on the serum levels of lipids and psychological factors.</p>","PeriodicalId":10911,"journal":{"name":"Current HIV Research","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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