Xu Zhang, Fang-Zhi Du, Qian-Qiu Wang, Rui-Li Zhang
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引用次数: 0
Abstract
We conducted a systematic review to analyse the consistency of nontreponemal-specific tests of Treponema pallidum in cerebrospinal fluid. We searched the PubMed, EMBASE, Web of Science, CNKI, Wanfang and Chongqing VIP databases. The inclusion criteria were studies conducted on nontreponemal-specific tests in cerebrospinal fluid (CSF) within the same population. Exclusion criteria were studies with incomplete data or where we were unable to obtain the full text, duplicate reports, case reports and studies without sensitivity or specificity results. We used kappa value analysis and McNemar's test to analyse study consistency. We initially collected a total of 198 articles and ultimately included six articles that involved 429 patients with neurosyphilis. The performance between venereal disease research laboratory tests (VDRL) and the reactive plasma regain or toluidine red serum unheated test was similar. The kappa value for consistency between VDRL and reactive plasma regain was >0.8 in three articles, and was 0.892 for consistency between VDRL and toluidine red serum unheated test in one article. Our results suggested that CSF-reactive plasma regain or CSF-toluidine red serum unheated test may serve as alternative tests in the diagnosis of neurosyphilis with CSF-VDRL.
我们进行了一项系统综述,以分析脑脊液中苍白螺旋体的非特异性测试的一致性。我们搜索了PubMed、EMBASE、Web of Science、CNKI、万方和重庆VIP数据库。纳入标准是在同一人群中对脑脊液(CSF)中的非特异性测试进行的研究。排除标准是数据不完整的研究,或者我们无法获得全文、重复报告、病例报告和没有敏感性或特异性结果的研究。我们使用kappa值分析和McNemar检验来分析研究的一致性。我们最初总共收集了198篇文章,最终包括6篇涉及429名神经梅毒患者的文章。性病研究实验室测试(VDRL)和反应性血浆回潮或甲苯胺红血清未加热测试之间的表现相似。在三篇文章中,VDRL和反应性血浆回潮之间一致性的kappa值>0.8,在一篇文章中VDRL和甲苯胺红血清未加热试验之间一致性为0.892。我们的结果表明,CSF反应性血浆恢复或CSF甲苯胺红血清未加热试验可作为诊断CSF-VDRL神经梅毒的替代试验。
期刊介绍:
Sexual Health publishes original and significant contributions to the fields of sexual health including HIV/AIDS, Sexually transmissible infections, issues of sexuality and relevant areas of reproductive health. This journal is directed towards those working in sexual health as clinicians, public health practitioners, researchers in behavioural, clinical, laboratory, public health or social, sciences. The journal publishes peer reviewed original research, editorials, review articles, topical debates, case reports and critical correspondence.
Officially sponsored by:
The Australasian Chapter of Sexual Health Medicine of RACP
Sexual Health Society of Queensland
Sexual Health is the official journal of the International Union against Sexually Transmitted Infections (IUSTI), Asia-Pacific, and the Asia-Oceania Federation of Sexology.