Cost-effectiveness of extended DPYD testing before fluoropyrimidine chemotherapy in metastatic breast cancer in the UK.

IF 1.7 4区医学 Q3 PHARMACOLOGY & PHARMACY Personalized medicine Pub Date : 2023-07-01 Epub Date: 2023-09-04 DOI:10.2217/pme-2022-0099

Rositsa Koleva-Kolarova, Heleen Vellekoop, Simone Huygens, Matthijs Versteegh, Maureen Rutten-van Mölken, László Szilberhorn, Tamás Zelei, Balázs Nagy, Sarah Wordsworth, Apostolos Tsiachristas

引用次数: 2

Abstract

The aim of this study was to evaluate the cost-effectiveness of ToxNav^©, a multivariant genetic test, to screen for DPYD followed by personalized chemotherapy dosing for metastatic breast cancer in the UK compared with no testing followed by standard dose, standard of care. In the main analysis, ToxNav was dominant over standard of care, producing 0.19 additional quality-adjusted life years and savings of £78,000 per patient over a lifetime. The mean additional quality-adjusted life years per person from 1000 simulations was 0.23 savings (95% CI: 0.22-0.24) at £99,000 (95% CI: £95-102,000). Varying input parameters independently by range of 20% was unlikely to change the results in the main analysis. The probabilistic sensitivity analysis showed ~97% probability of the ToxNav strategy to be dominant.

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英国癌症转移性乳腺癌氟嘧啶化疗前延长DPYD试验的成本效益。

本研究的目的是评估ToxNav©（一种多变量基因测试）的成本效益，以筛选英国转移性乳腺癌症的DPYD，然后进行个性化化疗剂量，与未进行测试，然后进行标准剂量、标准护理相比。在主要分析中，ToxNav在标准护理中占主导地位，为每位患者带来了0.19个额外的质量调整生命年，并在一生中节省了78000英镑。从1000次模拟中，每人平均额外的质量调整寿命为0.23年（95%置信区间：0.22-0.24），为99000英镑（95%置信度：95-102000英镑）。在20%的范围内独立改变输入参数不太可能改变主分析的结果。概率敏感性分析显示ToxNav策略占主导地位的概率约为97%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Personalized medicine 医学-药学

CiteScore

3.30

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis. The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.