Treatment of Pediatric Eosinophilic Esophagitis: Traditional and Novel Therapies.

Q1 Medicine Current Gastroenterology Reports Pub Date : 2023-11-01 Epub Date: 2023-09-02 DOI:10.1007/s11894-023-00893-6

Colby S Sharlin, Vincent A Mukkada, Philip E Putnam, Scott M Bolton

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Abstract

Purpose of review: This review presents and summarizes the existing studies on the treatment goals and options for pediatric eosinophilic esophagitis utilizing rigorous peer-reviewed literature.

Recent findings: In addition to traditional treatments, emerging biologic therapies continue to evolve the approach to treating pediatric eosinophilic esophagitis. Well defined treatment goals will aid the continued development of new therapies. Further, innovative assessment tools have changed how the clinician is able to assess the effectiveness of therapies with a trend toward less invasive options. The management of pediatric eosinophilic esophagitis continues to evolve with the advent of both novel treatment options and assessment tools. Treatment choices, with benefits and risks involved, should be presented to families upon diagnosis and tailored towards the individual patient and likelihood of adherence and success. Biologic therapy for EoE presents an exciting option for both first line therapy and escalation for those with severe or unresponsive disease.

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儿童嗜酸性粒细胞性食管炎的治疗:传统与新疗法。

综述目的:本综述利用严格的同行评议文献，介绍并总结了关于儿童嗜酸性粒细胞性食管炎的治疗目标和选择的现有研究。最新发现:除了传统的治疗方法外，新兴的生物疗法继续发展治疗儿童嗜酸性粒细胞性食管炎的方法。明确的治疗目标将有助于新疗法的持续发展。此外，创新的评估工具已经改变了临床医生评估治疗效果的方式，其趋势是更少的侵入性选择。随着新的治疗方案和评估工具的出现，儿童嗜酸性粒细胞性食管炎的治疗不断发展。治疗选择，包括益处和风险，应在诊断后提交给家庭，并针对个别患者以及坚持和成功的可能性进行调整。对于那些严重或无反应性疾病的患者，生物治疗为一线治疗和升级提供了一个令人兴奋的选择。

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来源期刊

Current Gastroenterology Reports Medicine-Gastroenterology

CiteScore

7.80

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0.00%

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期刊介绍： As the field of gastroenterology and hepatology rapidly evolves, the wealth of published literature can be overwhelming. The aim of the journal is to help readers stay abreast of such advances by offering authoritative, systematic reviews by leading experts. We accomplish this aim by appointing Section Editors who invite international experts to contribute review articles that highlight recent developments and important papers published in the past year. Major topics in gastroenterology are covered, including pediatric gastroenterology, neuromuscular disorders, infections, nutrition, and inflammatory bowel disease. These reviews provide clear, insightful summaries of expert perspectives relevant to clinical practice. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.

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