Stimuli-responsive biomaterials: smart avenue toward 4D bioprinting.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-07-13 DOI:10.1080/07388551.2023.2213398
Maedeh Rahimnejad, Sepideh Jahangiri, Shahrzad Zirak Hassan Kiadeh, Seyedkamaladdin Rezvaninejad, Zarrin Ahmadi, Sepideh Ahmadi, Moein Safarkhani, Navid Rabiee
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引用次数: 0

Abstract

3D bioprinting is an advanced technology combining cells and bioactive molecules within a single bioscaffold; however, this scaffold cannot change, modify or grow in response to a dynamic implemented environment. Lately, a new era of smart polymers and hydrogels has emerged, which can add another dimension, e.g., time to 3D bioprinting, to address some of the current approaches' limitations. This concept is indicated as 4D bioprinting. This approach may assist in fabricating tissue-like structures with a configuration and function that mimic the natural tissue. These scaffolds can change and reform as the tissue are transformed with the potential of specific drug or biomolecules released for various biomedical applications, such as biosensing, wound healing, soft robotics, drug delivery, and tissue engineering, though 4D bioprinting is still in its early stages and more works are required to advance it. In this review article, the critical challenge in the field of 4D bioprinting and transformations from 3D bioprinting to 4D phases is reviewed. Also, the mechanistic aspects from the chemistry and material science point of view are discussed too.

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刺激响应型生物材料:实现 4D 生物打印的智能途径。
三维生物打印是一种先进的技术,它将细胞和生物活性分子结合在一个单一的生物支架中;然而,这种支架无法随着动态实施环境的变化而改变、修改或生长。最近,智能聚合物和水凝胶进入了一个新时代,它们可以为三维生物打印技术增加另一个维度,例如时间维度,以解决当前方法的一些局限性。这一概念被称为 4D 生物打印。这种方法可以帮助制造具有模仿天然组织的构造和功能的类组织结构。尽管 4D 生物打印技术仍处于早期阶段,还需要更多的工作来推动它的发展,但这些支架可以随着组织的变化而变化和改造,并有可能释放出特定的药物或生物分子,用于生物传感、伤口愈合、软机器人、药物输送和组织工程等各种生物医学应用。本综述文章回顾了 4D 生物打印领域的关键挑战以及从 3D 生物打印到 4D 阶段的转变。此外,还从化学和材料科学的角度讨论了机理方面的问题。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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