Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Sudan.

IF 2 4区 生物学 Q4 MICROBIOLOGY Polish Journal of Microbiology Pub Date : 2023-09-20 eCollection Date: 2023-09-01 DOI:10.33073/pjm-2023-026
Ehssan H Moglad, Ahmed O Hassan, Mawada S Atta Elmanan, Samar M Saeed, Wafaa Mohammed Abdalla, Kawthar Abdelgaleil Mohammedsalih, Hatim T Ali, Mohammed Siddig Abd Elaziz, Hind Haidar Ahmed
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Abstract

Human Cytomegalovirus (HCMV) is a leading healthcare problem associated with stillbirth and congenital abnormalities. Determining the seroprevalence and the possible risk factors related to HCMV infections may be a cornerstone in preventing its complications. This cross-sectional study was conducted in Kassala and River Nile States to determine the seroprevalence and risk factors associated with HCMV infection in pregnant women. One hundred eighty-four (n = 184) blood specimens were collected from pregnant women from February 2018 to January 2020. Enzyme-linked immunosorbent assay (ELISA) was used to detect HCMV-specific IgG and IgM antibodies. Socio-demographical characteristics of the women were collected using structured questionnaires. The results showed that HCMV IgG was detected in 170 (92.4%) of the blood specimens, and IgM was detected in 29/93 (31.2%). There was a significant relationship between the history of miscarriage and the presence of IgG and IgM with a p-value = 0.001 and between HCMV IgM and gestational stage (p-value = 0.028). The study found a strikingly high seroprevalence of HCMV infections among pregnant women in the investigated States. This high percentage of illiterate housewives living in rural areas makes it possible to reduce the incidence of HCMV infection in pregnant women by improving their knowledge, attitude, and practice regarding the route of viral transmission, which may reflect in lowering the rate of congenital diseases in their infants.

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苏丹孕妇巨细胞病毒感染的血清流行病学调查。
人类巨细胞病毒(HCMV)是与死胎和先天性畸形相关的主要医疗保健问题。确定HCMV感染的血清流行率和可能的风险因素可能是预防其并发症的基石。这项横断面研究在卡萨拉州和尼罗河州进行,以确定孕妇HCMV感染的血清流行率和风险因素。2018年2月至2020年1月,从孕妇身上采集了一百八十四份(n=184)血样。酶联免疫吸附试验(ELISA)用于检测HCMV特异性IgG和IgM抗体。使用结构化问卷收集了这些妇女的社会人口学特征。结果显示170例(92.4%)血液标本中检出HCMV IgG,IgM检出率为31.2%。流产史与IgG和IgM的存在之间存在显著关系(p值=0.001),HCMV IgM与妊娠期之间存在显著相关性(p值0.028)。研究发现,在调查州孕妇中,HCMV感染的血清流行率非常高。生活在农村地区的文盲家庭主妇比例很高,这使得有可能通过提高她们对病毒传播途径的知识、态度和实践来降低孕妇感染HCMV的发病率,这可能反映在降低婴儿先天性疾病的发病率上。
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来源期刊
CiteScore
3.70
自引率
4.80%
发文量
41
审稿时长
2 months
期刊介绍: Polish Journal of Microbiology (PJM) publishes original research articles describing various aspects of basic and applied microbiological research. We are especially interested in articles regarding - basic biological properties of bacteria and archaea, viruses, and simple - eukaryotic microorganisms - genetics and molecular biology - microbial ecology - medical bacteriology and public health - food microbiology - industrial microbiology - bacterial biotechnology
期刊最新文献
Comparative Study of Linezolid and Vancomycin Regimens in One-Stage Surgery for Treating Limb Traumatic Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus. Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Sudan. The Pathogen Isolates in Chronic Wound Infections in Poland. Interaction of Biochemical Processes between Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Arterial Hypertension (PAH), and Coronavirus Disease 2019 (COVID-19). Antimicrobial Resistance and Biofilm Formation of Staphylococcus aureus Isolates from Febrile Cases: Findings from a Rural Cohort of Odisha, India.
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