Influences of Aged Bone Marrow Macrophages on Skeletal Health and Senescence.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Current Osteoporosis Reports Pub Date : 2023-12-01 Epub Date: 2023-09-09 DOI:10.1007/s11914-023-00820-8

Moritz Pappert, Sundeep Khosla, Madison Doolittle

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Abstract

Purpose of review: The purpose of this review is to discuss the role of macrophages in the regulation of skeletal health with age, particularly in regard to both established and unexplored mechanisms in driving inflammation and senescence.

Recent findings: A multitude of research has uncovered mechanisms of intrinsic aging in macrophages, detrimental factors released by these immune cells, and crosstalk from senescent mesenchymal cell types, which altogether drive age-related bone loss. Furthermore, bone marrow macrophages were recently proposed to be responsible for the megakaryocytic shift during aging and overall maintenance of the hematopoietic niche. Studies on extra-skeletal macrophages have shed light on possible conserved mechanisms within bone and highlight the importance of these cells in systemic aging. Macrophages are a critically important cell type in maintaining skeletal homeostasis with age. New discoveries in this area are of utmost importance in fully understanding the pathogenesis of osteoporosis in aged individuals.

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老年骨髓巨噬细胞对骨骼健康和衰老的影响

综述的目的：本综述旨在讨论巨噬细胞在随着年龄增长调节骨骼健康方面的作用，特别是在驱动炎症和衰老方面的既有机制和未探索机制：大量研究发现了巨噬细胞的内在衰老机制、这些免疫细胞释放的有害因子以及衰老间充质细胞类型的串扰，这些因素共同推动了与年龄相关的骨质流失。此外，最近有人提出，骨髓巨噬细胞在衰老过程中负责巨核细胞的转移和造血龛的整体维护。对骨骼外巨噬细胞的研究揭示了骨骼内可能存在的保守机制，并强调了这些细胞在全身衰老中的重要性。巨噬细胞是随着年龄增长而维持骨骼平衡的一种极其重要的细胞类型。该领域的新发现对于全面了解老年人骨质疏松症的发病机制至关重要。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.