Impacts and potential mechanisms of fine particulate matter (PM2.5) on male testosterone biosynthesis disruption.

IF 3 4区 医学 Q2 ENVIRONMENTAL SCIENCES Reviews on Environmental Health Pub Date : 2023-09-01 DOI:10.1515/reveh-2023-0064
Shaokai Zheng, Nannan Zhao, Xiaojun Lin, Lianglin Qiu
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Abstract

Exposure to PM2.5 is the most significant air pollutant for health risk. The testosterone level in male is vulnerable to environmental toxicants. In the past, researchers focused more attention on the impacts of PM2.5 on respiratory system, cardiovascular system, and nervous system, and few researchers focused attention on the reproductive system. Recent studies have reported that PM2.5 involved in male testosterone biosynthesis disruption, which is closely associated with male reproductive health. However, the underlying mechanisms by which PM2.5 causes testosterone biosynthesis disruption are still not clear. To better understand its potential mechanisms, we based on the existing scientific publications to critically and comprehensively reviewed the role and potential mechanisms of PM2.5 that are participated in testosterone biosynthesis in male. In this review, we summarized the potential mechanisms of PM2.5 triggering the change of testosterone level in male, which involve in oxidative stress, inflammatory response, ferroptosis, pyroptosis, autophagy and mitophagy, microRNAs (miRNAs), endoplasmic reticulum (ER) stress, and N6-methyladenosine (m6A) modification. It will provide new suggestions and ideas for prevention and treatment of testosterone biosynthesis disruption caused by PM2.5 for future research.

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细颗粒物(PM2.5)对男性睾酮生物合成干扰的影响及其潜在机制
PM2.5是对健康危害最大的空气污染物。男性体内的睾酮水平易受环境毒物的影响。过去研究人员更多关注PM2.5对呼吸系统、心血管系统和神经系统的影响,很少有研究人员关注生殖系统。近年来有研究报道,PM2.5与男性睾酮生物合成干扰有关,与男性生殖健康密切相关。然而,PM2.5导致睾酮生物合成中断的潜在机制尚不清楚。为了更好地了解其潜在机制,我们在现有科学出版物的基础上,对PM2.5参与男性睾酮生物合成的作用和潜在机制进行了批判性和全面的回顾。本文综述了PM2.5引发男性睾酮水平变化的潜在机制,包括氧化应激、炎症反应、铁亡、焦亡、自噬和有丝自噬、microrna (miRNAs)、内质网(ER)应激和n6 -甲基腺苷(m6A)修饰。为今后的研究提供预防和治疗PM2.5引起的睾酮生物合成中断的新建议和思路。
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来源期刊
Reviews on Environmental Health
Reviews on Environmental Health Social Sciences-Health (social science)
CiteScore
7.20
自引率
2.60%
发文量
75
期刊介绍: Reviews on Environmental Health (REVEH) is an international peer-reviewed journal that aims to fill the need for publication of review articles on hot topics in the field of environmental health. Reviews on Environmental Health aims to be an inspiring forum for scientists, environmentalists, physicians, engineers, and students who are concerned with aspects of human health, including quality of life, that are determined by physiological and psychosociological interactions between man and physical, chemical, biological, and social factors in the environment. Reviews on Environmental Health is an important niche served by no other journal, that’s being a site where thoughtful reviews can be published on a variety of subjects related to both health and environment. One challenge is to bridge the research on environmental causes of disease with the clinical practice of medicine. Reviews on Environmental Health is a source of integrated information on environment and health subjects that will be of value to the broad scientific community, whether students, junior and senior professionals, or clinicians.
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