Rescuing the Golgi from heat damages by ATG8: restoration rather than clean-up.

Abstract

High temperature stress poses significant adverse effects on crop yield and quality. Yet the molecular mechanisms underlying heat stress tolerance in plants/crops, especially regarding the organellar remodeling and homeostasis, are largely unknown. In a recent study, Zhou et al. reported that autophagy-related 8 (ATG8), a famous regulator involved in autophagy, plays a new role in Golgi restoration upon heat stress. Golgi apparatus is vacuolated following short-term acute heat stress, and ATG8 is translocated to the dilated Golgi membrane and interacts with CLATHRIN LIGHT CHAIN 2 (CLC2) to facilitate Golgi restoration, which is dependent on the ATG conjugation system, but not of the upstream autophagic initiators. These exciting findings broaden the fundamental role of ATG8, and elucidate the organelle-level restoration mechanism of Golgi upon heat stress in plants.