The quest for effective immunotherapies against malignant peripheral nerve sheath tumors: Is there hope?

IF 5.3 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Molecular Therapy Oncolytics Pub Date : 2023-09-21 DOI:10.1016/j.omto.2023.07.008
Siddhi N Paudel, Brian Hutzen, Timothy P Cripe
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Abstract

Immune-based therapies represent a new paradigm in the treatment of multiple cancers, where they have helped achieve durable and safe clinical responses in a growing subset of patients. While a wealth of information is available concerning the use of these agents in treating the more common malignancies, little has been reported about the use of immunotherapies against malignant peripheral nerve sheath tumors (MPNSTs), a rare form of soft tissue sarcoma that arises from the myelin sheaths that protect peripheral nerves. Surgical resection has been the mainstay of therapy in MPNSTs, but the recurrence rate is as high as 65%, and chemotherapy is generally ineffective. The immune contexture of MPNSTs, replete with macrophages and a varying degree of T cell infiltration, presents multiple opportunities to design meaningful therapeutic interventions. While preliminary results with macrophage-targeting strategies and oncolytic viruses are promising, identifying the subset of patients that respond to immune-based strategies will be a milestone. As part of our effort to help advance the use of immunotherapy for MPNSTs, here we describe recent insights regarding the immune contexture of MPNSTs, discuss emerging immune-based strategies, and provide a brief overview of potential biomarkers of response.

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对恶性周围神经鞘肿瘤有效免疫疗法的探索:有希望吗?
免疫疗法代表了一种治疗多种癌症的新模式,它们已帮助越来越多的患者实现持久和安全的临床反应。虽然关于使用这些药物治疗更常见的恶性肿瘤的信息丰富,但关于使用免疫疗法治疗恶性周围神经鞘肿瘤(MPNSTs)的报道很少,MPNSTs是一种罕见的软组织肉瘤,起源于保护周围神经的髓鞘。手术切除是治疗MPNSTs的主要方法,但复发率高达65%,化疗通常无效。mpnst的免疫环境充满巨噬细胞和不同程度的T细胞浸润,为设计有意义的治疗干预提供了多种机会。虽然巨噬细胞靶向策略和溶瘤病毒的初步结果很有希望,但确定对基于免疫的策略有反应的患者亚群将是一个里程碑。作为我们努力推进MPNSTs免疫治疗的一部分,我们在这里描述了关于MPNSTs免疫环境的最新见解,讨论了新兴的基于免疫的策略,并简要概述了潜在的反应生物标志物。
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来源期刊
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics Medicine-Oncology
CiteScore
10.90
自引率
3.50%
发文量
152
审稿时长
6 weeks
期刊介绍: Molecular Therapy — Oncolytics is an international, online-only, open access journal focusing on the development and clinical testing of viral, cellular, and other biological therapies targeting cancer.
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