The effect of HIV on COVID-19 vaccine responses.

IF 4.5 3区医学 Q2 IMMUNOLOGY Current Opinion in HIV and AIDS Pub Date : 2023-05-01 DOI:10.1097/COH.0000000000000790

Itzchak Levy, Galia Rahav

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引用次数: 3

Abstract

Purpose of review: Persons living with HIV (PLWH) may have a moderately increased risk of morbidity and mortality from COVID-19 infection, especially if viral load is not controlled and if they are immunosuppressed. Vaccination against SARS-CoV-2 is the most effective measure to prevent morbidity and mortality. However, individuals with HIV/AIDS may have less protection after vaccination. The purpose of this review is to summarize some of the recent studies focused on examining the safety, immunogenicity and effectiveness of anti-SARS-CoV-2 vaccines.

Recent findings: The safety of all anti-SARS-CoV-2 vaccines among PLWH is not different from the safety of these vaccines among HIV-negative individuals and is acceptable. PLWH with viral suppression and immune reconstitution (CD4 + cell count > 350 cells/μl) may reach almost same immunogenicity such as people without HIV albeit antibody levels and neutralization may decline more rapidly than in people without HIV. PLWH with viremia or immunosuppressed, especially AIDS, have less immunogenicity.

Summary: Full vaccination against SARS-CoV-2 is a well tolerated and efficient way to prevent mortality and morbidity from COVID-19 among PLWH and AIDS patients. It is very important to follow recommended booster vaccination for a continuous and prompt immunogenicity.

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艾滋病毒对COVID-19疫苗反应的影响

综述目的:HIV感染者(PLWH)因COVID-19感染而发病和死亡的风险可能有中度增加，特别是在病毒载量不受控制和免疫抑制的情况下。针对SARS-CoV-2的疫苗接种是预防发病和死亡的最有效措施。然而，艾滋病毒/艾滋病患者接种疫苗后的保护作用可能会降低。本文综述了近年来有关抗sars - cov -2疫苗安全性、免疫原性和有效性的研究进展。最新发现:所有抗sars - cov -2疫苗在艾滋病病毒阴性个体中的安全性与在艾滋病病毒阴性个体中的安全性没有差异，是可以接受的。具有病毒抑制和免疫重建(CD4 +细胞计数> 350细胞/μl)的PLWH可以达到与未感染HIV的人几乎相同的免疫原性，尽管抗体水平和中和可能比未感染HIV的人下降得更快。病毒血症或免疫抑制的PLWH，特别是艾滋病，具有较低的免疫原性。总结:全面接种SARS-CoV-2疫苗是预防艾滋病患者和艾滋病患者COVID-19死亡率和发病率的一种耐受性良好且有效的方法。遵循推荐的加强疫苗接种以获得持续和迅速的免疫原性是非常重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

7.40

自引率

7.30%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.