Accelerating HIV vaccine development through meaningful engagement of local scientists and communities.

IF 4.5 3区 医学 Q2 IMMUNOLOGY Current Opinion in HIV and AIDS Pub Date : 2023-11-01 Epub Date: 2023-09-11 DOI:10.1097/COH.0000000000000815
Kundai Chinyenze, Eunice Nduati, Vincent Muturi-Kioi
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引用次数: 1

Abstract

Purpose of review: There is a need to conduct multiple experimental medicine trials in regions with significant burden of disease to ensure the global relevance of vaccines under development including the African context.

Recent findings: African scientists can support accelerated HIV vaccine development by leading EMVTs in the region in a complementary fashion to global efforts and augment evidence generated to optimize and advance relevant vaccines towards licensure. The ADVANCE program enables EMVTs, where local scientists lead trial implementation and immunogenicity endpoint analysis of promising vaccine approaches. Concerted efforts towards scientific collaboration, enhancing specific clinical and lab capacity, and improving ethical and regulatory systems to review EMVTs in Africa will be catalytic. Appropriate engagement of local communities and stakeholders will be equally important, and the field needs to refine existing research literacy approaches to effectively partner with communities around current complex scientific approaches. Review of inclusion of relevant populations in early research is also needed.

Summary: African scientists and communities can help accelerate HIV vaccine development through stronger global collaboration. Now is the time for bold investments to enable the conduct of innovative EMVTs in Africa where the eventual vaccines will have the greatest impact.

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通过当地科学家和社区的有意义参与,加速艾滋病毒疫苗的开发。
审查目的:有必要在疾病负担严重的地区进行多项实验性药物试验,以确保正在开发的疫苗在全球范围内的相关性,包括在非洲范围内。最近的发现:非洲科学家可以支持加快艾滋病毒疫苗的开发,以补充全球努力的方式领导该地区的EMVT,并增加为优化和推进相关疫苗获得许可而产生的证据。ADVANCE计划使EMVT成为可能,当地科学家领导有前景的疫苗方法的试验实施和免疫原性终点分析。在科学合作、提高特定的临床和实验室能力以及改进伦理和监管系统以审查非洲的EMVT方面的协同努力将起到催化作用。当地社区和利益相关者的适当参与同样重要,该领域需要完善现有的研究扫盲方法,以围绕当前复杂的科学方法与社区有效合作。还需要审查将相关人群纳入早期研究的情况。摘要:非洲科学家和社区可以通过加强全球合作,帮助加快艾滋病毒疫苗的开发。现在是进行大胆投资的时候了,以便能够在非洲进行创新的EMVT,在那里,最终的疫苗将产生最大的影响。
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来源期刊
Current Opinion in HIV and AIDS
Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES
CiteScore
7.40
自引率
7.30%
发文量
115
审稿时长
6-12 weeks
期刊介绍: Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.
期刊最新文献
Recent data on the role of antiretroviral therapy in weight gain and obesity in persons living with HIV. Anticipating HIV viral escape - resistance to active and passive immunization. Accelerating HIV vaccine development through meaningful engagement of local scientists and communities. Guiding HIV-1 vaccine development with preclinical nonhuman primate research. Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.
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