Vascular Expression of Prostate-specific Membrane Antigen (PSMA) in MiTF Family Translocation Renal Cell Carcinoma and Related Neoplasms.

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY Applied Immunohistochemistry & Molecular Morphology Pub Date : 2023-09-01 Epub Date: 2023-07-20 DOI:10.1097/PAI.0000000000001142
Ezra G Baraban, Yasser Ged, Nirmish Singla, Mohammad E Allaf, Michael A Gorin, Mark C Markowski, Steven P Rowe, Pedram Argani
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Abstract

Multiple studies have demonstrated prostate-specific membrane antigen (PSMA) expression in the neo-vasculature of non-prostate tumors including clear cell renal cell carcinoma (ccRCC). However, PSMA expression in rare renal tumors including MiTF family translocation renal cell carcinoma has not been previously characterized. We examined PSMA expression by immunohistochemistry in a series of MiTF family translocation renal cell carcinomas as well as in several genetically related tumors including alveolar soft part sarcoma and PEComas with TFE3 rearrangements. PSMA expression was also studied in several cases of ccRCC and papillary RCC. Overall, PSMA immunohistochemistry was performed in 61 samples from 58 patients. Vascular PSMA expression was seen with the highest frequency in ccRCC [88% (14/16)] (38% focal, 50% diffuse). Translocation RCC (tRCC) demonstrated the second highest frequency of PSMA expression [71% (22/28)] (57% focal, 14% diffuse), followed by alveolar soft part sarcoma [50% (4/8)] (38% focal, 12% diffuse). No PSMA expression was seen in PEComas with TFE3 rearrangement (0/3) or papillary RCC (0/6). PSMA expression was only present in tumor-associated neo-vasculature. A patient with oligometastatic tRCC underwent 68 Ga-PSMA-11 PET imaging which detected multiple putative metastatic lesions not detected on conventional computed tomography imaging performed 2 weeks prior, supporting the potential utility of PSMA imaging in tRCC. These findings have potential implications for the utility of PSMA guided diagnostic and therapeutic agents in both common and uncommon renal cell carcinoma subtypes as well as genetically related mesenchymal neoplasms.

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前列腺特异性膜抗原(PSMA)在MiTF家族易位肾细胞癌及相关肿瘤中的血管表达。
多项研究表明,前列腺特异性膜抗原(PSMA)在包括透明细胞肾细胞癌(ccRCC)在内的非前列腺肿瘤的新血管系统中表达。然而,PSMA在包括MiTF家族易位肾细胞癌在内的罕见肾肿瘤中的表达先前尚未得到表征。我们通过免疫组织化学检测了PSMA在一系列MiTF家族易位肾细胞癌以及几种遗传相关肿瘤中的表达,包括肺泡软部肉瘤和具有TFE3重排的PEComas。还研究了PSMA在几个ccRCC和乳头状RCC中的表达。总体而言,对58名患者的61份样本进行了PSMA免疫组织化学检查。血管PSMA表达在ccRCC中最高[88%(14/16)](38%为局灶性,50%为弥漫性)。移位性RCC(tRCC)的PSMA表达频率位居第二[71%(22/28)](57%为局灶性,14%为弥漫性),其次是肺泡软部肉瘤[50%(4/8)](38%为局灶,12%为弥漫性。在TFE3重排的PEComas(0/3)或乳头状RCC(0/6)中未发现PSMA表达。PSMA仅在肿瘤相关的新血管系统中表达。一名低转移性tRCC患者接受了68 Ga-PSMA-11 PET成像,该成像检测到了2周前常规计算机断层扫描成像未检测到的多个假定转移性病变,支持PSMA成像在tRCC中的潜在用途。这些发现对PSMA指导的诊断和治疗剂在常见和不常见肾细胞癌亚型以及遗传相关间充质肿瘤中的应用具有潜在意义。
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来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
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