Phytopharmaceuticals and Herbal Approaches to Target Neurodegenerative Disorders.

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2023-09-01 DOI:10.1055/a-2076-7939
Anas Islam, Anuradha Mishra, Rabia Ahsan, Syed Fareha
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Abstract

Neurodegeneration is characterized as the continuous functional and structural loss of neurons, resulting in various clinical and pathological manifestations and loss of functional anatomy. Medicinal plants have been oppressed from ancient years and are highly considered throughout the world as a rich source of therapeutic means for the prevention, treatment of various ailments. Plant-derived medicinal products are becoming popular in India and other nations. Further herbal therapies shows good impact on chronic long term illnesses including degenerative conditions of neurons and brain. The use of herbal medicines continues to expand rapidly across the world. The active phytochemical constituents of individual plants are sometimes insufficient to achieve the desirable therapeutic effects. Combining the multiple herbs in a particular ratio (polyherbalism) will give a better therapeutic effect and reduce toxicity. Herbal-based nanosystems are also being studied as a way to enhance the delivery and bioavailability of phytochemical compounds for the treatment of neurodegenerative diseases. This review mainly focuses on the importance of the herbal medicines, polyherbalism and herbal-based nanosystems and its clinical significance for neurodegenerative diseases.

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靶向神经退行性疾病的植物药物和草药方法。
神经退行性变的特征是神经元的功能和结构的持续丧失,导致各种临床病理表现和功能解剖的丧失。药用植物自古以来就受到压迫,在世界各地被高度认为是预防和治疗各种疾病的治疗手段的丰富来源。植物衍生药物在印度和其他国家越来越受欢迎。进一步的草药疗法显示出对慢性长期疾病的良好影响,包括神经元和大脑的退行性疾病。草药的使用在世界范围内继续迅速扩大。单个植物的活性化学成分有时不足以达到理想的治疗效果。将多种草药按一定比例混合使用(多药制),可以达到更好的治疗效果,降低毒性。基于草药的纳米系统也正在被研究,作为一种提高植物化学化合物的递送和生物利用度的方法,用于治疗神经退行性疾病。本文主要综述了草药、多草药和基于草药的纳米系统在神经退行性疾病中的重要性及其临床意义。
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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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