Histopathological characteristics and HPV status in cervical biopsy specimens diagnosed as flat condyloma.

IF 1.3 Q4 MICROBIOLOGY Iranian Journal of Microbiology Pub Date : 2023-06-01 DOI:10.18502/ijm.v15i3.12909

Fatemeh Nategh, Mitra Mohit, Minoo Saatian, Zohreh Farahmand, Hoorieh Soleimanjahi

{"title":"Histopathological characteristics and HPV status in cervical biopsy specimens diagnosed as flat condyloma.","authors":"Fatemeh Nategh, Mitra Mohit, Minoo Saatian, Zohreh Farahmand, Hoorieh Soleimanjahi","doi":"10.18502/ijm.v15i3.12909","DOIUrl":null,"url":null,"abstract":"Background and objectives: HPV infections cause a wide spectrum of pathological changes in lower anogenital epithelium. The aim of this study was to investigate the HPV DNA status and histological findings in cervical biopsy specimens diagnosed as flat condyloma.Materials and methods: This study included 20 cervical biopsy specimens diagnosed as flat condyloma. The histopathological criteria and presence of HPV DNA were evaluated. HPV genotyping was determined in HPV-positive specimens using BioEdit software and the results were analyzed in SPSS software.Results: HPV DNA was not found in 30% of specimens and relative frequency of HPV genotypes was: 15% HPV6, 15% HPV11, 5% HPV16, 5% HPV18, 5% HPV53, 5% HPV68, 5% HPV84, 10% HPV45. Relative frequency of histopathological criteria was as below: 100% of specimens had koilocytosis, 100% acanthosis, 15% nuclear immaturity, 100% atypia, 15% mitotic activity, 50% dyskeratosis, 35% parakeratosis and 10% hyperkeratosis.Conclusion: There were significant differences between HPV positivity and two pathologic criteria; multinucleation and hyperkeratosis (P Value: 0.02). Nuclear immaturity was significantly more prevalent in high risk HPV-positive specimens (P Value: 0.03).","PeriodicalId":14633,"journal":{"name":"Iranian Journal of Microbiology","volume":"15 3","pages":"468-474"},"PeriodicalIF":1.3000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/46/96/IJM-15-468.PMC10336288.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijm.v15i3.12909","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 1

Abstract

Background and objectives: HPV infections cause a wide spectrum of pathological changes in lower anogenital epithelium. The aim of this study was to investigate the HPV DNA status and histological findings in cervical biopsy specimens diagnosed as flat condyloma.

Materials and methods: This study included 20 cervical biopsy specimens diagnosed as flat condyloma. The histopathological criteria and presence of HPV DNA were evaluated. HPV genotyping was determined in HPV-positive specimens using BioEdit software and the results were analyzed in SPSS software.

Results: HPV DNA was not found in 30% of specimens and relative frequency of HPV genotypes was: 15% HPV6, 15% HPV11, 5% HPV16, 5% HPV18, 5% HPV53, 5% HPV68, 5% HPV84, 10% HPV45. Relative frequency of histopathological criteria was as below: 100% of specimens had koilocytosis, 100% acanthosis, 15% nuclear immaturity, 100% atypia, 15% mitotic activity, 50% dyskeratosis, 35% parakeratosis and 10% hyperkeratosis.

Conclusion: There were significant differences between HPV positivity and two pathologic criteria; multinucleation and hyperkeratosis (P Value: 0.02). Nuclear immaturity was significantly more prevalent in high risk HPV-positive specimens (P Value: 0.03).

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

诊断为扁平尖锐湿疣的宫颈活检标本的组织病理学特征和HPV状态。

背景和目的:HPV感染引起下肛门生殖上皮广泛的病理改变。本研究的目的是探讨宫颈活检标本诊断为扁平尖锐湿疣的HPV DNA状态和组织学结果。材料和方法:本研究纳入诊断为扁平尖锐湿疣的20例宫颈活检标本。评估组织病理学标准和HPV DNA的存在。采用BioEdit软件对HPV阳性标本进行HPV基因分型，并用SPSS软件对结果进行分析。结果:30%的标本未检出HPV DNA, HPV基因型的相对频率分别为:HPV6、HPV11、HPV16、HPV18、HPV53、HPV68、HPV84、HPV45。组织病理标准的相对频率如下:100%的标本有空细胞增生，100%棘层增生，15%的标本核不成熟，100%的标本异型，15%的标本有丝分裂活性，50%的标本角化不良，35%的标本角化不全，10%的标本角化过度。结论:HPV阳性与两项病理标准有显著性差异;多核、角化过度(P值:0.02)。核不成熟在高危hpv阳性标本中更为普遍(P值:0.03)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Iranian Journal of Microbiology MICROBIOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.