New insights into the role of thrombospondin-1 in glioblastoma development

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-09-09 DOI:10.1016/j.semcdb.2023.09.001
Andreas Bikfalvi , Joris Guyon , Thomas Daubon
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引用次数: 1

Abstract

Glioblastoma (GB), the most malignant subtype of diffuse glioma, is highly aggressive, invasive and vascularized. Its median survival is still short even with maximum standard care. There is a need to identify potential new molecules and mechanisms, that are involved in the interactions of GB cells with the tumor microenvironment (TME), for therapeutic intervention. Thrombospondin-1 (TSP1) is a multi-faceted matricellular protein which plays a significant role in development, physiology and pathology including cancer. Recent studies have pinpoint an important role of TSP1 in GB development which will be summarized and discussed herein. We will discuss studies, mainly from preclinical research, which should lead to a deeper understanding of TSP1’s role in GB development. We will also discuss some issues with regard to the use of this knowledge for the clinic.

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血小板反应蛋白-1在胶质母细胞瘤发展中的作用的新见解。
胶质母细胞瘤(GB)是弥漫性胶质瘤中最恶性的亚型,具有高度侵袭性、侵袭性和血管化。即使有最高标准的护理,其中位生存期仍然很短。需要确定参与GB细胞与肿瘤微环境(TME)相互作用的潜在新分子和机制,以进行治疗干预。血小板反应蛋白-1(TSP1)是一种多方面的基质细胞蛋白,在包括癌症在内的发育、生理和病理过程中起着重要作用。最近的研究已经确定了TSP1在GB发展中的重要作用,本文将对此进行总结和讨论。我们将讨论主要来自临床前研究的研究,这将有助于更深入地了解TSP1在GB发展中的作用。我们还将讨论一些关于将这些知识用于临床的问题。
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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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