Seminars in cell & developmental biology最新文献

英文中文

Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms 后生动物上皮细胞的可塑性：角色和机制的进化见解。

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2026-05-01 Epub Date: 2026-03-03 DOI: 10.1016/j.semcdb.2026.103670

Hiroki Nagai , Yu-ichiro Nakajima

Epithelial tissues function as multicellular communities that preserve tissue integrity while adapting to diverse environmental stresses by altering cell behaviors. A striking manifestation of such adaptability is cell plasticity, the ability of differentiated cells to revert to stem-like states or adopt alternative fates. Once considered rare and confined to highly regenerative species, cell plasticity is now recognized across the metazoan tree. In early-branching animals such as sponges and cnidarians, transdifferentiation and dedifferentiation are integral to life-cycle transitions and regeneration, whereas in more complex organisms, these processes typically emerge under stress, including stem cell loss or environmental perturbations. Here, we examine epithelial cell plasticity through evolutionary, cellular, and molecular perspectives. Focusing on the intestinal epithelium, we explore findings from mammalian and Drosophila models showing that progenitors and even terminally differentiated cells can dedifferentiate in response to external stimuli that disrupt homeostasis, such as pathogen infection and nutrient fluctuations. We further discuss conserved mechanisms involving intercellular signaling (e.g., Notch, EGFR, and JAK-STAT) and chromatin states primed for reprogramming, modulated by metabolic cues. Together, these insights position cell plasticity as an ancient environmental adaptation strategy, shaped by conserved molecular toolkits and refined by species- and cell lineage-specific innovations.

上皮组织作为多细胞群落，通过改变细胞行为来适应不同的环境压力，同时保持组织的完整性。这种适应性的一个显著表现是细胞可塑性，即分化细胞恢复到茎样状态或接受不同命运的能力。细胞可塑性曾经被认为是罕见的，并且局限于高度再生的物种，现在在整个后生动物树中被认识到。在海绵和刺胞动物等早期分支动物中，转分化和去分化是生命周期转变和再生的组成部分，而在更复杂的生物中，这些过程通常在压力下发生，包括干细胞丢失或环境扰动。在这里，我们从进化、细胞和分子的角度来研究上皮细胞的可塑性。以肠上皮为重点，我们探讨了哺乳动物和果蝇模型的研究结果，表明祖细胞甚至终末分化细胞在外部刺激破坏体内平衡（如病原体感染和营养波动）时可以去分化。我们进一步讨论了涉及细胞间信号传导（如Notch、EGFR和JAK-STAT）和染色质状态的保守机制，这些机制由代谢信号调节，为重编程启动。总之，这些见解将细胞可塑性定位为一种古老的环境适应策略，由保守的分子工具包塑造，并由物种和细胞谱系特异性创新完善。

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引用次数: 0

Intra- and inter-organ communications in aging and cancer: Local and global spatial perspectives 衰老和癌症中的器官间和内部通讯：局部和全局空间视角。

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2026-05-01 Epub Date: 2026-03-05 DOI: 10.1016/j.semcdb.2026.103672

Onkar Mulay , Aitor Benedicto , Yui Murata , Monica Suet Ying Ng , Jazmina L. Gonzalez Cruz , Quan Nguyen

Interactions among neighbouring cells are fundamental to tissue function and can be specifically mapped using single-cell and spatial transcriptomics data. Overall, cell-cell interactions (CCIs) are essential for proper tissue function, including cell development, maintenance of tissue homeostasis, and immune responses during disease. Cells also communicate between organs by releasing signalling molecules into the circulatory system. We examined aging and cancer progression, the two important biological processes where alterations in CCIs remodel the tissue microenvironments that drive cellular and tissue dysfunction. Identifying these dysregulated interactions can uncover potential therapeutic strategies to prevent or treat disease by targeting specific ligand-receptor interactions. Interestingly, in aging and cancer metastasis, ligands originating from one organ can influence the aging processes of distant organs, while local interactions within the tumour microenvironment are critical for not only cancer dynamics at the primary site but also for driving its progression to secondary organs. This review highlights key ligand-receptor interactions in aging and cancer metastasis and examines intra- and inter-organ communication inference tools in this emerging field.

邻近细胞之间的相互作用是组织功能的基础，可以使用单细胞和空间转录组学数据特异性地绘制。总的来说，细胞-细胞相互作用（CCIs）对正常的组织功能至关重要，包括细胞发育、组织稳态的维持和疾病期间的免疫反应。细胞还通过向循环系统释放信号分子来实现器官间的交流。我们研究了衰老和癌症进展这两个重要的生物学过程，其中CCIs的改变重塑了驱动细胞和组织功能障碍的组织微环境。识别这些失调的相互作用可以揭示潜在的治疗策略，通过靶向特定的配体-受体相互作用来预防或治疗疾病。有趣的是，在衰老和癌症转移中，源自一个器官的配体可以影响远端器官的衰老过程，而肿瘤微环境中的局部相互作用不仅对原发部位的癌症动态至关重要，而且对推动其向继发器官的进展也至关重要。本文综述了衰老和癌症转移中关键的配体-受体相互作用，并研究了这一新兴领域的器官内和器官间通讯推断工具。

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引用次数: 0

Morphogenetic evolution with physical influences 受物理影响的形态发生进化

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2026-05-01 Epub Date: 2026-03-09 DOI: 10.1016/j.semcdb.2026.103671

Tzu-Yi Huang , Steffen Lemke , Yu-Chiun Wang

Morphogenesis is the process in which cells, tissues, organs and embryos acquire orderedness, patterns, shapes and higher order organizations. Most morphogenetic processes are known to be controlled by genetic programs, and experimental and theoretical studies have indeed provided strong support that evolutionary changes of morphogenetic mechanisms can largely be attributed to genetic modifications. Studies in the last decades had begun to reveal the contribution of physical mechanisms in a growing number of morphogenetic contexts, wherein they act in parallel with, and at times independent of, genes, leading to stochastic and self-organized behaviors. The involvement of physical mechanisms raises intriguing questions as to how they might influence the evolutionary dynamics of morphogenesis, and whether there might be themes and patterns that have not been previously conceptualized. In this review, we examine an ensemble of physical factors and mechanical processes shown recently in empirical and theoretical studies to be critical contributors of morphogenetic mechanisms. We ask whether some of these might have arisen prior to, and possibly shaped, the emergence of genetic programs. We consider conceptual frameworks that could support these hypothetical scenarios, and further propose a ‘leap-and-patch’ model, whereby morphogenetic systems exhibit a phase transition-like shift to a distinct phenotypic regime in response to changes in physical parameters (‘leaps’), thereby facilitating genetic accommodation or evolutionary innovation of novel morphogenetic mechanisms (‘patches’). Our discussion suggests the possibility that physical factors might be more than a contributor of morphogenesis, but a facilitator of evolutionary transition or innovation.

形态发生是细胞、组织、器官和胚胎获得有序、模式、形状和高级组织的过程。大多数形态发生过程是由遗传程序控制的，实验和理论研究确实为形态发生机制的进化变化在很大程度上归因于遗传修饰提供了强有力的支持。过去几十年的研究已经开始揭示物理机制在越来越多的形态发生背景下的贡献，其中它们与基因并行，有时独立于基因，导致随机和自组织行为。物理机制的参与提出了一些有趣的问题，如它们如何影响形态发生的进化动力学，以及是否可能存在以前未被概念化的主题和模式。在这篇综述中，我们研究了最近在实证和理论研究中显示的物理因素和机械过程的集合，这些因素和机械过程是形态发生机制的关键贡献者。我们想知道，其中的一些是否可能在基因程序出现之前就已经出现了，并可能形成了遗传程序的出现。我们考虑了可以支持这些假设情景的概念框架，并进一步提出了一个“跳跃-补丁”模型，即形态发生系统在响应物理参数的变化（“飞跃”）时表现出向不同表型的相变样转变，从而促进了新的形态发生机制（“补丁”）的遗传调节或进化创新。我们的讨论表明，物理因素可能不仅仅是形态发生的贡献者，而是进化过渡或创新的促进者。

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引用次数: 0

Biology computes: Information processing across biological scales. 生物学计算：跨生物尺度的信息处理。

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2026-03-20 DOI: 10.1016/j.semcdb.2026.103673

Alex J H Fedorec, Harry-Luke O McClelland

引用次数: 0

Machines all the way up and cognition all the way down: Updating the machine metaphor in biology 机器一路向上，认知一路向下：更新生物学中的机器隐喻。

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1016/j.semcdb.2026.103668

Michael Levin , Richard Watson

Cell and developmental biology (CDB) offer numerous remarkable examples of collective adaptive plasticity, as cells coordinate to implement large-scale form and function. Despite the gaps in understanding, it is often assumed that the machine metaphor (dominating molecular and cell biology) will explain all of the adaptive complexity involved, from molecules up. In the case of goal-driven intentional agents, however, living tissues have cognitive properties that seem different from machines. So what is the relationship between cognition and CDB, and can the machine metaphor accommodate it? The relationship between ‘ordinary’ machine-like matter and minded agents is often treated naively, as if: a) a complexity threshold exists above which memory, learning, problem solving and intelligence are possible, but below which there is no such thing, b) this putative threshold lies far outside the remit of day-to-day CDB, and c) the identification of mechanisms (e.g. cell signalling, morphogens and pathways) confirms the absence of cognition, as if mechanism and ‘real cognition’ were mutually exclusive. In this paper, we argue that, in fact, CDB is the only discipline that can possibly naturalise the cognition of biological matter avoiding such exceptionalist and dualist positions, and that doing so requires a multiscale approach that also offers interdisciplinary insight in the other direction. Specifically, characterizing a continuum of cognitive competencies (without a naïve threshold) and identifying its mechanisms (without explaining it away) illuminates the gaps in our understanding of CDB’s extraordinary collective adaptive plasticity.

细胞和发育生物学（CDB）提供了许多集体适应可塑性的显著例子，因为细胞协调实现大规模的形式和功能。尽管在理解上存在差距，但人们通常认为机器隐喻（主导分子和细胞生物学）将解释所有涉及的适应性复杂性，从分子开始。然而，在目标驱动的有意代理的情况下，活体组织具有与机器不同的认知特性。那么认知和CDB之间的关系是什么，机器隐喻能适应这种关系吗？“普通的”类似机器的物质和有意识的代理人之间的关系常常被天真地对待，好像：a)存在一个复杂性阈值，超过这个阈值，记忆、学习、解决问题和智力就有可能存在，但低于这个阈值，就没有这样的东西了；b)这个假定的阈值远远超出了日常CDB的范围；c)对机制（例如细胞信号传导、形态因子和途径）的识别证实了认知的缺失，就好像机制和“真正的认知”是相互排斥的。在本文中，我们认为，事实上，CDB是唯一可能将生物物质的认知自然化的学科，避免了这种例外论和二元论的立场，这样做需要一种多尺度的方法，也提供了另一个方向的跨学科洞察力。具体来说，描述认知能力的连续体（没有naïve阈值）和确定其机制（没有解释它）阐明了我们对CDB非凡的集体适应可塑性的理解中的差距。

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引用次数: 0

A cellular and molecular perspective on organotypic lymphatic (dys)function 器官型淋巴（天）功能的细胞和分子观点

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.semcdb.2025.103665

Sanjay Sunil Kumar , Katharina Uphoff , Sophie Hötte , Verena Prokosch , Stefan Schulte-Merker , Dörte Schulte-Ostermann

The lymphatic vascular system maintains fluid homeostasis, allows uptake of dietary lipids, and serves as a conduit for immune cell trafficking. Functional aspects of the lymphatic vasculature are governed by specific features of lymphatic endothelial cells that line these vessels. Dysfunction of lymphatic endothelial cells can result in various consequences at the organ and at the systemic level including lymphedema formation. In this review, we explore the underlying molecular mechanisms and signaling cascades that drive lymphatic development and vessel formation. We discuss human genetic disorders that lead to primary lymphedema and corresponding in vivo disease models that have helped to expand our molecular understanding pertaining to the signaling cascades governing lymphatic vessel development and maturation, in particular the VEGFC/VEGFR3 and ANG/TIE signaling axes. Furthermore, we highlight recent advancements regarding the anatomy and function of meningeal lymphatics and the Schlemm's canal in the context of development and disease.

淋巴血管系统维持体液平衡，允许摄取膳食脂质，并作为免疫细胞运输的管道。淋巴血管的功能方面是由排列在这些血管上的淋巴内皮细胞的特定特征决定的。淋巴内皮细胞的功能障碍可导致器官和全身水平的各种后果，包括淋巴水肿的形成。在这篇综述中，我们探讨了驱动淋巴发育和血管形成的潜在分子机制和信号级联。我们讨论了导致原发性淋巴水肿的人类遗传疾病和相应的体内疾病模型，这些模型有助于扩大我们对控制淋巴管发育和成熟的信号级联的分子理解，特别是VEGFC/VEGFR3和ANG/TIE信号轴。此外，我们强调在发育和疾病的背景下，关于脑膜淋巴管和施莱姆管的解剖和功能的最新进展。

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引用次数: 0

Editorial for special issue: Environmental control of oogenesis and ovulatory dynamics 特刊社论：卵子发生和排卵动力学的环境控制。

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-11-01 Epub Date: 2025-10-08 DOI: 10.1016/j.semcdb.2025.103659

Chii Jou Chan

引用次数: 0

The interplay of tissue mechanics and gene regulatory networks in the evolution of morphogenesis 组织力学和基因调控网络在形态发生进化中的相互作用

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-11-01 Epub Date: 2025-09-26 DOI: 10.1016/j.semcdb.2025.103654

James DiFrisco, Rashmi Priya

Recent years have seen the growth of work illuminating the mechanical aspects of morphogenesis, but its relationship to the established ideas and evidence of developmental and evolutionary genetics remains enigmatic. This review aims to re-assess the conceptual relationship between mechanics and genetics in the context of animal morphogenesis. We propose a view in which genetic programs—understood as gene regulatory networks—and processes of physical self-organization are not conflicting models of development, but instead play necessary and complementary causal roles at cellular and supra-cellular length scales, respectively. Current evidence from evolutionary genetics supports the hypothesis that this form of complementarity may be necessary for morphogenesis to be evolvable.

近年来，关于形态发生的机械方面的研究越来越多，但它与发育和进化遗传学的既定观点和证据的关系仍然是一个谜。这篇综述旨在重新评估在动物形态发生的背景下力学和遗传学之间的概念关系。我们提出了一种观点，认为遗传程序（被理解为基因调控网络）和物理自组织过程并不是相互冲突的发展模式，而是在细胞和超细胞长度尺度上分别发挥必要和互补的因果作用。目前来自进化遗传学的证据支持这样的假设，即这种形式的互补可能是形态发生进化所必需的。

引用次数: 0

Mechanical mechanisms of morphogenesis as potential substrates for evolutionary change 形态发生的机械机制作为进化变化的潜在底物

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-11-01 Epub Date: 2025-08-23 DOI: 10.1016/j.semcdb.2025.103645

Suhrid Ghosh , Chandrashekar Kuyyamudi , Beatrice L. Steinert , Cassandra G. Extavour

The first quarter of this century has seen a resurgence of interest in the mechanical and physical mechanisms that drive cellular behaviors in the context of morphogenesis. Far from being a new discovery, the fact that the material properties of cells and the physical forces that they exert and experience must play decisive roles in development, was an important part of the field of experimental embryology well over a century ago. Following the birth of molecular biology, and the development of live imaging approaches that can capture the dynamics of both cellular properties and materials, and the activity of genes and gene products, the current manifestation of this field promises to link mechanical and molecular genetic mechanisms. Here we review recent advances in understanding the relationships between mechanical and molecular genetic mechanisms, and suggest paths forward that could yield answers to the pressing questions of whether and how evolutionary forces act not only on functional morphologies, but also on the mechanical forces that create them.

本世纪头25年，在形态发生的背景下，对驱动细胞行为的机械和物理机制的兴趣重新抬头。细胞的物质特性以及它们所施加和经历的物理力在发育过程中一定起着决定性的作用，这一事实远非一个新发现，早在一个多世纪以前，它就是实验胚胎学领域的一个重要组成部分。随着分子生物学的诞生，以及实时成像方法的发展，可以捕捉细胞特性和材料的动态，以及基因和基因产物的活性，该领域目前的表现有望将机械和分子遗传机制联系起来。在这里，我们回顾了在理解机械和分子遗传机制之间的关系方面的最新进展，并提出了可以回答进化力是否以及如何不仅作用于功能形态，而且作用于创造它们的机械力这一紧迫问题的前进道路。

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引用次数: 0

How growth-induced stresses guide shape changes during animal morphogenesis: Mechanisms and implications 生长诱导的应激如何在动物形态发生过程中引导形状变化：机制和意义。

IF 6 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology

Pub Date : 2025-11-01 Epub Date: 2025-10-16 DOI: 10.1016/j.semcdb.2025.103661

A. Erlich , S. Harmansa

Morphogenesis, the process by which an organism develops its shape, is orchestrated by a complex interplay of genetic, biochemical, and mechanical factors. While myosin-driven contractility has been widely acknowledged as a critical driver of tissue shaping, emerging evidence suggests that differential growth (i.e. variations in growth rates within or between tissues) plays an equally vital role. Differential growth generates mechanical stresses that drive deformations at both cellular and tissue scales, shaping functional organ morphologies. This review introduces the core principles of growth mechanics in animal tissues and demonstrates how differential growth contributes to the generation of mechanical stresses that shape organs through processes such as folding, bending, and buckling, especially when different tissue layers or extracellular matrices impose external constraints. Furthermore, because cells can sense and respond to stresses, we highlight how integrating theoretical modelling with experimental data deepens our understanding of the feedback loops by which growth-induced stresses arise and mechanically guide functional shapes. Our aim is to engage developmental biologists by highlighting well-established insights from solid mechanics and plant biology on differential growth as a means to generate stress and shape tissue, complementing and extending the traditional focus on contractility.

形态发生是生物体形成其形状的过程，是由遗传、生化和机械因素复杂的相互作用精心安排的。虽然肌球蛋白驱动的收缩力已被广泛认为是组织形成的关键驱动因素，但新出现的证据表明，差异生长（即组织内或组织间生长速率的变化）也起着同样重要的作用。差异生长产生机械应力，驱动细胞和组织尺度的变形，形成功能器官形态。这篇综述介绍了动物组织生长力学的核心原理，并展示了不同的生长如何通过折叠、弯曲和屈曲等过程产生机械应力，特别是当不同的组织层或细胞外基质施加外部约束时。此外，由于细胞可以感知和响应压力，我们强调如何将理论建模与实验数据相结合，加深我们对生长诱导的压力产生和机械引导功能形状的反馈回路的理解。我们的目标是通过强调固体力学和植物生物学关于差异生长的成熟见解来吸引发育生物学家，作为产生压力和塑造组织的手段，补充和扩展传统对收缩性的关注。

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