Topographical Distribution of Neuroanatomical Abnormalities Following COVID-19 Invasion : A Systematic Literature Review.

IF 2.8 3区 医学 Q2 Medicine Clinical Neuroradiology Pub Date : 2024-03-01 Epub Date: 2023-09-11 DOI:10.1007/s00062-023-01344-5
Ceyda Kiyak, Ogochukwu Ann Ijezie, Joseph A Ackah, Matthew Armstrong, Jake Cowen, Deniz Cetinkaya, Hana Burianová, Theophilus N Akudjedu
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Abstract

Purpose: This systematic review is aimed at synthesising the literature base to date on the frequency and topographical distribution of neuroanatomical changes seen on imaging following COVID-19 invasion with a focus on both the acute and chronic phases of the disease.

Methods: In this study, 8 databases were systematically searched to identify relevant articles published from December 2019 to March 2022 and supplemented with a manual reference search. Data were extracted from the included studies and narrative synthesis was employed to integrate the findings.

Results: A total of 110 studies met the inclusion criteria and comprised 119,307 participants (including 31,073 acute and 143 long COVID-19 patients manifesting neurological alterations) and controls. Considerable variability in both the localisation and nature of neuroanatomical abnormalities are noted along the continuum with a wide range of neuropathologies relating to the cerebrovascular/neurovascular system, (sub)cortical structures (including deep grey and white matter structures), brainstem, and predominant regional and/or global alterations in the cerebellum with varying degrees of spinal involvement.

Conclusion: Structural regional alterations on neuroimaging are frequently demonstrated in both the acute and chronic phases of SARS-CoV‑2 infection, particularly prevalent across subcortical, prefrontal/frontal and cortico-limbic brain areas as well as the cerebrovascular/neurovascular system. These findings contribute to our understanding of the acute and chronic effects of the virus on the nervous system and has the potential to provide information on acute and long-term treatment and neurorehabilitation decisions.

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COVID-19 侵袭后神经解剖异常的地形分布:系统性文献综述。
目的:本系统性综述旨在综合迄今为止关于COVID-19侵袭后成像所见神经解剖变化的频率和地形分布的文献基础,重点关注疾病的急性期和慢性期:在本研究中,系统检索了8个数据库,以确定2019年12月至2022年3月期间发表的相关文章,并辅以人工参考文献检索。从纳入的研究中提取数据,并采用叙事综合法对研究结果进行整合:共有110项研究符合纳入标准,包括119,307名参与者(包括31,073名急性和143名长期COVID-19患者,表现为神经系统改变)和对照组。神经解剖学异常的定位和性质在连续性上存在很大差异,神经病理学的范围很广,涉及脑血管/神经血管系统、(亚)皮层结构(包括深灰质和白质结构)、脑干、小脑的主要区域和/或整体改变以及不同程度的脊柱受累:结论:在 SARS-CoV-2 感染的急性期和慢性期,神经影像学上的区域结构改变都很常见,尤其是皮层下、前额叶/额叶和皮质-边缘脑区以及脑血管/神经血管系统。这些发现有助于我们了解病毒对神经系统的急性和慢性影响,并有可能为急性和长期治疗及神经康复决策提供信息。
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来源期刊
Clinical Neuroradiology
Clinical Neuroradiology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.90
自引率
3.60%
发文量
0
期刊介绍: Clinical Neuroradiology provides current information, original contributions, and reviews in the field of neuroradiology. An interdisciplinary approach is accomplished by diagnostic and therapeutic contributions related to associated subjects. The international coverage and relevance of the journal is underlined by its being the official journal of the German, Swiss, and Austrian Societies of Neuroradiology.
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