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Long-term Safety and Efficacy of the Derivo Embolization Device in a Single-center Series. 单中心系列研究中 Derivo 栓塞设备的长期安全性和有效性。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-05-30 DOI: 10.1007/s00062-024-01423-1
Lukas Goertz, David Zopfs, Jonathan Kottlors, Jan Borggrefe, Lenhard Pennig, Marc Schlamann, Christoph Kabbasch

Purpose: This study analyzes the long-term clinical and angiographic outcomes of the Derivo Embolization Device (DED), an advanced flow diverter device with an electropolished surface, for the treatment of intracranial aneurysms.

Methods: A consecutive series of 101 patients (mean age: 58 years, 72% female) treated with the DED for 122 aneurysms at a single center between 2017 and 2023 was retrospectively analyzed for major (change in National Institutes of Health Stroke Scale [NIHSS] score ≥ 4 points) and minor (change in NIHSS score < 4 points) neurological events, procedural morbidity (increase of at least one point on the modified Rankin Scale), and angiographic results.

Results: There were 14 (11%) recurrent aneurysms, 15 (12%) ruptured aneurysms, 26 (21%) posterior circulation aneurysms and 16 (13%) fusiform or dissecting aneurysms. Device deployment failed in 1 case (1%). Procedure-related symptomatic procedural complications consisted of 2 (2%) major events (1 major stroke and 1 vessel perforation with intracranial hemorrhage and infarction) and 6 minor events (6 minor strokes). Procedural morbidity was 5%. There were no late ischemic or hemorrhagic events during follow-up. Complete and favorable aneurysm occlusion was achieved in 54% (40/74) and 62% (46/74) at a mean of 5 months, 71% (27/38) and 87% (33/38) at a mean of 12 months, and 76% (25/33) and 97% (32/33) at a mean of 35 months, respectively.

Conclusion: The results demonstrate progressive aneurysm occlusion beyond 12 months after DED implantation with an almost 100% favorable occlusion rate. Procedural morbidity was low and there were no late complications.

目的:本研究分析了Derivo栓塞装置(DED)治疗颅内动脉瘤的长期临床和血管造影结果:回顾性分析了2017年至2023年间在一个中心使用DED治疗122个动脉瘤的101名患者(平均年龄:58岁,72%为女性)的主要(美国国立卫生研究院卒中量表[NIHSS]评分≥4分的变化)和次要(NIHSS评分的变化)结果:复发性动脉瘤 14 例(11%),破裂动脉瘤 15 例(12%),后循环动脉瘤 26 例(21%),纺锤形或剥离动脉瘤 16 例(13%)。1例(1%)设备部署失败。与手术相关的症状性并发症包括 2 例(2%)重大并发症(1 例重大中风和 1 例血管穿孔伴颅内出血和梗死)和 6 例轻微并发症(6 例轻微中风)。手术发病率为 5%。随访期间没有发生后期缺血或出血事件。在平均 5 个月时,分别有 54% (40/74) 和 62% (46/74)、71% (27/38) 和 87% (33/38)、76% (25/33) 和 97% (32/33) 在平均 35 个月时实现了完全和良好的动脉瘤闭塞:结果表明,DED 植入术后 12 个月后动脉瘤逐渐闭塞,良好闭塞率几乎达到 100%。手术的发病率很低,而且没有后期并发症。
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引用次数: 0
Propensity Score-matched Comparison of WEB 17 and WEB 21 with 4-7 mm Device Sizes for the Treatment of Unruptured Intracranial Aneurysms. 用于治疗未破裂颅内动脉瘤的 WEB 17 和 WEB 21 与 4-7 毫米装置尺寸的倾向得分匹配比较。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-19 DOI: 10.1007/s00062-024-01430-2
Lukas Goertz, Thomas Liebig, Eberhard Siebert, David Zopfs, Lenhard Pennig, Marc Schlamann, Alexandra Radomi, Franziska Dorn, Christoph Kabbasch

Purpose: The WEB 17 system represents the fifth generation of Woven Endobridge (WEB) flow disruptors and features a low profile with fewer wires than its predecessor, the WEB 21. The present study compares the safety and efficacy of the WEB 17 and WEB 21 for the treatment of unruptured cerebral aneurysms with 4-7 mm device sizes, which were available for both systems.

Methods: Patient and aneurysm characteristics, complications, clinical outcome and angiographic results were retrospectively analysed. 1:1 propensity score matching was performed to adjust for minor baseline differences between the groups.

Results: Sixty aneurysms treated with WEB 21 and 90 with WEB 17 were included. The overall failure rate (deployment failure and adjunctive stent) was significantly higher with WEB 21 (16.7%) than with WEB 17 (3.3%, p < 0.01). The rates of neurological events between WEB 21 (6.7%) and WEB 17 treatment (1.1%) were not significantly different (p = 0.08). Also, procedural morbidity was comparably low in both groups (WEB 21: 3.3%, WEB 17: 0%, p = 0.16). The rates of complete/adequate occlusion at follow up were 69.7%/86.4% for WEB 17 vs. 80.4%/91.3% for WEB 21 at short-term (p = 0.27), and 64.5%/83.9% vs. 75.9%/86.2% at mid-term (p = 0.41), respectively. Propensity score matching confirmed the results of the unmatched series.

Conclusion: WEB 17 and WEB 21 had a similar safety and efficacy profile, but WEB 17 was associated with an improved feasibility. Prospective studies with long-term follow-up will define the full potential of the WEB 17 system.

目的:WEB 17系统代表了第五代编织内桥(WEB)血流阻断器,与其前身WEB 21相比,WEB 17具有外形低矮、导线较少的特点。本研究比较了 WEB 17 和 WEB 21 用于治疗未破裂脑动脉瘤的安全性和有效性,两种系统的装置尺寸均为 4-7 毫米:对患者和动脉瘤特征、并发症、临床结果和血管造影结果进行了回顾性分析。进行1:1倾向评分匹配,以调整两组间的微小基线差异:结果:60 例动脉瘤接受了 WEB 21 的治疗,90 例接受了 WEB 17 的治疗。使用 WEB 21 的总体失败率(部署失败和辅助支架)(16.7%)明显高于使用 WEB 17 的失败率(3.3%,P 结论:WEB 21 和 WEB 17 在动脉瘤治疗方面的差异很小:WEB 17 和 WEB 21 的安全性和疗效相似,但 WEB 17 的可行性更高。长期随访的前瞻性研究将确定 WEB 17 系统的全部潜力。
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引用次数: 0
Clinical Use of Hematoma Volume Based On Automated Segmentation of Chronic Subdural Hematoma Using 3D U-Net. 基于使用 3D U-Net 自动分割慢性硬膜下血肿的血肿体积临床应用。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-05-30 DOI: 10.1007/s00062-024-01428-w
Takayuki Inomata, Koji Nakaya, Mikio Matsuhiro, Jun Takei, Hiroto Shiozaki, Yasuto Noda

Purpose: To propose a method for calculating hematoma volume based on automatic segmentation of chronic subdural hematoma (CSDH) using 3D U‑net and investigate whether it can be used clinically to predict recurrence.

Methods: Hematoma volumes manually measured from pre- and postoperative computed tomography (CT) images were used as ground truth data to train 3D U‑net in 200 patients (400 CT scans). A total of 215 patients (430 CT scans) were used as test data to output segmentation results from the trained 3D U‑net model. The similarity with the ground truth data was evaluated using Dice scores for pre and postoperative separately. The recurrence prediction accuracy was evaluated by obtaining receiver operating characteristic (ROC) curves for the segmentation results. Using a typical mobile PC, the computation time per case was measured and the average time was calculated.

Results: The median Dice score of the test data were preoperative hematoma volume (Pre-HV): 0.764 and postoperative subdural cavity volume (Post-SCV): 0.741. In ROC analyses assessing recurrence prediction, the area under the curve (AUC) of the manual was 0.755 in Pre-HV, whereas the 3D U‑net was 0.735. In Post-SCV, the manual AUC was 0.779; the 3D U‑net was 0.736. No significant differences were found between manual and 3D U‑net for all results. Using a mobile PC, the average time taken to output the test data results was 30 s per case.

Conclusion: The proposed method is a simple, accurate, and clinically applicable; it can contribute to the widespread use of recurrence prediction scoring systems for CSDH.

目的:提出一种基于三维 U-net 的慢性硬膜下血肿(CSDH)自动分割计算血肿体积的方法,并研究该方法是否可用于临床预测复发。方法:使用术前和术后计算机断层扫描(CT)图像手动测量的血肿体积作为基本真实数据,对 200 名患者(400 份 CT 扫描)进行三维 U-net 训练。共有 215 名患者(430 次 CT 扫描)被用作测试数据,以输出训练好的 3D U-net 模型的分割结果。使用 Dice 分数分别评估术前和术后数据与基本真实数据的相似度。通过获得分割结果的接收者操作特征曲线(ROC)来评估复发预测的准确性。使用一台典型的移动 PC,测量每个病例的计算时间并计算平均时间:结果:测试数据的 Dice 评分中位数为术前血肿体积(Pre-HV)0.764,术后血肿体积(Pre-HV)0.764:0.764,术后硬膜下腔容积(Post-SCV):0.741:0.741.在评估复发预测的 ROC 分析中,Pre-HV 的手动曲线下面积 (AUC) 为 0.755,而 3D U-net 为 0.735。在脊髓灰质炎后,人工 AUC 为 0.779,三维 U 型网为 0.736。在所有结果中,手动和 3D U-net 没有发现明显差异。使用移动 PC,每个案例输出测试数据结果的平均时间为 30 秒:结论:所提出的方法简单、准确、适用于临床,有助于 CSDH 复发预测评分系统的广泛应用。
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引用次数: 0
Evaluation of Neonatal Cerebral Circulation Under Hypoxic Ischemic Risk Factors Based on Quantitative Analysis of Cerebral Veins with Magnetic Resonance Susceptibility Weighted Imaging. 基于磁共振感度加权成像脑静脉定量分析的缺氧缺血风险因素下的新生儿脑循环评估
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-26 DOI: 10.1007/s00062-024-01432-0
Qi Xie, Yan-Hui Liao, Wen-Juan He, Peng-Peng Han, Jun Wu

Purpose: To observe the regulation of cerebral circulation in vivo based on image segmentation algorithms for deep learning in medical imaging to automatically detect and quantify the neonatal deep medullary veins (DMVs) on susceptibility weighted imaging (SWI) images. To evaluate early cerebral circulation self-rescue for neonates undergoing risk of cerebral hypoxia-ischaemia in vivo.

Methods: SWI images and clinical data of 317 neonates with or without risk of cerebral hypoxia-ischaemia were analyzed. Quantitative parameters showing the number, width, and curvature of DMVs were obtained using an image segmentation algorithm.

Results: The number of DMVs was greater in males than in females (p < 0.01), and in term than in preterm infants (p = 0.001). The width of DMVs was greater in term than in preterm infants (p < 0.01), in low-risk than in high-risk group (p < 0.01), and in neonates without intracranial extracerebral haemorrhage (ICECH) than with ICECH (p < 0.05). The curvature of DMVs was greater in term than in preterm infants (P < 0.05). The width of both bilateral thalamic veins and anterior caudate nucleus veins were positively correlated with the number of DMVs; the width of bilateral thalamic veins was positively correlated with the width of DMVs.

Conclusion: The DMVs quantification based on image segmentation algorithm may provide more detailed and stable quantitative information in neonate. SWI vein quantification may be an observable indicator for in vivo assessment of cerebral circulation self-regulation in neonatal hypoxic-ischemic brain injury.

目的:基于医学影像深度学习的图像分割算法,观察体内脑循环的调节情况,自动检测和量化感性加权成像(SWI)图像上的新生儿深髓静脉(DMV)。评估体内新生儿脑缺氧缺血风险的早期脑循环自救情况:方法:分析 317 名有或没有脑缺氧缺血风险的新生儿的 SWI 图像和临床数据。使用图像分割算法获得了显示 DMV 数量、宽度和曲率的定量参数:结果:男性的 DMV 数量多于女性(P基于图像分割算法的 DMV 定量可为新生儿提供更详细、更稳定的定量信息。SWI静脉定量可作为体内评估新生儿缺氧缺血性脑损伤脑循环自我调节的观察指标。
{"title":"Evaluation of Neonatal Cerebral Circulation Under Hypoxic Ischemic Risk Factors Based on Quantitative Analysis of Cerebral Veins with Magnetic Resonance Susceptibility Weighted Imaging.","authors":"Qi Xie, Yan-Hui Liao, Wen-Juan He, Peng-Peng Han, Jun Wu","doi":"10.1007/s00062-024-01432-0","DOIUrl":"10.1007/s00062-024-01432-0","url":null,"abstract":"<p><strong>Purpose: </strong>To observe the regulation of cerebral circulation in vivo based on image segmentation algorithms for deep learning in medical imaging to automatically detect and quantify the neonatal deep medullary veins (DMVs) on susceptibility weighted imaging (SWI) images. To evaluate early cerebral circulation self-rescue for neonates undergoing risk of cerebral hypoxia-ischaemia in vivo.</p><p><strong>Methods: </strong>SWI images and clinical data of 317 neonates with or without risk of cerebral hypoxia-ischaemia were analyzed. Quantitative parameters showing the number, width, and curvature of DMVs were obtained using an image segmentation algorithm.</p><p><strong>Results: </strong>The number of DMVs was greater in males than in females (p < 0.01), and in term than in preterm infants (p = 0.001). The width of DMVs was greater in term than in preterm infants (p < 0.01), in low-risk than in high-risk group (p < 0.01), and in neonates without intracranial extracerebral haemorrhage (ICECH) than with ICECH (p < 0.05). The curvature of DMVs was greater in term than in preterm infants (P < 0.05). The width of both bilateral thalamic veins and anterior caudate nucleus veins were positively correlated with the number of DMVs; the width of bilateral thalamic veins was positively correlated with the width of DMVs.</p><p><strong>Conclusion: </strong>The DMVs quantification based on image segmentation algorithm may provide more detailed and stable quantitative information in neonate. SWI vein quantification may be an observable indicator for in vivo assessment of cerebral circulation self-regulation in neonatal hypoxic-ischemic brain injury.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"859-869"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subacute Degeneration of Fibers After Vertical Parasagittal Hemispherotomy. 垂直咽旁半球切除术后纤维的亚急性退化
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-25 DOI: 10.1007/s00062-024-01427-x
Markus Hittinger, Till Hartlieb, Dieter Henrik Heiland, Pamela Heiland, Tom Pieper, Martin Staudt, Ansgar Berlis, Manfred Kudernatsch, Irina Mader

Purpose: After vertical parasagittal hemispherotomy a restricted diffusion is often seen ipsilaterally and even distant from the adjacent resection margin. This retrospective cohort study analyses the anatomic site and the time course of the diffusion restriction after vertical parasagittal hemispherotomy.

Methods: Fifty-nine patients were included into this study, all of them having had one pre-operative and at least one post-operative MRI, including diffusion imaging at b‑values of 0 and 1000 s/mm2 with a calculated ADC.

Results: Diffusion restriction occurred exclusively on the operated site in all patients. In the basal ganglia, diffusion restriction was present in 37 of 38 patients at the first postoperative day with a duration of 38 days. In the midbrain, the posterior limb of the internal capsule and the thalamus, a restricted diffusion became postoperatively prominent at day 9 in all three localizations, with a duration of 36, 34 and 36 days, respectively. The incidence of thalamic lesions was lower if a preoperative damage had occurred.

Conclusion: The restricted diffusion in the basal ganglia resembles direct effects of the operation at its edges, whereas the later appearing diffusion restriction in the midbrain and the posterior limb of the internal capsule rather belong to a degeneration of the descending fibers being transected by the hemispherotomy in the sense of a Wallerian degeneration. The presence of preoperative hemispheric lesions influences the development of diffusion restriction at subacute fiber degeneration.

目的:垂直矢状旁半球切除术后,常在同侧甚至邻近切除边缘远处出现弥散受限。这项回顾性队列研究分析了垂直矢状旁半球切除术后弥散受限的解剖部位和时间过程:本研究共纳入 59 例患者,所有患者均进行过一次术前和至少一次术后磁共振成像,包括 b 值为 0 和 1000 s/mm2 的弥散成像,并计算 ADC:结果:所有患者的扩散受限均发生在手术部位。在基底节,38 名患者中有 37 名在术后第一天出现弥散受限,持续时间为 38 天。在中脑、内囊后缘和丘脑,术后第 9 天,这三个部位的弥散受限均变得明显,持续时间分别为 36 天、34 天和 36 天。如果术前存在损伤,丘脑病变的发生率较低:结论:基底节的扩散受限类似于手术在其边缘造成的直接影响,而中脑和内囊后缘较晚出现的扩散受限则属于半球切除术横断的下降纤维的变性,即沃勒氏变性。术前半球病变的存在会影响亚急性纤维变性扩散受限的发展。
{"title":"Subacute Degeneration of Fibers After Vertical Parasagittal Hemispherotomy.","authors":"Markus Hittinger, Till Hartlieb, Dieter Henrik Heiland, Pamela Heiland, Tom Pieper, Martin Staudt, Ansgar Berlis, Manfred Kudernatsch, Irina Mader","doi":"10.1007/s00062-024-01427-x","DOIUrl":"10.1007/s00062-024-01427-x","url":null,"abstract":"<p><strong>Purpose: </strong>After vertical parasagittal hemispherotomy a restricted diffusion is often seen ipsilaterally and even distant from the adjacent resection margin. This retrospective cohort study analyses the anatomic site and the time course of the diffusion restriction after vertical parasagittal hemispherotomy.</p><p><strong>Methods: </strong>Fifty-nine patients were included into this study, all of them having had one pre-operative and at least one post-operative MRI, including diffusion imaging at b‑values of 0 and 1000 s/mm<sup>2</sup> with a calculated ADC.</p><p><strong>Results: </strong>Diffusion restriction occurred exclusively on the operated site in all patients. In the basal ganglia, diffusion restriction was present in 37 of 38 patients at the first postoperative day with a duration of 38 days. In the midbrain, the posterior limb of the internal capsule and the thalamus, a restricted diffusion became postoperatively prominent at day 9 in all three localizations, with a duration of 36, 34 and 36 days, respectively. The incidence of thalamic lesions was lower if a preoperative damage had occurred.</p><p><strong>Conclusion: </strong>The restricted diffusion in the basal ganglia resembles direct effects of the operation at its edges, whereas the later appearing diffusion restriction in the midbrain and the posterior limb of the internal capsule rather belong to a degeneration of the descending fibers being transected by the hemispherotomy in the sense of a Wallerian degeneration. The presence of preoperative hemispheric lesions influences the development of diffusion restriction at subacute fiber degeneration.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"851-858"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiomics Analysis of Quantitative Maps from Synthetic MRI for Predicting Grades and Molecular Subtypes of Diffuse Gliomas. 对合成磁共振成像定量图进行放射组学分析,以预测弥漫性胶质瘤的分级和分子亚型。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-10 DOI: 10.1007/s00062-024-01421-3
Danlin Lin, Jiehong Liu, Chao Ke, Haolin Chen, Jing Li, Yuanyao Xie, Jianhua Ma, Xiaofei Lv, Yanqiu Feng

Purpose: To investigate the feasibility of using radiomics analysis of quantitative maps from synthetic MRI to preoperatively predict diffuse glioma grades, isocitrate dehydrogenase (IDH) subtypes, and 1p/19q codeletion status.

Methods: Data from 124 patients with diffuse glioma were used for analysis (n = 87 for training, n = 37 for testing). Quantitative T1, T2, and proton density (PD) maps were obtained using synthetic MRI. Enhancing tumour (ET), non-enhancing tumour and necrosis (NET), and peritumoral edema (PE) regions were segmented followed by manual fine-tuning. Features were extracted using PyRadiomics and then selected using Levene/T, BorutaShap and maximum relevance minimum redundancy algorithms. A support vector machine was adopted for classification. Receiver operating characteristic curve analysis and integrated discrimination improvement analysis were implemented to compare the performance of different radiomics models.

Results: Radiomics models constructed using features from multiple tumour subregions (ET + NET + PE) in the combined maps (T1 + T2 + PD) achieved the highest AUC in all three prediction tasks, among which the AUC for differentiating lower-grade and high-grade diffuse gliomas, predicting IDH mutation status and predicting 1p/19q codeletion status were 0.92, 0.95 and 0.86 respectively. Compared with those constructed on individual T1, T2, and PD maps, the discriminant ability of radiomics models constructed on the combined maps separately increased by 11, 17 and 10% in predicting glioma grades, 35, 52 and 19% in predicting IDH mutation status, and 16, 15 and 14% in predicting 1p/19q codeletion status (p < 0.05).

Conclusion: Radiomics analysis of quantitative maps from synthetic MRI provides a new quantitative imaging tool for the preoperative prediction of grades and molecular subtypes in diffuse gliomas.

目的:研究利用合成磁共振成像定量图的放射组学分析来术前预测弥漫性胶质瘤分级、异柠檬酸脱氢酶(IDH)亚型和 1p/19q 编码缺失状态的可行性:采用 124 名弥漫性胶质瘤患者的数据进行分析(87 人用于训练,37 人用于测试)。通过合成磁共振成像获得定量 T1、T2 和质子密度 (PD) 图。对增强肿瘤(ET)、非增强肿瘤和坏死(NET)以及瘤周水肿(PE)区域进行分割,然后进行手动微调。使用 PyRadiomics 提取特征,然后使用 Levene/T、BorutaShap 和最大相关性最小冗余算法进行选择。采用支持向量机进行分类。为了比较不同放射组学模型的性能,采用了接收者工作特征曲线分析和综合辨别改进分析:结果:利用联合图谱(T1 + T2 + PD)中多个肿瘤亚区(ET + NET + PE)的特征构建的放射组学模型在所有三项预测任务中都获得了最高的AUC,其中区分低级别和高级别弥漫性胶质瘤、预测IDH突变状态和预测1p/19q缺码状态的AUC分别为0.92、0.95和0.86。与根据单独的 T1、T2 和 PD 图谱构建的放射组学模型相比,根据组合图分别构建的放射组学模型在预测胶质瘤分级方面的判别能力分别提高了 11%、17% 和 10%,在预测 IDH 突变状态方面分别提高了 35%、52% 和 19%,在预测 1p/19q 编码缺失状态方面分别提高了 16%、15% 和 14%(p 结论):对合成磁共振成像定量图的放射组学分析为术前预测弥漫性胶质瘤的分级和分子亚型提供了一种新的定量成像工具。
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引用次数: 0
Stroke Evaluation in the Interventional Suite Using Dual-Layer Detector Cone-Beam CT: a First-in-human Prospective Cohort Study (the Next Generation X-ray Imaging System Trial). 在介入室使用双层探测器锥形束 CT 进行中风评估:首次人体前瞻性队列研究(下一代 X 射线成像系统试验)。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-07-25 DOI: 10.1007/s00062-024-01439-7
Fredrik Ståhl, Håkan Almqvist, Åsa Aspelin, Jens Kolloch, Odett Ghalamkari, Vamsi Gontu, Dirk Schäfer, Peter van de Haar, Klaus-Jürgen Engel, Fred van Nijnatten, Åke Holmberg, Michael V Mazya, Michael Söderman, Anna Falk Delgado

Purpose: Cone-beam CT in the interventional suite could be an alternative to CT to shorten door-to-thrombectomy time. However, image quality in cone-beam CT is limited by artifacts and poor differentiation between gray and white matter. This study compared non-contrast brain dual-layer cone-beam CT in the interventional suite to reference standard CT in stroke patients.

Methods: A prospective single-center study enrolled consecutive participants with ischemic or hemorrhagic stroke. The hemorrhage detection accuracy, per-region ASPECTS accuracy and subjective image quality (Likert scales for gray-white matter differentiation, structure perception and artifacts) were assessed by three neuroradiologists blinded to clinical data on dual-layer cone-beam CT 75 keV monoenergetic images compared to CT. Objective image quality was assessed by region-of-interest metrics. Non-inferiority for hemorrhage detection and ASPECTS accuracy was determined by the exact binomial test with a one-sided lower performance boundary prospectively set to 80% (98.75% CI).

Results: 27 participants were included (74 years ± 9; 19 female) in the hyperacute or acute stroke phase. One reader missed a small bleeding, but all hemorrhages were detected in the majority analysis (100% accuracy, CI lower boundary 86%, p = 0.002). ASPECTS majority analysis showed 90% accuracy (CI lower boundary 85%, p < 0.001). Sensitivity was 66% (individual readers 67%, 69%, and 76%), specificity was 97% (97%, 96%, 89%). Subjective and objective image quality were inferior to CT.

Conclusion: In a small single-center cohort, dual-layer cone-beam CT showed non-inferior hemorrhage detection and ASPECTS accuracy to CT. Despite inferior image quality, the technique may be useful for stroke evaluation in the interventional suite.

Trial registration number: NCT04571099 (clinicaltrials.gov). Prospectively registered 2020-09-04.

目的:介入手术室中的锥形束 CT 可以替代 CT,缩短从门诊到血栓切除术的时间。然而,锥束 CT 的图像质量受到伪影和灰质与白质区分度差的限制。本研究将介入治疗室的非对比脑双层锥形束 CT 与中风患者的参考标准 CT 进行了比较:一项前瞻性单中心研究连续招募了缺血性或出血性脑卒中患者。由三位神经放射科医生对双层锥形束 CT 75 keV 单能量图像与 CT 的临床数据进行盲法评估,比较出血检测准确性、每个区域 ASPECTS 准确性和主观图像质量(灰白质区分、结构感知和伪影的李克特量表)。客观图像质量通过感兴趣区指标进行评估。出血检测和 ASPECTS 准确性的非劣效性通过精确二项检验确定,单侧性能下限前瞻性设定为 80% (98.75% CI)。一名读者漏检了少量出血,但在多数分析中发现了所有出血(准确率 100%,CI 下限 86%,P = 0.002)。ASPECTS 多数分析的准确率为 90%(CI 下限为 85%,P=0.002):在一个小型单中心队列中,双层锥束 CT 的出血检测和 ASPECTS 准确率均不低于 CT。尽管图像质量较差,但该技术仍可用于介入治疗室的卒中评估:NCT04571099(clinicaltrials.gov)。前瞻性注册 2020-09-04。
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引用次数: 0
Endovascular Treatment of Large Core Infarcts: no Limits? 大面积核心梗塞的血管内治疗:无极限?
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1007/s00062-024-01472-6
Martin Bendszus
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引用次数: 0
Roles of Nontraditional Lipid Parameters for Predicting Restenosis in Patients with Intracranial Atherosclerotic Stenosis After Endovascular Treatment. 非传统血脂参数在预测血管内治疗后颅内动脉粥样硬化狭窄患者再狭窄中的作用
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-06-19 DOI: 10.1007/s00062-024-01409-z
Guoming Li, Xuecheng Cen, Zelan Ma, Fajun Chen

Purpose: Nontraditional lipid parameters are associated with intracranial atherosclerotic stenosis (ICAS) progression. This study aimed to investigate the association of nontraditional lipid parameters with the risk of restenosis in patients with ICAS after endovascular treatment (EVT).

Methods: This study retrospectively enrolled consecutive patients with symptomatic ICAS after successful EVT followed by at least 3 months of angiography. Participants were divided into restenosis or non-restenosis groups based on the angiographic follow-up results. The nontraditional lipid parameters were calculated from conventional lipid parameters. The COX regression models and restricted cubic splines (RCS) were used to explore the association between nontraditional lipid parameters and restenosis.

Results: This study recruited 222 cases with 224 lesions eligible for our study, of which 56 (25%) had restenosis. Compared with the non-restenosis group, patients in the restenosis group had higher levels of the atherogenic index of plasma (AIP) (0.211, interquartile range, IQR, 0.065-0.404 vs. 0.083, IQR, -0.052-0.265, P = 0.001), remnant cholesterol (RC) (0.55, IQR, 0.33-0.77 vs. 0.30, IQR, 0.18-0.49, P < 0.001) and Castelli's index‑I (CRI-I) (4.13, IQR, 3.39-5.34 vs. 3.74, IQR, 2.94-4.81, P = 0.030). In the multivariable COX regression analysis, a 0.1 unit increase of AIP was an independent risk factor for restenosis (hazard ratio, HR = 1.20, 95% confidence interval, CI 1.05-1.35, P = 0.005) whereas such an association was not observed for RC (HR = 1.01, 95% CI 0.90-1.15, P = 0.835). The restricted cubic spline (RCS) plot revealed a linear relationship between AIP and restenosis (P for nonlinear = 0.835) but a nonlinear relationship for RC (P for nonlinear = 0.012). Patients were stratified according to tertiles (T) of AIP and RC and the risk of restenosis increased in T3 compared to T1 (HR = 3.21, 95% CI 1.35-7.62, P = 0.008 and HR = 2.99, 95% CI 1.11-8.03, P = 0.030, respectively). Furthermore, this association remained stable within each LDL‑C level subgroup.

Conclusion: The AIP and RC were positively and independently associated with restenosis in patients with ICAS after EVT.

目的:非传统血脂参数与颅内动脉粥样硬化性狭窄(ICAS)进展有关。本研究旨在探讨非传统血脂参数与血管内治疗(EVT)后ICAS患者再狭窄风险的关系:该研究回顾性地连续招募了EVT成功后进行至少3个月血管造影的无症状ICAS患者。根据血管造影随访结果将患者分为再狭窄组和非再狭窄组。非传统血脂参数由传统血脂参数计算得出。采用 COX 回归模型和限制性立方样条(RCS)来探讨非传统血脂参数与再狭窄之间的关系:本研究共招募了 222 例病例,224 个病变符合我们的研究条件,其中 56 例(25%)发生了再狭窄。与非再狭窄组相比,再狭窄组患者的血浆致动脉粥样硬化指数(AIP)(0.211,四分位距,IQR,0.065-0.404 vs. 0.083,IQR,-0.052-0.265,P = 0.001)、残余胆固醇(RC)(0.55,IQR,0.33-0.77 vs. 0.30,IQR,0.18-0.49,P 结论:AIP 和 RC 与再狭窄呈正相关:AIP和RC与EVT后ICAS患者的再狭窄呈独立正相关。
{"title":"Roles of Nontraditional Lipid Parameters for Predicting Restenosis in Patients with Intracranial Atherosclerotic Stenosis After Endovascular Treatment.","authors":"Guoming Li, Xuecheng Cen, Zelan Ma, Fajun Chen","doi":"10.1007/s00062-024-01409-z","DOIUrl":"10.1007/s00062-024-01409-z","url":null,"abstract":"<p><strong>Purpose: </strong>Nontraditional lipid parameters are associated with intracranial atherosclerotic stenosis (ICAS) progression. This study aimed to investigate the association of nontraditional lipid parameters with the risk of restenosis in patients with ICAS after endovascular treatment (EVT).</p><p><strong>Methods: </strong>This study retrospectively enrolled consecutive patients with symptomatic ICAS after successful EVT followed by at least 3 months of angiography. Participants were divided into restenosis or non-restenosis groups based on the angiographic follow-up results. The nontraditional lipid parameters were calculated from conventional lipid parameters. The COX regression models and restricted cubic splines (RCS) were used to explore the association between nontraditional lipid parameters and restenosis.</p><p><strong>Results: </strong>This study recruited 222 cases with 224 lesions eligible for our study, of which 56 (25%) had restenosis. Compared with the non-restenosis group, patients in the restenosis group had higher levels of the atherogenic index of plasma (AIP) (0.211, interquartile range, IQR, 0.065-0.404 vs. 0.083, IQR, -0.052-0.265, P = 0.001), remnant cholesterol (RC) (0.55, IQR, 0.33-0.77 vs. 0.30, IQR, 0.18-0.49, P < 0.001) and Castelli's index‑I (CRI-I) (4.13, IQR, 3.39-5.34 vs. 3.74, IQR, 2.94-4.81, P = 0.030). In the multivariable COX regression analysis, a 0.1 unit increase of AIP was an independent risk factor for restenosis (hazard ratio, HR = 1.20, 95% confidence interval, CI 1.05-1.35, P = 0.005) whereas such an association was not observed for RC (HR = 1.01, 95% CI 0.90-1.15, P = 0.835). The restricted cubic spline (RCS) plot revealed a linear relationship between AIP and restenosis (P for nonlinear = 0.835) but a nonlinear relationship for RC (P for nonlinear = 0.012). Patients were stratified according to tertiles (T) of AIP and RC and the risk of restenosis increased in T3 compared to T1 (HR = 3.21, 95% CI 1.35-7.62, P = 0.008 and HR = 2.99, 95% CI 1.11-8.03, P = 0.030, respectively). Furthermore, this association remained stable within each LDL‑C level subgroup.</p><p><strong>Conclusion: </strong>The AIP and RC were positively and independently associated with restenosis in patients with ICAS after EVT.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"827-840"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thrombectomy Plus Intra-Arterial Thrombolysis Versus Thrombectomy for Acute Large Vessel Occlusions: a Matched-Control Study. 血栓切除术加动脉内溶栓与血栓切除术治疗急性大血管闭塞:一项匹配对照研究。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI: 10.1007/s00062-024-01431-1
Bin Han, Xu Tong, Raynald, Baixue Jia, Anxin Wang, Dapeng Mo, Feng Gao, Ning Ma, Zhongrong Miao

Aim: We conducted a matched-control analysis to compare the outcomes of large vessel occlusion (LVO) patients treated with mechanical thrombectomy (MT) plus Intra-arterial thrombolysis (IAT) versus those treated with MT alone.

Methods: The subjects of this study were chosen from ANGEL-ACT registry. All patients who received MT were identified and categorized into two groups: "MT + IAT" and "MT," based on whether or not they received additional intra-arterial medication IAT during the MT procedure. After being subjected to 1:1 propensity score matching, the outcome measures, including modified Rankin Scale (mRS) score at 90 days, successful recanalization at the final angiogram, symptomatic intracranial hemorrhage (sICH) within 36 h, and death within 90 days, were compared.

Results: The study encompassed a total of 1607 patients, with 641 individuals assigned to the MT + IAT group and 966 to the MT group. After applying propensity score matching, a total of 524 pairs were identified for comparison. The results indicated that there were no significant differences between the two groups with regard to the modified Rankin Scale (mRS) score (median: 3 vs. 3 points; P = 0.83), successful recanalization (89.9 vs. 88.9%; P = 0.62), sICH (8.3 vs. 8.7%; P = 0.79), and death (15.5 vs. 16.4%; P = 0.70).

Conclusions: IAT during MT does not confer an elevated risk of sICH or mortality. Furthermore, the combination of MT and IAT may produce comparable functional outcomes in comparison to MT alone, when treating acute LVO patients.

目的:我们进行了一项匹配对照分析,以比较接受机械血栓切除术(MT)和动脉内溶栓术(IAT)治疗的大血管闭塞(LVO)患者与仅接受机械血栓切除术治疗的患者的疗效:研究对象选自 ANGEL-ACT 登记处。方法:研究对象选自 ANGEL-ACT 登记册,所有接受 MT 治疗的患者均被识别并分为两组:"MT + IAT "组和 "MT "组,根据他们在 MT 过程中是否接受了额外的动脉内药物 IAT。在进行1:1倾向评分匹配后,对结果指标进行比较,包括90天时的改良Rankin量表(mRS)评分、最终血管造影时的成功再通率、36小时内的无症状性颅内出血(sICH)和90天内的死亡:研究共涉及1607名患者,其中641人被分配到MT + IAT组,966人被分配到MT组。在进行倾向得分匹配后,共确定了 524 对患者进行比较。结果显示,两组患者在改良Rankin量表(mRS)评分(中位数:3分 vs. 3分;P = 0.83)、成功再通(89.9% vs. 88.9%;P = 0.62)、sICH(8.3% vs. 8.7%;P = 0.79)和死亡(15.5% vs. 16.4%;P = 0.70)方面无显著差异:结论:MT期间的IAT不会导致sICH或死亡风险升高。此外,在治疗急性 LVO 患者时,联合使用 MT 和 IAT 可产生与单独使用 MT 相当的功能性结果。
{"title":"Thrombectomy Plus Intra-Arterial Thrombolysis Versus Thrombectomy for Acute Large Vessel Occlusions: a Matched-Control Study.","authors":"Bin Han, Xu Tong, Raynald, Baixue Jia, Anxin Wang, Dapeng Mo, Feng Gao, Ning Ma, Zhongrong Miao","doi":"10.1007/s00062-024-01431-1","DOIUrl":"10.1007/s00062-024-01431-1","url":null,"abstract":"<p><strong>Aim: </strong>We conducted a matched-control analysis to compare the outcomes of large vessel occlusion (LVO) patients treated with mechanical thrombectomy (MT) plus Intra-arterial thrombolysis (IAT) versus those treated with MT alone.</p><p><strong>Methods: </strong>The subjects of this study were chosen from ANGEL-ACT registry. All patients who received MT were identified and categorized into two groups: \"MT + IAT\" and \"MT,\" based on whether or not they received additional intra-arterial medication IAT during the MT procedure. After being subjected to 1:1 propensity score matching, the outcome measures, including modified Rankin Scale (mRS) score at 90 days, successful recanalization at the final angiogram, symptomatic intracranial hemorrhage (sICH) within 36 h, and death within 90 days, were compared.</p><p><strong>Results: </strong>The study encompassed a total of 1607 patients, with 641 individuals assigned to the MT + IAT group and 966 to the MT group. After applying propensity score matching, a total of 524 pairs were identified for comparison. The results indicated that there were no significant differences between the two groups with regard to the modified Rankin Scale (mRS) score (median: 3 vs. 3 points; P = 0.83), successful recanalization (89.9 vs. 88.9%; P = 0.62), sICH (8.3 vs. 8.7%; P = 0.79), and death (15.5 vs. 16.4%; P = 0.70).</p><p><strong>Conclusions: </strong>IAT during MT does not confer an elevated risk of sICH or mortality. Furthermore, the combination of MT and IAT may produce comparable functional outcomes in comparison to MT alone, when treating acute LVO patients.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"871-879"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Clinical Neuroradiology
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