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Measurement of Healthy Adult Brain Temperature Using 1H Magnetic Resonance Spectroscopy Thermometry. 利用 1H 磁共振波谱温度计测量健康成年人的脑温
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-10-30 DOI: 10.1007/s00062-024-01467-3
Yahong Tan, Wenjia Liu, Yanhua Li, Nan Zhang, Mingxiao Wang, Shuo Sun, Lin Ma

Purpose: The purpose of this study is to measure the brain temperature (Tbr) by using 1H magnetic resonance spectroscopy (1H MRS) thermometry and investigate its age and gender differences in healthy adults. The brain temperature was further compared with the body temperature (Tbo) to investigate the possible existence of brain-body temperature gradient (∆T).

Methods: A total of 80 subjects were included in this study. 1H MRS data were collected on a 3.0T MR scanner using Point Resolved Selective Spectroscopy (PRESS) sequence. Voxels were positioned in the right frontal (RF) lobe and left frontal (LF) lobe, respectively. The temperature of each voxel was calculated by chemical shift difference (∆δ) between H2O and NAA which was obtained by LCModel software. The average temperature of bilateral frontal lobe voxels was defined as Tbr for each subject. The average forehead temperature was acquired before MR scanning, defined as Tbo, in this study. The difference between Tbr and Tbo, denoted as the brain-body temperature gradient (∆T), was calculated. Age and gender characteristics of Tbr, ∆T and Tbo were analyzed.

Results: Tbr (38.51 ± 0.59℃) was higher than Tbo (36.47 ± 0.26℃) (P < 0.05). Negative correlations were observed between Tbr and age (r = -0.49, P < 0.05) and between ∆T and age (r = -0.44, P < 0.05), whereas no correlation existed between Tbo and age (r = -0.03, P = 0.79).

Conclusion: Our observation demonstrated that the brain temperature, derived from 1H MRS thermometry, is significantly higher than the body temperature, indicating the existence of a brain-body temperature gradient, and the brain temperature gradually decreases with age.

目的:本研究旨在利用1H磁共振波谱(1H MRS)测温法测量健康成年人的脑温(Tbr),并研究其年龄和性别差异。将脑温与体温(Tbo)进一步比较,以研究可能存在的脑-体温度梯度(∆T):本研究共纳入 80 名受试者。在 3.0T 磁共振扫描仪上使用点分辨选择性光谱(PRESS)序列收集 1H MRS 数据。体素分别位于右额叶(RF)和左额叶(LF)。每个体素的温度是通过 LCModel 软件获得的 H2O 和 NAA 化学位移差(Δδ)计算得出的。每个受试者双侧额叶体素的平均温度定义为 Tbr。在本研究中,前额的平均温度是在磁共振扫描前获得的,定义为 Tbo。计算 Tbr 和 Tbo 之间的差值,即脑-体温度梯度(∆T)。分析了 Tbr、∆T 和 Tbo 的年龄和性别特征:结果:Tbr(38.51 ± 0.59℃)高于 Tbo(36.47 ± 0.26℃)(P br 和年龄(r = -0.49,P bo 和年龄(r = -0.03,P = 0.79)):我们的观察结果表明,通过 1H MRS 测温得出的脑温明显高于体温,表明存在脑-体温度梯度,且脑温随着年龄的增长而逐渐降低。
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引用次数: 0
Inferior Vena Cava Thrombosis in the Setting of Lumbar Spondylodiscitis. 腰椎间盘炎导致的下腔静脉血栓形成
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-10-23 DOI: 10.1007/s00062-024-01466-4
Valeria Ortega, Alexander Levitt
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引用次数: 0
Freiburg Neuropathology Case Conference : Posterior fossa tumour 15 years after microsurgical resection of a cerebellar pilocytic astrocytoma. 弗莱堡神经病理学病例会议:小脑柔毛细胞星形细胞瘤显微手术切除15年后的后窝肿瘤。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-10-23 DOI: 10.1007/s00062-024-01468-2
M Schwabenland, L Becker, C J Gizaw, M Prinz, H Urbach, D Erny, C A Taschner
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引用次数: 0
Evaluation of an Image-based Classification Model to Identify Glioma Subtypes Using Arterial Spin Labeling Perfusion MRI On the Publicly Available UCSF Glioma Dataset. 在公开的加州大学旧金山分校胶质瘤数据集上评估使用动脉自旋标记灌注磁共振成像识别胶质瘤亚型的图像分类模型。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-10-17 DOI: 10.1007/s00062-024-01465-5
K Amador, H Kniep, J Fiehler, N D Forkert, T Lindner

Purpose: Glioma is a complex cancer comprising various subtypes and mutations, which may have different metabolic characteristics that can potentially be investigated and identified using perfusion imaging. Therefore, the aim of this work was to use radiomics and machine learning analysis of arterial spin labeling MRI data to automatically differentiate glioma subtypes and mutations.

Methods: A total of 495 Arterial Spin Labeling (ASL) perfusion imaging datasets from the UCSF Glioma database were used in this study. These datasets were segmented to delineate the tumor volume and classified according to tumor grade, pathological diagnosis, and IDH status. Perfusion image data was obtained from a 3T MRI scanner using pseudo-continuous ASL. High level texture features were extracted for each ASL dataset using PyRadiomics after tumor volume segmentation and then analyzed using a machine learning framework consisting of ReliefF feature ranking and logistic model tree classification algorithms.

Results: The results of the evaluation revealed balanced accuracies for the three endpoints ranging from 55.76% (SD = 4.28, 95% CI: 53.90-57.65) for the tumor grade using 25.4 ± 37.21 features, 62.53% (SD = 2.86, 95% CI: 61.27-63.78) for the mutation status with 23.3 ± 29.17 picked features, and 80.97% (SD = 1.83, 95% CI: 80.17-81.78) for the pathological diagnosis which used 47.3 ± 32.72 selected features.

Conclusions: Radiomics and machine learning analysis of ASL perfusion data in glioma patients hold potential for aiding in the diagnosis and treatment of glioma, mainly for discerning glioblastoma from astrocytoma, while performance for tumor grading and mutation status appears limited.

目的:胶质瘤是一种复杂的癌症,包括各种亚型和突变,它们可能具有不同的代谢特征,这些特征有可能通过灌注成像进行研究和识别。因此,这项工作旨在利用放射组学和机器学习分析动脉自旋标记磁共振成像数据,自动区分胶质瘤亚型和突变:本研究使用了加州大学旧金山分校胶质瘤数据库中的495个动脉自旋标记(ASL)灌注成像数据集。这些数据集经过分割以划分肿瘤体积,并根据肿瘤分级、病理诊断和 IDH 状态进行分类。灌注图像数据是使用伪连续 ASL 从 3T MRI 扫描仪上获得的。肿瘤体积分割后,使用 PyRadiomics 提取每个 ASL 数据集的高级纹理特征,然后使用由 ReliefF 特征排序和逻辑模型树分类算法组成的机器学习框架进行分析:评估结果表明,使用 25.4 ± 37.21 个特征对肿瘤分级进行分类的准确率为 55.76%(SD = 4.28,95% CI:53.90-57.65),对三个终点进行分类的准确率为 62.53%(SD = 2.86,95% CI:61.27-63.78),而病理诊断则使用了 47.3 ± 32.72 个选定特征:对胶质瘤患者的ASL灌注数据进行放射组学和机器学习分析,具有辅助胶质瘤诊断和治疗的潜力,主要用于鉴别胶质母细胞瘤和星形细胞瘤,而在肿瘤分级和突变状态方面的性能似乎有限。
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引用次数: 0
Factors Influencing the Association of 24-hour National Institutes of Health Stroke Scale & 90-day Modified Rankin Score. 影响 24 小时美国国立卫生研究院卒中量表与 90 天改良 Rankin 评分关联的因素。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-10-15 DOI: 10.1007/s00062-024-01459-3
Alexander Stebner, Salome L Bosshart, Andrew Demchuk, Alexandre Poppe, Raul Nogueira, Ryan McTaggart, Brian Buck, Aravind Ganesh, Michael Hill, Mayank Goyal, Johanna Ospel

Purpose: The modified Rankin Scale (mRS) at 90 days is the primary outcome in most acute stroke studies, but the long follow-up period has disadvantages. The National Institutes of Health Stroke Scale (NIHSS) at 24 h shows a strong, but imperfect, association with 90-day mRS. This study examines the association between 24-hour NIHSS and 90-day mRS and reasons for discrepancies.

Methods: Data are from the ESCAPE-NA1 thrombectomy patients. To address the non-normality distribution of the NIHSS and include deceased patients, a 7-point ordinal score was generated by grouping 24-hour NIHSS. The association of ordinal 24-hour NIHSS and 90-day mRS was assessed with adjusted ordinal logistic regression. Differences in baseline and treatment/post-treatment variables were compared between patients with discordant and concordant outcomes.

Results: One-thousand-seventy-six patients with available 24-hour NIHSS and 90-day mRS were included (median 24-hour NIHSS 6[IQR: 2-14], median 90-day mRS 2[IQR: 1-4]). Ordinal 24-hour NIHSS was associated with 90-day mRS (adjusted cOR 2.53 [95%CI 2.33-2.74]). Forty-eight (4.5%) patients had discordant outcomes. Of those, 19(1.8%) had 24-hour NIHSS < 6 and 90-day mRS5-6; all of which had ≥ 1 severe adverse event, most commonly pneumonia (6[31.6%]) or recurrent stroke (4[21.1%]). Twenty-nine patients (2.7%) had 24-hour NIHSS > 14 and 90-day mRS 0-2. In these patients, baseline NIHSS and ASPECTS was lower, and collateral status was worse.

Conclusion: An ordinal NIHSS score that includes death at 24 h shows a strong association with 90-day mRS, suggesting that it could be used as an alternative outcome. Patients with discrepant outcomes differed from the remaining patients regarding their baseline NIHSS, ASPECTS, collateral status, and post-stroke complications.

目的:大多数急性卒中研究的主要结果是 90 天的改良 Rankin 量表(mRS),但随访时间长有其缺点。美国国立卫生研究院卒中量表(NIHSS)24 小时评分与 90 天 mRS 的关联性很强,但并不完美。本研究探讨了 24 小时 NIHSS 与 90 天 mRS 之间的关联以及出现差异的原因:数据来自ESCAPE-NA1血栓切除术患者。为了解决 NIHSS 的非正态分布问题,并将死亡患者包括在内,对 24 小时 NIHSS 进行分组,得出 7 点序数分。通过调整后的序数逻辑回归评估了 24 小时 NIHSS 和 90 天 mRS 的相关性。比较了结果不一致和结果一致的患者在基线和治疗/治疗后变量方面的差异:共纳入了 176 名有 24 小时 NIHSS 和 90 天 mRS 资料的患者(24 小时 NIHSS 中位数为 6[IQR:2-14],90 天 mRS 中位数为 2[IQR:1-4])。24 小时 NIHSS 排序与 90 天 mRS 相关(调整后 cOR 为 2.53 [95%CI 2.33-2.74])。48例(4.5%)患者的结果不一致。其中,19 名患者(1.8%)的 24 小时 NIHSS 为 14,90 天 mRS 为 0-2。在这些患者中,基线 NIHSS 和 ASPECTS 较低,侧支状况较差:包括24小时死亡在内的NIHSS顺序评分与90天mRS有很强的相关性,这表明它可以作为一种替代结果。结果不一致的患者在基线 NIHSS、ASPECTS、侧支状态和卒中后并发症方面与其他患者不同。
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引用次数: 0
Thrombectomy Outcomes for Anterior Circulation Stroke in the 6-24 h Time Window Solely Based On NCCT and CTA: A Single Center Study. 仅根据 NCCT 和 CTA 在 6-24 小时时间窗内对前循环卒中进行血栓清除术的结果:单中心研究。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-10-01 DOI: 10.1007/s00062-024-01462-8
Dmytro Shchehlov, Stanislav Konotopchk, Valentyna Pankiv, Farida Rzayeva, Sergii Kolomiichenko, Mykola Vyval, Fabian Flottmann, Jens Fiehler, Anna A Kyselyova

Purpose: Since perfusion imaging may be unavailable in smaller hospitals, alternative imaging selection methods for acute ischemic stroke can improve outcomes and optimize resources. This study assessed the safety and effectiveness of using imaging criteria other than DEFUSE 3 and DAWN for thrombectomy beyond 6 h from symptom onset in patients stroke in the anterior circulation.

Methods: This is a retrospective, single-center analysis of consecutive patients with large vessel occlusion in the anterior circulation undergoing thrombectomy. Patients were categorized into two groups based on the collateral status (moderate collaterals and good collaterals).

Results: Among 198 patients, 106 (54%) met the inclusion criteria and were analyzed. Good collateral status was observed in 78 (74%) patients. Patients with good collaterals showed significantly lower mRS scores at discharge and at 90 days compared to their counterparts with moderate collateral status (4 (3-4) vs. 4 (4-5); p = 0.001 and 2 (0-4) vs. 6 (3-6); p < 0.001, respectively). More patients with good collateral status achieved favorable outcomes at 90 days compared to those with moderate status (48 (61.5%) vs. 5 (17.9%); p < 0.001). Good collaterals were an independent predictor of good clinical outcomes at 90 days (OR = 1.31, 95% CI: 1.13-1.53, p < 0.001).

Conclusion: Selecting patients for endovascular treatment of acute ischemic stroke using non-contrast CT and CT angiography shows 90-day outcomes similar to the DAWN and DEFUSE-3 trials. Using collateral status on CT angiography can predict favorable outcomes after mechanical thrombectomy in resource-limited settings where perfusion imaging is unavailable.

目的:由于小型医院可能无法提供灌注成像,急性缺血性卒中的其他成像选择方法可改善预后并优化资源。本研究评估了前循环卒中患者自症状出现起 6 小时后使用 DEFUSE 3 和 DAWN 以外的影像学标准进行血栓切除术的安全性和有效性:这是对连续接受血栓切除术的前循环大血管闭塞患者进行的单中心回顾性分析。根据侧支状况(中度侧支和良好侧支)将患者分为两组:在 198 名患者中,106 人(54%)符合纳入标准并接受了分析。78例(74%)患者的侧支状况良好。与中度侧支状态的患者相比,侧支状态良好的患者在出院时和90天后的mRS评分明显较低(4(3-4)分对4(4-5)分;p = 0.001和2(0-4)分对6(3-6)分;p 结论:选择接受血管内治疗的患者时应考虑到患者的具体情况:使用非对比 CT 和 CT 血管造影选择急性缺血性卒中血管内治疗患者的 90 天疗效与 DAWN 和 DEFUSE-3 试验相似。在资源有限、无法进行灌注成像的情况下,利用 CT 血管造影的侧支状态可以预测机械血栓切除术后的良好预后。
{"title":"Thrombectomy Outcomes for Anterior Circulation Stroke in the 6-24 h Time Window Solely Based On NCCT and CTA: A Single Center Study.","authors":"Dmytro Shchehlov, Stanislav Konotopchk, Valentyna Pankiv, Farida Rzayeva, Sergii Kolomiichenko, Mykola Vyval, Fabian Flottmann, Jens Fiehler, Anna A Kyselyova","doi":"10.1007/s00062-024-01462-8","DOIUrl":"https://doi.org/10.1007/s00062-024-01462-8","url":null,"abstract":"<p><strong>Purpose: </strong>Since perfusion imaging may be unavailable in smaller hospitals, alternative imaging selection methods for acute ischemic stroke can improve outcomes and optimize resources. This study assessed the safety and effectiveness of using imaging criteria other than DEFUSE 3 and DAWN for thrombectomy beyond 6 h from symptom onset in patients stroke in the anterior circulation.</p><p><strong>Methods: </strong>This is a retrospective, single-center analysis of consecutive patients with large vessel occlusion in the anterior circulation undergoing thrombectomy. Patients were categorized into two groups based on the collateral status (moderate collaterals and good collaterals).</p><p><strong>Results: </strong>Among 198 patients, 106 (54%) met the inclusion criteria and were analyzed. Good collateral status was observed in 78 (74%) patients. Patients with good collaterals showed significantly lower mRS scores at discharge and at 90 days compared to their counterparts with moderate collateral status (4 (3-4) vs. 4 (4-5); p = 0.001 and 2 (0-4) vs. 6 (3-6); p < 0.001, respectively). More patients with good collateral status achieved favorable outcomes at 90 days compared to those with moderate status (48 (61.5%) vs. 5 (17.9%); p < 0.001). Good collaterals were an independent predictor of good clinical outcomes at 90 days (OR = 1.31, 95% CI: 1.13-1.53, p < 0.001).</p><p><strong>Conclusion: </strong>Selecting patients for endovascular treatment of acute ischemic stroke using non-contrast CT and CT angiography shows 90-day outcomes similar to the DAWN and DEFUSE-3 trials. Using collateral status on CT angiography can predict favorable outcomes after mechanical thrombectomy in resource-limited settings where perfusion imaging is unavailable.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Artificial Intelligence Algorithm Integrated into the Clinical Workflow Can Ensure High Quality Acute Intracranial Hemorrhage CT Diagnostic. 融入临床工作流程的人工智能算法可确保高质量的急性颅内出血 CT 诊断。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-09-26 DOI: 10.1007/s00062-024-01461-9
K Villringer, R Sokiranski, R Opfer, L Spies, M Hamann, A Bormann, M Brehmer, I Galinovic, J B Fiebach

Purpose: Intracranial hemorrhage (ICH) is a life-threatening condition requiring rapid diagnostic and therapeutic action. This study evaluates whether Artificial intelligence (AI) can provide high-quality ICH diagnostics and turnaround times suitable for routine radiological practice.

Methods: A convolutional neural network (CNN) was trained and validated to detect ICHs on DICOM images of cranial CT (CCT) scans, utilizing about 674,000 individually labeled slices. The CNN was then incorporated into a commercial AI engine and seamlessly integrated into three pilot centers in Germany. A real-world test-dataset was extracted and manually annotated by two experienced experts. The performance of the AI algorithm against the two raters was assessed and compared to the inter-rater agreement. The overall time ranging from data acquisition to the delivery of the AI results was analyzed.

Results: Out of 6284 CCT examinations acquired in three different centers, 947 (15%) had ICH. Breakdowns of hemorrhage types included 8% intraparenchymal, 3% intraventricular, 6% subarachnoidal, 7% subdural, < 1% epidural hematomas. Comparing the AI's performance on a subset of 255 patients with two expert raters, it achieved a sensitivity of 0.90, a specificity of 0.96, an accuracy of 0.96. The corresponding inter-rater agreement was 0.84, 0.98, and 0.96. The overall median processing times for the three centers were 9, 11, and 12 min, respectively.

Conclusion: We showed that an AI algorithm for the automatic detection of ICHs can be seamlessly integrated into clinical workflows with minimal turnaround time. The accuracy was on par with radiology experts, making the system suitable for routine clinical use.

目的:颅内出血(ICH)是一种危及生命的疾病,需要快速诊断和治疗。本研究评估了人工智能(AI)能否提供高质量的 ICH 诊断和适合常规放射实践的周转时间:方法:对卷积神经网络(CNN)进行了训练和验证,以利用约 674,000 个单独标记的切片在头颅 CT(CCT)扫描的 DICOM 图像上检测 ICH。然后,CNN 被集成到一个商业人工智能引擎中,并无缝集成到德国的三个试点中心。两个经验丰富的专家提取了真实世界的测试数据集,并进行了人工标注。评估了人工智能算法在两位评分者面前的表现,并与评分者之间的一致性进行了比较。分析了从数据采集到提供人工智能结果的整个时间范围:在三个不同中心采集的 6284 例 CCT 检查中,947 例(15%)有 ICH。出血类型的分类包括:8%实质内出血、3%脑室内出血、6%蛛网膜下腔出血、7%硬膜下出血:我们的研究表明,用于自动检测 ICH 的人工智能算法可以无缝集成到临床工作流程中,而且周转时间极短。其准确性与放射科专家不相上下,因此该系统适合常规临床使用。
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引用次数: 0
Focally Enlarged Perivascular Spaces in Pediatric and Adolescent Patients with Polymicrogyria—an MRI Study 小儿和青少年多发性微小病变患者血管周围间隙局部增大--磁共振成像研究
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-09-13 DOI: 10.1007/s00062-024-01457-5
Maximilian Rauch, Karsten Lachner, Lea Frickel, Monika Lauer, Simon Jonas Adenauer, Elisabeth Neuhaus, Elke Hattingen, Luciana Porto

Purpose

Polymicrogyria (PMG) is a cortical malformation frequently associated with epilepsy. Our aim was to investigate the frequency and conspicuity of enlarged perivascular spaces (EPVS) underneath dysplastic cortex as a potentially underrecognized feature of PMG in pediatric and adolescent patients undergoing clinical magnetic resonance imaging (MRI).

Methods

We analyzed data from 28 pediatric and adolescent patients with PMG and a matched control group, ranging in age from 2 days to 21 years, who underwent MRI at 1.5T or 3T. T2-weighted MR images were examined for the presence of EPVS underneath the dysplastic cortex. The quantity of EPVS was graded from 0 to 4 (0: none, 1: < 10, 2: 11–20, 3: 21–40, 4: > 40 EPVS). We then compared the presence and quantity of EPVS to the matched controls in terms of total EPVS scores, and EPVS scores underneath the dysplastsic cortex depending on the age groups, the localization of PMG, and the MRI field strength.

Results

In 23/28 (82%) PMG patients, EPVS spatially related to the dysplastic cortex were identified. EPVS scores were significantly higher in PMG patients compared to controls, independent from age or PMG location. No significant differences were observed in EPVS scores in patients examined at 1.5T compared to those examined at 3T.

Conclusion

EPVS underneath the dysplastic cortex were identified in 82% of patients. EPVS may serve as an important clue for PMG and a marker for cortical malformation.

目的多发性癫痫(PMG)是一种经常与癫痫相关的皮质畸形。我们的目的是研究在接受临床磁共振成像(MRI)检查的儿童和青少年患者中,增生不良皮质下扩大的血管周围间隙(EPVS)的频率和显着性,因为这可能是 PMG 的一个未被充分认识的特征。方法我们分析了在 1.5T 或 3T 下接受磁共振成像检查的 28 名儿童和青少年 PMG 患者及匹配对照组的数据,他们的年龄从 2 天到 21 岁不等。T2加权磁共振图像检查了增生不良皮质下是否存在EPVS。EPVS 的数量从 0 到 4 分级(0:无;1:10;2:11-20;3:21-40;4:40 EPVS)。然后,我们根据年龄组、PMG的定位和磁共振成像场强,从EPVS总分和发育不良皮质下的EPVS得分两方面,比较了EPVS的存在和数量。与对照组相比,永磁发电机患者的EPVS评分明显较高,与年龄或永磁发电机位置无关。在1.5T下检查的患者与在3T下检查的患者在EPVS评分方面没有观察到明显差异。EPVS可作为 PMG 的重要线索和皮质畸形的标记。
{"title":"Focally Enlarged Perivascular Spaces in Pediatric and Adolescent Patients with Polymicrogyria—an MRI Study","authors":"Maximilian Rauch, Karsten Lachner, Lea Frickel, Monika Lauer, Simon Jonas Adenauer, Elisabeth Neuhaus, Elke Hattingen, Luciana Porto","doi":"10.1007/s00062-024-01457-5","DOIUrl":"https://doi.org/10.1007/s00062-024-01457-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Polymicrogyria (PMG) is a cortical malformation frequently associated with epilepsy. Our aim was to investigate the frequency and conspicuity of enlarged perivascular spaces (EPVS) underneath dysplastic cortex as a potentially underrecognized feature of PMG in pediatric and adolescent patients undergoing clinical magnetic resonance imaging (MRI).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We analyzed data from 28 pediatric and adolescent patients with PMG and a matched control group, ranging in age from 2 days to 21 years, who underwent MRI at 1.5T or 3T. T2-weighted MR images were examined for the presence of EPVS underneath the dysplastic cortex. The quantity of EPVS was graded from 0 to 4 (0: none, 1: &lt; 10, 2: 11–20, 3: 21–40, 4: &gt; 40 EPVS). We then compared the presence and quantity of EPVS to the matched controls in terms of total EPVS scores, and EPVS scores underneath the dysplastsic cortex depending on the age groups, the localization of PMG, and the MRI field strength.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>In 23/28 (82%) PMG patients, EPVS spatially related to the dysplastic cortex were identified. EPVS scores were significantly higher in PMG patients compared to controls, independent from age or PMG location. No significant differences were observed in EPVS scores in patients examined at 1.5T compared to those examined at 3T.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>EPVS underneath the dysplastic cortex were identified in 82% of patients. EPVS may serve as an important clue for PMG and a marker for cortical malformation.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seeing more than the Tip of the Iceberg: Approaches to Subthreshold Effects in Functional Magnetic Resonance Imaging of the Brain. 看到的不仅仅是冰山一角:大脑功能磁共振成像中的阈下效应研究方法。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-09-01 Epub Date: 2024-06-06 DOI: 10.1007/s00062-024-01422-2
Benedikt Sundermann, Bettina Pfleiderer, Anke McLeod, Christian Mathys

Many functional magnetic resonance imaging (fMRI) studies and presurgical mapping applications rely on mass-univariate inference with subsequent multiple comparison correction. Statistical results are frequently visualized as thresholded statistical maps. This approach has inherent limitations including the risk of drawing overly-selective conclusions based only on selective results passing such thresholds. This article gives an overview of both established and newly emerging scientific approaches to supplement such conventional analyses by incorporating information about subthreshold effects with the aim to improve interpretation of findings or leverage a wider array of information. Topics covered include neuroimaging data visualization, p-value histogram analysis and the related Higher Criticism approach for detecting rare and weak effects. Further examples from multivariate analyses and dedicated Bayesian approaches are provided.

许多功能磁共振成像(fMRI)研究和手术前绘图应用都依赖于大规模单变量推断和随后的多重比较校正。统计结果经常被可视化为阈值统计图。这种方法有其固有的局限性,包括仅根据通过此类阈值的选择性结果得出过度选择性结论的风险。本文概述了既有的和新出现的科学方法,通过纳入阈值下效应的信息来补充此类传统分析,从而改进对研究结果的解释或利用更广泛的信息。文章涉及的主题包括神经影像数据可视化、p 值直方图分析以及用于检测罕见和微弱效应的相关高级批判方法。此外,还提供了来自多元分析和专用贝叶斯方法的更多实例。
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引用次数: 0
Retrograde Parent Artery Occlusion for Ruptured Intracranial Vertebral Artery Dissecting Aneurysms Involving the Posterior Inferior Cerebellar Artery: The "Breakwater" Technique. 逆行母动脉闭塞术治疗涉及小脑后下动脉的颅内椎动脉破裂夹层动脉瘤:防波堤 "技术。
IF 2.8 3区 医学 Q2 Medicine Pub Date : 2024-09-01 Epub Date: 2024-02-02 DOI: 10.1007/s00062-024-01388-1
Satoshi Kitamura, Yoshiki Hanaoka, Jun-Ichi Koyama, Daisuke Yamazaki, Takuya Nakamura, Tetsuyoshi Horiuchi
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引用次数: 0
期刊
Clinical Neuroradiology
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