WITHDRAWN: Broadcasters, receivers, functional groups of metabolites and the link to heart failure using polygenic factors.

Azam Yazdani
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Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.

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广播者、接受者、代谢产物的功能组以及使用多基因因素与心力衰竭的联系。
在一项有心力衰竭(HF)发生率记录的前瞻性研究中,我们提供了基线时无HF个体的代谢物分析数据。我们使用数据驱动和多基因因素增强的因果网络揭示了代谢物的相互联系。通过探索这些网络,我们确定了与代谢物功能类别相对应的代谢物广播者、受体、介质和子网络,并深入了解了代谢组学结构与健康调节之间的联系。我们将网络结构纳入HF相关代谢物的鉴定中,以控制混杂代谢物的影响。我们确定了与HF发病率较高或较低相关的代谢物,这些相关性没有被其他代谢物混淆,如甘氨酸、脲基丙酸和甘胆酸,以及LPC 18:2。我们揭示了这些发现的潜在关系。例如,天冬酰胺直接影响甘氨酸,两者与HF呈负相关。这两种代谢产物受多基因因素的影响,仅受人体内未合成且直接来自饮食的必需氨基酸的影响。代谢产物可能在将遗传背景和生活方式因素与HF发病率联系起来方面发挥关键作用。揭示与HF相关的代谢产物的潜在连接性加强了研究结果,并促进了对HF过程的机制理解。
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