Effects of oral Mirtogenol on retinal ganglion cell apoptosis index and intraocular pressure in the Wistar glaucoma model.

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Advanced Pharmaceutical Technology & Research Pub Date : 2023-07-01 Epub Date: 2023-07-28 DOI:10.4103/japtr.japtr_29_23
Yustiadenta Widya Andika, Silka Roudhatul Jannah, Winarto, Arief Wildan, Fifin Luthfia Rahmi, Riski Prihatningtyas, Joko Mulyanto, Maharani
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Abstract

The purpose of this research is to determine how Mirtogenol affects intraocular pressure (IOP) and retinal ganglion cells (RGCs) of apoptosis index in Wistar glaucoma models, as well as the relationship between IOP and RGC apoptosis index. Twelve Wistar glaucoma models were divided into two groups for experimental research with a pretest-posttest and posttest-only. The treatment group got oral administration of Mirtogenol 12.3 mg twice a day for 2 weeks, whereas the control group received a placebo in the same way. Apoptotic index and IOP were evaluated both before and after the intervention. A parametric independent t-test was used to determine the difference between groups, and a parametric paired t-test was used to determine the difference within groups. The results showed that the RGC apoptosis index in treatment groups was considerably less when compared to control groups (P < 0.001). In the treatment group, the IOP is decreased compared to the control group (mean difference: -12.67 ± 3.79 vs. 0.69 ± 4.64, respectively, P = 0.002). A significant and solid correlation was found between IOP and RGC apoptosis index (R = 0.884, P < 0.001). Thus, Mirtogenol supplementation is expected to be used to prevent glaucoma progression.

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口服Mirtogenol对Wistar青光眼模型视网膜神经节细胞凋亡指数和眼压的影响。
本研究的目的是确定Mirtogenol如何影响Wistar青光眼模型中眼压(IOP)和视网膜神经节细胞(RGCs)的凋亡指数,以及IOP和RGCs凋亡指数之间的关系。将12个Wistar青光眼模型分为两组进行实验研究,分别进行前测后测和后测。治疗组口服米托烯醇12.3 mg,每天两次,持续2周,而对照组以同样的方式接受安慰剂。在干预前后评估凋亡指数和眼压。使用参数独立t检验来确定组之间的差异,使用参数配对t检验来判断组内的差异。结果显示,与对照组相比,治疗组的RGC凋亡指数显著降低(P<0.001)。治疗组的IOP与对照组比较有所下降(平均差异分别为:-12.67±3.79 vs.0.69±4.64,P=0.002)。IOP与RGC凋亡指数之间存在显著且坚实的相关性(R=0.884,P<0.001,Mirtogenol补充剂有望用于预防青光眼的进展。
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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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