Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice.

IF 2.4 4区医学 Q4 CELL & TISSUE ENGINEERING Regenerative medicine Pub Date : 2023-09-01 DOI:10.2217/rme-2022-0191

Jun Li, Yinghong Jiang, Wei Xue, Lejiang Liu, Hua Yu, Xuemei Zhang, Xiao Ye, Jianrong Miao, Jianling Liu, Yueen Chen, Xingbin Lan, Xiaoqing Liu, Wensong Yao, Jianchuan Sun, Jing Zheng, Jianzhong Xiao

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Abstract

Aim: This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. Methods: UCBMCs were injected once into the scrotal sheath cavity of elderly mice. Results: The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). Conclusion: Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.

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脐血单核细胞阴囊移植对老年小鼠性功能的影响。

目的:探讨同种异体脐带血单个核细胞(UCBMCs)阴囊移植对老年雄性小鼠性功能的影响。方法:老年小鼠阴囊鞘腔内一次性注射ucbmc。结果:移植的ucbmc在阴囊鞘腔内存活1个月。小鼠血睾酮浓度、环磷酸鸟苷(cGMP)水平和海肌体总一氧化氮合酶(T-NOS)活性显著升高，30分钟内小鼠交配次数增加(p = 0.000)。结论:阴囊植入ucbmc通过睾酮分泌和NOS/cGMP通路改善老年雄性小鼠性功能，可能为治疗勃起功能障碍提供一种创新的移植途径。

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来源期刊

Regenerative medicine 医学-工程：生物医学

CiteScore

4.20

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.