Redox dysregulation in imaging professionals occupationally exposed to ionizing and non-ionizing radiation.

IF 2.1 4区 医学 Q2 BIOLOGY International Journal of Radiation Biology Pub Date : 2024-01-01 Epub Date: 2023-09-13 DOI:10.1080/09553002.2023.2258194
Iman M Ahmad, Lisa Bartenhagen, Kimberly Michael, Maher Y Abdalla
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Abstract

Purpose: Imaging professionals are occupationally exposed to chronic ionizing radiation (IR) and non-ionizing radiation (NIR). This study aimed to investigate the influence of occupational radiation exposure on oxidative stress and antioxidant levels based on blood biomarkers in different hospital imaging professional groups.Materials and methods: The study groups included 66 imaging professionals occupationally exposed to IR (n = 58, 43 diagnostic radiography (G1), seven nuclear medicine (G2), eight radiation therapy (G3)), and NIR (n = 8, ultrasound imaging (G4)) and 60 non-exposed controls. Blood levels of superoxide (O2•-) as an index of oxidative stress, and the antioxidant activities of superoxide dismutase (SOD), glutathione ratio (GSH/GSSG), and catalase (CAT) were measured.Results: The blood values of O2•-, SOD, and CAT were significantly higher in imaging professionals occupationally exposed to radiation than in the control group (p < .05), while a significant decrease in the ratio of GSH/GSSG was observed (p < .05). The results from the NIR group were significantly higher compared to IR group.Conclusions: Based on these results, chronic exposure to radiation (IR and NIR) is associated with redox dysregulation that may result in damages to cellular biomolecules including lipids, proteins and DNA. Further studies are needed to determine the impact of redox dysregulation and the need for periodic examination among imaging professionals occupationally exposed to IR and NIR.

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职业暴露于电离和非电离辐射的成像专业人员的氧化还原失调。
目的:成像专业人员在职业上暴露于慢性电离辐射(IR)和非电离辐射(NIR)。本研究旨在基于不同医院影像专业人群的血液生物标志物,调查职业辐射暴露对氧化应激和抗氧化水平的影响。材料和方法:研究组包括66名职业暴露于IR(n=58,43名诊断性放射学(G1),7名核医学(G2),8名放射治疗(G3))和NIR(n=8,超声成像(G4))的成像专业人员和60名非暴露对照。测定血液中作为氧化应激指标的超氧化物(O2•-)水平,以及超氧化物歧化酶(SOD)、谷胱甘肽比(GSH/GSSG)和过氧化氢酶(CAT)的抗氧化活性。结果:职业暴露于辐射的成像专业人员的血液O2•-、SOD和CAT值显著高于对照组(p p结论:基于这些结果,长期暴露于辐射(IR和NIR)与氧化还原失调有关,氧化还原失调可能导致细胞生物分子(包括脂质、蛋白质和DNA)受损。需要进一步的研究来确定氧化还原失调的影响,以及在职业暴露于IR和NIR的成像专业人员中进行定期检查的必要性。
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来源期刊
CiteScore
5.00
自引率
11.50%
发文量
142
审稿时长
3 months
期刊介绍: The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.
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