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Value of 18F-FDG PET/CT-based radiomics features for differentiating primary lung cancer and solitary lung metastasis in patients with colorectal adenocarcinoma. 基于 18F-FDG PET/CT 的放射组学特征在区分结直肠腺癌患者的原发性肺癌和单发肺转移瘤方面的价值。
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-09-17 DOI: 10.1080/09553002.2024.2404465
Na Wang,Meng Dai,Fenglian Jing,Yunuan Liu,Yan Zhao,Zhaoqi Zhang,Jianfang Wang,Jingmian Zhang,Yingchen Wang,Xinming Zhao
OBJECTIVETo investigate the value and applicability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) radiomics in differentiating primary lung cancer (PLC) from solitary lung metastasis (SLM) in patients with colorectal cancer (CRC).MATERIALS AND METHODSThis retrospective study included 103 patients with CRC and solitary pulmonary nodules (SPNs). The least absolute shrinkage and selection operator (LASSO) was used to screen for optimal radiomics features and establish a PET/CT radiomics model. PET/CT Visual and complex models (combining radiomics with PET/CT visual features) were developed. The area under the receiver operating characteristic (ROC) curve (AUC) was used to determine the predictive value and diagnostic efficiency of the models.RESULTSThe AUC of the PET/CT radiomics model for differentiating PLC from SLM was 0.872 (95% CI: 0.806-0.939), which was not different from that of the visual (0.829 [95% CI: 0.749-0.908; p = .352]). However, the AUC of the complex model (0.936 [95% CI:0.892-0.981]) was significantly higher than that of the PET/CT radiomics (p = .005) and visual model (p = .001). The sensitivity (SEN), specificity (SPE), accuracy (ACC), positive predictive value (PPV), and negative predictive value (NPV) of PET/CT radiomics for differentiating PLC from SLM were 0.720, 0.887, 0.806, 0.857, and 0.770, respectively.CONCLUSIONPET/CT radiomics can effectively distinguish PLC and SLM in patients with CRC and SPNs and guide the implementation of personalized treatment.
材料和方法:这项回顾性研究纳入了 103 名患有结直肠癌(CRC)和单发肺结节(SPN)的患者。采用最小绝对收缩和选择算子(LASSO)筛选最佳放射组学特征,并建立 PET/CT 放射组学模型。建立了 PET/CT 视觉模型和复杂模型(将放射组学与 PET/CT 视觉特征相结合)。结果PET/CT放射组学模型区分PLC和SLM的AUC为0.872(95% CI:0.806-0.939),与视觉模型的AUC(0.829 [95% CI:0.749-0.908;p = .352])无异。然而,复合模型的AUC(0.936 [95% CI:0.892-0.981])明显高于PET/CT放射组学模型(p = .005)和视觉模型(p = .001)。PET/CT放射组学区分PLC和SLM的灵敏度(SEN)、特异度(SPE)、准确度(ACC)、阳性预测值(PPV)和阴性预测值(NPV)分别为0.720、0.887、0.806、0.857和0.770。
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引用次数: 0
Differential biological effect of low doses of ionizing radiation depending on the radiosensitivity in a cell line model 低剂量电离辐射的生物效应因细胞系模型的辐射敏感性而异
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-09-17 DOI: 10.1080/09553002.2024.2400514
Elia Palma-Rojo, Joan-Francesc Barquinero, Jaime Pérez-Alija, Juan R. González, Gemma Armengol
Exposure to low doses (LD) of ionizing radiation (IR), such as the ones employed in computed tomography (CT) examination, can be associated with cancer risk. However, cancer development could depen...
暴露于低剂量(LD)电离辐射(IR)(如计算机断层扫描(CT)检查中使用的辐射)可能与癌症风险有关。然而,癌症的发生可能取决于...
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引用次数: 0
Long-term biological effects after acute 131I-administration of two rat models (with and without thyroid). 两种大鼠模型(有甲状腺和无甲状腺)急性服用 131I 后的长期生物效应。
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-09-11 DOI: 10.1080/09553002.2024.2400484
Meriem Mezaguer-Lekouaghet,Maâmar Souidi,Samia Hadjrabia,Saâdia Mameri,Mounir Aït-Ziane,Abdelwahab Badreddine,Ahcène Baz,Zohra Lounis-Mokrani
PURPOSERadioiodine-131 (RAI or iodine-131) is one of the most frequently used radionuclides for diagnosis and therapy of thyroid diseases (90% of all therapies in nuclear medicine). In order to optimize the patient protection, it is important to evaluate the long-term biological effects of RAI therapy on non-target organs.MATERIALS AND METHODSAn experimental animal model has been adopted, it consists on miming RAI therapy. An activity of RAI has been administrated in two models of Wistar rats: the first model with an intact thyroid gland (Thy + model), and the second one was thyroidectomized (Thy- model). For each model, 6 rats were orally contaminated with a solution 18.5 ± 1MBq of [131I]NaI and 6 others rats were used as controls. The 24 rats have been placed in individual cages for a period of 08 months then they were euthanized. The blood was collected by cardiac puncture and all organs were immediately removed. A fraction of thyroid, liver, kidneys and testicles was put in vials containing formaldehyde (10%) for histological investigation.RESULTSHistological observations show some liver disorders more accentuated in the case of the Thy- model, the appearance of kidney tissue effects (hemosiderin deposits, fibrosis and glomerular necrosis) for both models and an absence of any anomaly for the testicles slides. The disturbance of blood parameters specific to each organ has been revealed.CONCLUSIONSLong-term biological effect of 131I-administration shows the appearance of various histological disorders confirmed by disturbances in hepatic and renal functions.
目的放射性碘-131(RAI 或碘-131)是诊断和治疗甲状腺疾病最常用的放射性核素之一(占核医学所有疗法的 90%)。为了优化对患者的保护,必须评估 RAI 治疗对非靶器官的长期生物影响。在两种 Wistar 大鼠模型中施用 RAI:第一种是甲状腺完整的模型(Thy + 模型),第二种是甲状腺切除的模型(Thy- 模型)。在每个模型中,6 只大鼠口服 18.5 ± 1MBq [131I]NaI 溶液,另外 6 只作为对照组。这 24 只大鼠被单独关在笼子里 08 个月后被安乐死。通过心脏穿刺采集血液,并立即切除所有器官。结果组织学观察显示,甲状腺模型的肝脏病变更为严重,两种模型的肾脏组织都出现了影响(血色素沉积、纤维化和肾小球坏死),而睾丸切片没有任何异常。结论131I 给药的长期生物效应显示出现了各种组织学紊乱,肝脏和肾脏功能紊乱也证实了这一点。
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引用次数: 0
The elicitation effects of diode and He-Ne laser irradiations on the alleviation of nutrient-deficiency induced damage in anthocyanin-producing red-fleshed apple cell suspension. 二极管激光和氦氖激光辐照对减轻花青素生产红肉苹果细胞悬浮液中营养缺乏引起的损伤的激发效应。
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-09-11 DOI: 10.1080/09553002.2024.2398083
Hashem Kazemzadeh-Beneh,Ebrahim Safari,Fariborz Zaare-Nahandi,Nasser Mahna
PURPOSEWe explored the elicitation role of the laser irradiations on the alleviation of nutrient-deficiency induced damage in anthocyanin-producing red-fleshed apple cell suspension in continuous production of anthocyanin.METHODSAnthocyanin-producing red-fleshed apple cells were irradiated by 4 intensity levels of red He-Ne (RHNL) and blue diode (BDL) lasers for 20 min.RESULTSNutrient deficiency indicated negative effect on total soluble proteins (TSP), superoxidase dismutase (SOD) activity, and total phenolics content (TPC) while it displayed a positive effect on malondialdehyde (MDA), total flavonoids content (TFC), O2-, H2O2-, and lipoxygenase (LOX) and polyphenol oxidase (PPO) activities in light controls, illustrating oxidative stress. The laser irradiations on suspension cells indicated variable effects on measured parameters and were time of growth-, levels of intensity-, and laser type-dependent. Likewise, the elicitation effects of lasers relied on a critical threshold among ROS generation and antioxidative system which determines the fate of cells against oxidative stress. The same trend was displayed by RHNL at 6.46 mWcm-2 intensity and BDL at 13.73 mWcm-2. These intensities resulted in a significant increase in SOD, APX, POD, and CAT activities and TSP, TPC, TFC, proline, and glycine betaine accumulation, while induced decrease in LOX, and PPO activities and MDA, and ROS generation, alleviating cellular injury from prolonged nutrient deficiency by diminishing lipid peroxidation and oxidative damages of cell membrane.CONCLUSIONResults suggested that lasers application on mitigating nutrient deficiency stress relied on establishing a suitable balance between ROS generation and antioxidative system, which enables the nutrient-starved anthocyanin-producing cells to continuously produce anthocyanin.
目的我们探讨了在连续生产花青素的过程中,激光辐照对减轻花青素生产红肉苹果细胞悬浮液中营养缺乏引起的损伤的诱导作用。方法用 4 种强度的红色氦氖激光(RHNL)和蓝色二极管激光(BDL)辐照花青素生产红肉苹果细胞 20 分钟。结果营养素缺乏对光照对照组的总可溶性蛋白(TSP)、超氧化物歧化酶(SOD)活性和总酚含量(TPC)有负面影响,而对光照对照组的丙二醛(MDA)、总黄酮含量(TFC)、O2-、H2O2-、脂氧合酶(LOX)和多酚氧化酶(PPO)活性有正面影响,说明存在氧化应激。激光照射悬浮细胞对测量参数的影响各不相同,且与生长时间、强度水平和激光类型有关。同样,激光的激发效应依赖于 ROS 生成和抗氧化系统之间的临界阈值,该阈值决定了细胞对抗氧化应激的命运。强度为 6.46 mWcm-2 的 RHNL 和强度为 13.73 mWcm-2 的 BDL 也显示了同样的趋势。这些强度导致 SOD、APX、POD 和 CAT 活性以及 TSP、TPC、TFC、脯氨酸和甘氨酸甜菜碱积累显著增加,同时诱导 LOX 和 PPO 活性以及 MDA 和 ROS 生成减少,通过减少脂质过氧化和细胞膜氧化损伤减轻了长期营养缺乏对细胞的伤害。结论结果表明,激光在缓解营养缺乏应激方面的应用依赖于在 ROS 生成和抗氧化系统之间建立适当的平衡,从而使营养缺乏的花青素生成细胞能够持续生成花青素。
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引用次数: 0
Gamma-rays induced genome wide stable mutations in cowpea deciphered through whole genome sequencing 通过全基因组测序破译伽马射线诱导的豇豆全基因组稳定突变
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2024-04-29 DOI: 10.1080/09553002.2024.2345087
Dhanasekar Punniyamoorthy, Jegadeesan Souframanien
Gamma rays are the most widely exploited physical mutagen in plant mutation breeding. They are known to be involved in the development of more than 60% of global cowpea (Vigna unguiculata (L.) Walp...
伽马射线是植物突变育种中利用最广泛的物理诱变剂。据了解,全球 60% 以上的豇豆(Vigna unguiculata (L.) Walp...
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引用次数: 0
Effect of changing the radiation dose range on the in vitro cytogenetic dose response to gamma-rays 改变辐射剂量范围对伽马射线体外细胞遗传剂量反应的影响
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2024-04-22 DOI: 10.1080/09553002.2024.2338511
Volodymyr A. Vinnikov
To examine the distortion of the linear quadratic (LQ) model of in vitro cytogenetic dose response over an extended range of γ-ray doses by analyzing the available literature data, and to establish...
通过分析现有的文献数据,研究体外细胞遗传剂量反应的线性二次方(LQ)模型在更大的γ射线剂量范围内的失真,并建立...
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引用次数: 0
Reasons why the idea that radiation exposures induce cancer needs to be revisited 需要重新审视辐照诱发癌症这一观点的原因
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2024-04-22 DOI: 10.1080/09553002.2024.2338516
Nori Nakamura
It has long been thought that the carcinogenic effect of radiation resulted from the induction of oncogenic mutations which then led to an increase in the proportion of cancer-bearing individuals. ...
长期以来,人们一直认为辐射的致癌作用源于诱导致癌突变,进而导致癌症患者比例增加。...
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引用次数: 0
Comparative study of the anti-inflammatory activity of etoricoxib and Matcha green tea against acute kidney injury induced by gamma radiation in rats 依托考昔和抹茶绿茶对伽马射线诱导的大鼠急性肾损伤的抗炎活性比较研究
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2024-04-22 DOI: 10.1080/09553002.2024.2338515
Sahar Khateeb, Eman F.S. Taha
The primary objective of this study was to conduct a comparative analysis of the anti-inflammatory activity between Etoricoxib (ETO) and Matcha green tea (MG) in the context of acute kidney injury ...
本研究的主要目的是比较分析埃托昔布(ETO)和抹茶绿茶(MG)在急性肾损伤中的抗炎活性。
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引用次数: 0
Meeting report: the 66th annual meeting of the Japanese Radiation Research Society in Tokyo, Japan, 6–8 November 2023 会议报告:2023 年 11 月 6 日至 8 日在日本东京举行的日本辐射研究学会第 66 届年会
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2024-04-17 DOI: 10.1080/09553002.2024.2338514
Haruka Izawa, Yuzuki Nakamura, Shinya Yokomizo, Masaru Takabatake
The 66th Annual Meeting of the Japanese Radiation Research Society took place in Tokyo, Japan, from 6 to 8 November 2023. The meeting covered a wide range of radiation research topics, including ba...
日本辐射研究学会第 66 届年会于 2023 年 11 月 6 日至 8 日在日本东京举行。此次会议涵盖了广泛的辐射研究课题,其中包括辐照度和辐照强度。
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引用次数: 0
Mitochondrial reactive oxygen species impact human fibroblast responses to protracted γ-ray exposures 线粒体活性氧影响人类成纤维细胞对长期γ射线照射的反应
IF 2.6 4区 医学 Q2 Medicine Pub Date : 2024-04-17 DOI: 10.1080/09553002.2024.2338518
Luke A. Whitcomb, Xu Cao, Dilip Thomas, Claudia Wiese, Alissa S. Pessin, Robert Zhang, Joseph C. Wu, Michael M. Weil, Adam J. Chicco
Purpose: Continuous exposure to ionizing radiation at a low dose rate poses significant health risks to humans on deep space missions, prompting the need for mechanistic studies to identify counter...
目的:持续暴露于低剂量率的电离辐射对执行深空任务的人类健康构成重大风险,因此需要进行机理研究,以确定应对措施。
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引用次数: 0
期刊
International Journal of Radiation Biology
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