Mean arterial pressure and mortality in patients with heart failure: a retrospective analysis of Zigong heart failure database.

IF 1.2 4区医学 Q4 PERIPHERAL VASCULAR DISEASE Blood Pressure Monitoring Pub Date : 2023-12-01 Epub Date: 2023-09-14 DOI:10.1097/MBP.0000000000000674

Hangkun Ma, Haibo Li, Song Sheng, Longfang Quan, Zhixu Yang, Fengqin Xu, Wenying Zeng

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Abstract

Background: It is commonly observed that a higher target of mean arterial pressure (MAP) is in previous studies. This study assessed the association of MAP with short-term mortality in heart failure (HF) patients.

Methods: A retrospective cohort study was conducted by using data from Hospitalized patients with heart failure: integrating electronic healthcare records and external outcome database (v1.2 ). The characteristic of patients was described by 3 groups of MAP: below 80 mmHg, 80-100 mmHg, and above 100 mmHg. Univariate and multivariate logistic regression analyses were used to assess the relevance between MAP and all-cause mortality within 28 days and 6 months. For assessing the effect of multiple variables on patient survival time, 28-day and 6-month, Kaplan-Meier survival analysis and Forest plot were performed.

Results: The overall cohort comprised 2008 patients divided by MAP into 3 groups, each group had 344 (17.1%), 938 (46.7%), and 726 (36.2%) patients. Patients in MAP < 80 mmHg group had higher mortality than MAP 80-100 mmHg and MAP ≥ 100 mmHg in 28 days(3.8% versus 1.6% versus 1.2%) and in 6 months (4.9% versus 2.5% versus 2.3%). Univariate analysis showed that MAP as a continuous variate was associated with 28-day (OR was 0.98, 95% CIs: 0.96-0.99, P = 0.011) and 6-month mortality (OR was 0.98, 95% CIs: 0.97-1, P = 0.021) in HF patients. Model 4 put into multivariate logistic regression analyses showed MAP 80-100 mmHg (OR was 0.13, 95% CIs: 0.02-0.8, P = 0.027) stably associated with 28-day and 6-month mortality after adjusted covariable. Kaplan-Meier survival curves revealed a higher survival rate in the MAP ≥ 80 mmHg group than in the MAP < 80 mmHg group. The forest plot showed the stable effect of MAP ≥ 80 mmHg compared with MAP < 80 mmHg, the interaction analysis had no statistical significance effect between the two groups of MAP and multi-variable.

Conclusion: It is indicated that MAP was independently associated with 28-day, 6-month all-cause mortality of HF patients, and compared with MAP < 80 mmHg, MAP ≥ 80 mmHg had a lower risk of 28-day, 6-month all-cause mortality of patients with HF.

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心力衰竭患者的平均动脉压和死亡率：自贡市心力衰竭数据库的回顾性分析。

背景：在以前的研究中，通常观察到平均动脉压（MAP）的目标更高。本研究评估了MAP与心力衰竭（HF）患者短期死亡率的关系。方法：使用心力衰竭住院患者的数据进行回顾性队列研究：整合电子医疗记录和外部结果数据库（v1.2）。患者的特征由3组MAP描述：低于80 mmHg，80-100 mmHg，且高于100 mmHg。使用单变量和多变量逻辑回归分析来评估MAP与28天和6个月内全因死亡率之间的相关性。为了评估多个变量对患者28天和6个月生存时间的影响，进行了Kaplan-Meier生存分析和Forest图。结果：整个队列包括2008名患者，按MAP分为3组，每组有344名（17.1%）、938名（46.7%）和726名（36.2%）患者。MAP患者结论：MAP与HF患者28天、6个月的全因死亡率独立相关，并与MAP比较

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来源期刊

Blood Pressure Monitoring 医学-外周血管病

CiteScore

2.00

自引率

7.70%

发文量

110

审稿时长

>12 weeks

期刊介绍： Blood Pressure Monitoring is devoted to original research in blood pressure measurement and blood pressure variability. It includes device technology, analytical methodology of blood pressure over time and its variability, clinical trials - including, but not limited to, pharmacology - involving blood pressure monitoring, blood pressure reactivity, patient evaluation, and outcomes and effectiveness research. This innovative journal contains papers dealing with all aspects of manual, automated, and ambulatory monitoring. Basic and clinical science papers are considered although the emphasis is on clinical medicine. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.