Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study.

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Journal of Obesity Pub Date : 2021-07-14 eCollection Date: 2021-01-01 DOI:10.1155/2021/9968730

Farzin Firozian, Amir Nili-Ahmadabadi, Shirin Moradkhani, Miad Moulaei, Zohreh Fasihi, Davoud Ahmadimoghaddam

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引用次数: 7

Abstract

Background: Some anorexic agents are used to fraudulent augmentation herbal weight loss formulations. This study was designed to evaluate the potential existence of illicit substances in 63 herbal weight loss formulations collected from local apothecaries in Hamadan, Iran.

Methods: The thin-layer chromatography method was applied for the primary screening of potential illicit substances in the samples. The positive samples were analyzed using an isocratic high-performance liquid chromatography method.

Results: The results showed that 26.98% of the samples contained 17.76 ± 6.02 mg/cap of sibutramine. Daily therapeutic dose intake of sibutramine is in the range of 5 to 15 mg daily.

Conclusion: Since apothecaries have advised consumers to take at least two capsules a day, it seems that the blood concentration of sibutramine will likely rise beyond the therapeutic concentration and become toxic. Therefore, the usage of such products could pose serious risks to consumers' health.

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非法添加合成抗肥胖药物对草药减肥产品的掺假:一项初步研究。

背景：一些厌食剂被用于欺骗性的增强草药减肥配方。这项研究旨在评估从伊朗哈马丹当地药剂师那里收集的63种草药减肥配方中是否存在非法物质。方法：采用薄层色谱法对样品中潜在的非法物质进行初步筛选。阳性样品采用等度高效液相色谱法进行分析。结果：26.98%的样品中含有17.76 ± 6.02 mg/cap西布曲明。西布曲明的每日治疗剂量摄入量在5至15的范围内 mg每日。结论：由于药剂师建议消费者每天至少服用两粒胶囊，血液中西布曲明的浓度似乎会超过治疗浓度并变得有毒。因此，使用此类产品可能对消费者的健康构成严重风险。

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来源期刊

Journal of Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

21 weeks

期刊介绍： Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.