Salivary biomarkers present in patients with periodontitis without clinical distinction: findings from a meta-analysis.

P-R Gomes, M-D Rocha, J-A Lira, F-A Coelho, E-H Alves, H-M Nascimento, S-M Oliveira, R-R Carmo, H-T Araújo, F-R Silva, D-F Vasconcelos
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Abstract

Background: A new classification for periodontitis has been adopted in clinical practice. However, there are still discussions regarding this new classification and difficulties in its adoption, both by professionals and researchers. Thus, this study aimed to evaluate which salivary biomarkers are present in periodontitis, following the new classification of periodontal diseases through meta-analysis.

Material and methods: A literature search was carried out in the scientific databases: PubMed, Scielo and Google scholar to select studies. The selection of studies was followed by two authors upon reading of the title, abstract and full text. The necessary data were collected and statistical analyses were performed using the Review Manager statistical software version 5.4, with calculation of Mean Difference, heterogeneity (I²) and funnel plot with P < 0.05.

Results: After following the selection criteria, 9 articles were selected for comparison. The studies address the presence of biomarkers in the saliva of patients with periodontitis and their possible use in the monitoring and diagnosis of the disease. For the meta-analytic comparison, a sample size of 1,983 individuals was used. Statistical analyses showed that nitric oxide, IL-6, IL-1B and osteoprotegerin are substances that are significantly present in patients with periodontitis (P < 0.05).

Conclusions: IL-6, nitric oxide, IL-1B, TNF-α and osteoprotegerin are among the most present biomarkers in patients with periodontitis, and may be used in the future as a monitoring of periodontal disease. The present study also revealed that there was no statistically significant difference in the concentration of these biomarkers for clinical distinction from periodontitis.

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牙周炎患者的唾液生物标志物无临床区别:来自荟萃分析的发现。
背景:临床上采用了一种新的牙周炎分类方法。然而,专业人士和研究人员仍然在讨论这种新的分类和采用它的困难。因此,本研究旨在通过荟萃分析评估牙周病新分类后,哪些唾液生物标志物存在于牙周炎中。材料和方法:在科学数据库PubMed、Scielo和Google scholar中进行文献检索,选择研究。两位作者在阅读标题、摘要和全文后选择了研究。收集必要资料,采用Review Manager统计软件5.4版进行统计分析,计算Mean Difference、异质性(I²)和漏斗图,P < 0.05。结果:按照筛选标准筛选出9篇文献进行比较。这些研究解决了牙周炎患者唾液中生物标志物的存在及其在疾病监测和诊断中的可能应用。为了进行meta分析比较,使用了1983个个体的样本量。统计分析显示,牙周炎患者血清中一氧化氮、IL-6、IL-1B、骨保护素含量显著升高(P < 0.05)。结论:IL-6、一氧化氮、IL-1B、TNF-α和骨保护素是牙周炎患者中最常见的生物标志物,未来可能用于牙周病的监测。本研究还显示,这些生物标志物的浓度与牙周炎的临床区别没有统计学意义。
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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