Pharma — manufacturing: the unappreciated and overlooked indispensable skill

IF 6.6 2区 医学 Q1 IMMUNOLOGY Current Opinion in Immunology Pub Date : 2023-10-01 DOI:10.1016/j.coi.2023.102385
Jenik Radon , Grace Pan
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Abstract

The process of vaccine production, manufacturing, is time-intensive, complex, expensive, and highly technical, requiring close coordination and collaboration among multiple companies with different inputs, from active pharmaceutical ingredients to glass, and specializations, and with the supply chains spread across many countries. Covid-19 pandemic highlighted that neglecting and ignoring the need for a global effort in vaccine manufacturing and delivery can have alarming, and devastating, repercussions, especially when the world needs a robust healthcare ecosystem to make sure that all of us are safe. So, the natural question is: what does the world need to be well-prepared for the next virus; what does it take to have the manufacturing of vaccines become less concentrated in a few countries and centers and diversified to more countries so that distribution can be more universal, so that all of us are safe? First will need to be the political recognition, and the acceptance, that no country can do or supply everything alone in the pharmaceutical sector — no country can be an island —and that binding international agreements will need to be adopted to make access to medicine more equitable and secure around the world. Furthermore, and critically so, significant long-term sustained investment in human resources must be adopted to fill major gaps in expertise, starting with a robust educational system whose graduates have the knowledge, ability, and capacity to work in this technical industry. Only then, with a professional-educated labor force, can resilient pharma-manufacturing clusters be successfully built throughout the world, which can, and will, give life to the new health code: “No one is safe, until everyone is safe.”

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制药:不被重视和忽视的不可或缺的技能。
疫苗的生产和制造过程耗时、复杂、昂贵且技术性强,需要拥有不同投入的多家公司之间的密切协调与合作,从活性药物成分到玻璃,再到专业化,供应链遍布许多国家。新冠肺炎大流行强调,忽视和忽视全球疫苗生产和交付努力的必要性可能会产生令人担忧和毁灭性的影响,尤其是当世界需要一个强大的医疗保健生态系统来确保我们所有人的安全时。因此,自然的问题是:世界需要为下一种病毒做好什么准备;如何才能使疫苗的生产不那么集中在少数国家和中心,而向更多国家多样化,从而使分发更加普遍,从而使我们所有人都安全?首先需要在政治上承认和接受,没有哪个国家可以独自在制药部门做或供应一切——没有哪个国家是一个岛屿——需要通过具有约束力的国际协议,使世界各地获得药品的机会更加公平和安全。此外,至关重要的是,必须对人力资源进行重大的长期持续投资,以填补专业知识方面的重大缺口,首先要建立一个健全的教育体系,让毕业生具备在这一技术行业工作的知识、能力和能力。只有这样,有了受过专业教育的劳动力,才能在世界各地成功建立有韧性的制药制造集群,这能够也将赋予新的健康准则生命:“在每个人都安全之前,没有人是安全的。”
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
13.30
自引率
1.40%
发文量
94
审稿时长
67 days
期刊介绍: Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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