首页 > 最新文献

Current Opinion in Immunology最新文献

英文 中文
Vaccine policies in France and Europe 法国和欧洲的疫苗政策。
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102513
Alain Fischer , Patrick Peretti-Watel , Jeremy Ward
This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France.
本综述概述了法国 COVID-19 疫苗接种活动的成果,并评估了信息和强制手段在整个活动中各自发挥的作用。然后将这些数据与法国疫苗接种接受度的演变进行对比。
{"title":"Vaccine policies in France and Europe","authors":"Alain Fischer ,&nbsp;Patrick Peretti-Watel ,&nbsp;Jeremy Ward","doi":"10.1016/j.coi.2024.102513","DOIUrl":"10.1016/j.coi.2024.102513","url":null,"abstract":"<div><div>This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102513"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage barrier responses to oncogenic transformation
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.coi.2024.102524
J Magarian Blander
The well-documented protumorigenic roles of macrophages in advanced cancers can sometimes overshadow their beneficial functions in the earlier stages of tumor development. This essay explores the hypothesis that macrophages play a crucial protective role in premalignant tissues by sensing and responding to early oncogenic transformation. Their activity is closely intertwined with cell-intrinsic barriers to transformation — such as apoptosis, senescence, and DNA repair — which collectively work to suppress malignant progression. Thus, an integrated cell-intrinsic and macrophage response constitutes effective ‘oncogenic monitoring’. In premalignant tissues, macrophages interpret outputs of cell-intrinsic tumor suppression as oncogenic stress signals detected through innate immune sensors, initiating a protective, homeostatic response that mitigates potential progression to malignancy. By recontextualizing macrophage roles in the early immune landscape, it becomes evident that these cells can serve as key protectors, preventing or delaying tumor formation. Understanding this dual role of macrophages — protective in early tumorigenesis and protumorigenic in established cancers — offers new perspectives on harnessing their immune functions for cancer prevention and therapy.
{"title":"Macrophage barrier responses to oncogenic transformation","authors":"J Magarian Blander","doi":"10.1016/j.coi.2024.102524","DOIUrl":"10.1016/j.coi.2024.102524","url":null,"abstract":"<div><div>The well-documented protumorigenic roles of macrophages in advanced cancers can sometimes overshadow their beneficial functions in the earlier stages of tumor development. This essay explores the hypothesis that macrophages play a crucial protective role in premalignant tissues by sensing and responding to early oncogenic transformation. Their activity is closely intertwined with cell-intrinsic barriers to transformation — such as apoptosis, senescence, and DNA repair — which collectively work to suppress malignant progression. Thus, an integrated cell-intrinsic and macrophage response constitutes effective ‘oncogenic monitoring’. In premalignant tissues, macrophages interpret outputs of cell-intrinsic tumor suppression as oncogenic stress signals detected through innate immune sensors, initiating a protective, homeostatic response that mitigates potential progression to malignancy. By recontextualizing macrophage roles in the early immune landscape, it becomes evident that these cells can serve as key protectors, preventing or delaying tumor formation. Understanding this dual role of macrophages — protective in early tumorigenesis and protumorigenic in established cancers — offers new perspectives on harnessing their immune functions for cancer prevention and therapy.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102524"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional subsets of tumor-specific CD8+ T cells in draining lymph nodes and tumor microenvironment 引流淋巴结和肿瘤微环境中的肿瘤特异性 CD8+ T 细胞功能亚群
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2024-11-26 DOI: 10.1016/j.coi.2024.102506
Qizhao Huang , Lifan Xu , Lilin Ye
Accumulating evidence demonstrates that tumor-specific CD8+ T cells in tumor-draining lymph nodes (TdLNs) act as an upstream reservoir of exhausted subsets within tumor microenvironment (TME). This reservoir primarily consists of progenitor exhausted CD8+ T (TPEX) cells and newly defined tumor-specific memory subsets (TTSM). We propose that these two subsets work together to mediate the antitumor effects of PD-1/PD-L1 immune checkpoint blockade (ICB) in a spatiotemporal manner. Although PD-1/PD-L1 ICB monotherapy drives the proliferation and further differentiation of these subsets, it does not alter the programmed differentiation trajectory from TTSM cells to TPEX cells, ultimately leading to the development of terminally exhausted CD8+ T cells. This phenomenon may partly explaining the frequent relapse in patients following initial ICB therapy. In this review, we focus on the phenotypic and functional heterogeneity of tumor-specific CD8+ T cells in both TdLNs and the TME and discuss the implications of these studies for ICB. Our insights aim to illuminate new strategies for advancing tumor immunotherapies.
越来越多的证据表明,肿瘤引流淋巴结(TdLNs)中的肿瘤特异性 CD8+ T 细胞是肿瘤微环境(TME)中衰竭亚群的上游储库。这个储库主要由原代衰竭 CD8+ T(TPEX)细胞和新定义的肿瘤特异性记忆亚群(TTSM)组成。我们提出,这两个亚群以时空方式共同介导 PD-1/PD-L1 免疫检查点阻断(ICB)的抗肿瘤效应。虽然PD-1/PD-L1 ICB单药治疗能促进这些亚群的增殖和进一步分化,但它并不能改变从TTSM细胞到TPEX细胞的程序化分化轨迹,最终导致CD8+ T细胞的终末衰竭。这一现象可能部分解释了患者在接受初始 ICB 治疗后频繁复发的原因。在这篇综述中,我们重点探讨了 TdLN 和 TME 中肿瘤特异性 CD8+ T 细胞的表型和功能异质性,并讨论了这些研究对 ICB 的影响。我们的见解旨在阐明推进肿瘤免疫疗法的新策略。
{"title":"Functional subsets of tumor-specific CD8+ T cells in draining lymph nodes and tumor microenvironment","authors":"Qizhao Huang ,&nbsp;Lifan Xu ,&nbsp;Lilin Ye","doi":"10.1016/j.coi.2024.102506","DOIUrl":"10.1016/j.coi.2024.102506","url":null,"abstract":"<div><div>Accumulating evidence demonstrates that tumor-specific CD8<sup>+</sup> T cells in tumor-draining lymph nodes (TdLNs) act as an upstream reservoir of exhausted subsets within tumor microenvironment (TME). This reservoir primarily consists of progenitor exhausted CD8<sup>+</sup> T (T<sub>PEX</sub>) cells and newly defined tumor-specific memory subsets (T<sub>TSM</sub>). We propose that these two subsets work together to mediate the antitumor effects of PD-1/PD-L1 immune checkpoint blockade (ICB) in a spatiotemporal manner. Although PD-1/PD-L1 ICB monotherapy drives the proliferation and further differentiation of these subsets, it does not alter the programmed differentiation trajectory from T<sub>TSM</sub> cells to T<sub>PEX</sub> cells, ultimately leading to the development of terminally exhausted CD8<sup>+</sup> T cells. This phenomenon may partly explaining the frequent relapse in patients following initial ICB therapy. In this review, we focus on the phenotypic and functional heterogeneity of tumor-specific CD8<sup>+</sup> T cells in both TdLNs and the TME and discuss the implications of these studies for ICB. Our insights aim to illuminate new strategies for advancing tumor immunotherapies.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102506"},"PeriodicalIF":6.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the neuroimmune axis in the atopic march: mechanisms and implications 解码特应性进展中的神经免疫轴:机制与影响。
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2024-11-22 DOI: 10.1016/j.coi.2024.102507
Laura Brabenec , Surbhi Gupta , Tuany Eichwald , Moutih Rafei , Sebastien Talbot
The immune and nervous systems have co-evolved complex mechanisms to sense environmental dangers and orchestrate a concerted response to safeguard tissue and mobilize host defenses. This sophisticated interplay, marked by a shared repertoire of receptors and ligands, influences disease pathogenesis. Neuro-immune interactions in allergic diseases are pivotal for symptom development, from anaphylaxis to chronic conditions like asthma and atopic dermatitis. This review explores the neuro-immune interplay within the atopic march, emphasizing its role in host defense, inflammation resolution, and tissue repair. We delve into the multifaceted functions of nociceptors in orchestrating type 2 immune responses and the progression of allergic disorders, focusing on key regulators such as CGRP-RAMP1 and SP-MRGPRB2/A2. Additionally, we discuss the potential of nociceptor neuron-blocking drugs to target neuro-immunity, offering the possibility of reversing the progression of the atopic march. Altogether, we underscore the need for targeted interventions to disrupt the pathological processes and enhance therapeutic outcomes at various stages of the atopic march.
免疫系统和神经系统共同进化出了复杂的机制,能够感知环境危险,并协调作出一致的反应,以保护组织和调动宿主的防御能力。这种复杂的相互作用以共同的受体和配体为特征,影响着疾病的发病机制。从过敏性休克到哮喘和特应性皮炎等慢性疾病,过敏性疾病中的神经-免疫相互作用对症状的发展至关重要。这篇综述探讨了特应性进展过程中神经免疫的相互作用,强调了神经免疫在宿主防御、炎症消退和组织修复中的作用。我们深入探讨了痛觉感受器在协调 2 型免疫反应和过敏性疾病进展中的多方面功能,重点关注 CGRP-RAMP1 和 SP-MRGPRB2/A2 等关键调节因子。此外,我们还讨论了针对神经免疫的痛觉感受器神经元阻断药物的潜力,这为逆转特应性进展提供了可能。总之,我们强调有必要在特应性进展的各个阶段采取有针对性的干预措施,以破坏病理过程并提高治疗效果。
{"title":"Decoding the neuroimmune axis in the atopic march: mechanisms and implications","authors":"Laura Brabenec ,&nbsp;Surbhi Gupta ,&nbsp;Tuany Eichwald ,&nbsp;Moutih Rafei ,&nbsp;Sebastien Talbot","doi":"10.1016/j.coi.2024.102507","DOIUrl":"10.1016/j.coi.2024.102507","url":null,"abstract":"<div><div>The immune and nervous systems have co-evolved complex mechanisms to sense environmental dangers and orchestrate a concerted response to safeguard tissue and mobilize host defenses. This sophisticated interplay, marked by a shared repertoire of receptors and ligands, influences disease pathogenesis. Neuro-immune interactions in allergic diseases are pivotal for symptom development, from anaphylaxis to chronic conditions like asthma and atopic dermatitis. This review explores the neuro-immune interplay within the atopic march, emphasizing its role in host defense, inflammation resolution, and tissue repair. We delve into the multifaceted functions of nociceptors in orchestrating type 2 immune responses and the progression of allergic disorders, focusing on key regulators such as CGRP-RAMP1 and SP-MRGPRB2/A2. Additionally, we discuss the potential of nociceptor neuron-blocking drugs to target neuro-immunity, offering the possibility of reversing the progression of the atopic march. Altogether, we underscore the need for targeted interventions to disrupt the pathological processes and enhance therapeutic outcomes at various stages of the atopic march.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102507"},"PeriodicalIF":6.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and risk factors for perinatal allergic disease 围产期过敏性疾病的机制和风险因素。
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2024-11-19 DOI: 10.1016/j.coi.2024.102505
Jozef Balla , Abhay PS Rathore , Ashley L St. John
Allergies are among the top causes of chronic disease in children. Their pathogenesis classically involves T helper 2 (Th2)-type inflammation driven by IgE-mediated allergen sensing. Triggers influencing allergic disease occur early in life, including before birth. The immature fetal immune system and mucosal barriers undergo periods of plasticity that are open to longitudinal programming by maternal influence. Evidence supports the importance of the maternal immune system in shaping perinatal immunity, as the transfer of cytokines, antibodies, and cells promotes offspring protection from pathogens. However, the same components may lead to allergic predisposition. Maternal–fetal interactions are further modified by epigenetic, metabolic, dietary, and microbiome-mediated effects. Here, we review how diverse maternal exposures and mediators signal across the placenta and through nursing perinatally to promote future tolerance or enhance reactivity against allergens. Improved understanding of the mechanisms predisposing for allergic disease in early life can guide the development of new therapeutics and preventative lifestyle modifications.
过敏是导致儿童慢性疾病的主要原因之一。其发病机理通常涉及由 IgE 介导的过敏原感应驱动的 T 辅助细胞 2(Th2)型炎症。影响过敏性疾病的诱因发生在生命早期,包括出生前。未成熟的胎儿免疫系统和粘膜屏障会经历一段可塑性时期,并受母体影响的纵向编程。有证据表明,母体免疫系统在塑造围产期免疫力方面具有重要作用,因为细胞因子、抗体和细胞的转移可促进后代免受病原体的侵害。然而,同样的成分也可能导致过敏倾向。表观遗传、新陈代谢、饮食和微生物介导的影响进一步改变了母胎之间的相互作用。在此,我们回顾了不同的母体暴露和介质如何通过胎盘和围产期哺乳发出信号,以促进未来的耐受性或增强对过敏原的反应性。提高对生命早期过敏性疾病易感性机制的认识,可以指导新疗法的开发和预防性生活方式的调整。
{"title":"Mechanisms and risk factors for perinatal allergic disease","authors":"Jozef Balla ,&nbsp;Abhay PS Rathore ,&nbsp;Ashley L St. John","doi":"10.1016/j.coi.2024.102505","DOIUrl":"10.1016/j.coi.2024.102505","url":null,"abstract":"<div><div>Allergies are among the top causes of chronic disease in children. Their pathogenesis classically involves T helper 2 (Th2)-type inflammation driven by IgE-mediated allergen sensing. Triggers influencing allergic disease occur early in life, including before birth. The immature fetal immune system and mucosal barriers undergo periods of plasticity that are open to longitudinal programming by maternal influence. Evidence supports the importance of the maternal immune system in shaping perinatal immunity, as the transfer of cytokines, antibodies, and cells promotes offspring protection from pathogens. However, the same components may lead to allergic predisposition. Maternal–fetal interactions are further modified by epigenetic, metabolic, dietary, and microbiome-mediated effects. Here, we review how diverse maternal exposures and mediators signal across the placenta and through nursing perinatally to promote future tolerance or enhance reactivity against allergens. Improved understanding of the mechanisms predisposing for allergic disease in early life can guide the development of new therapeutics and preventative lifestyle modifications.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102505"},"PeriodicalIF":6.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B cells spatial organization defines their phenotype and function in cancer “Tell me with whom you consort, and I will tell you who you are” ― Goethe B 细胞的空间组织决定了它们在癌症中的表型和功能 "告诉我你与谁为伍,我就告诉你你是谁"--歌德。
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2024-11-14 DOI: 10.1016/j.coi.2024.102504
Lloyd Bod , Shabnam Shalapour
The presence of B cells and their subtypes in the tumor environment has been recognized a for very long time. Immunoglobulins specific for more than thousands of tumor-associated antigens were detected in the sera of patients with cancer; however, antibody-mediated cancer cell killing is usually impaired. The role of humoral immune response remained elusive until recently, with new discoveries regarding their contribution in regulating antitumor immunity, particularly during immunotherapy. Humoral immunity has been described to promote or attenuate tumorigenesis and can have opposing effects on therapeutic outcome in different tumor entities. The antagonism effect of B cells depends on their subtypes and immunoglobulin isotypes and is regulated by their spatial distribution and localization. In this short review, we will focus on how the spatial organization of B cells within the tumor microenvironment, tumor-associated lymph nodes, and tertiary lymphoid structures define their fate and function and contribute to the regulation of antitumor immunity.
人们认识到肿瘤环境中存在 B 细胞及其亚型已有很长时间。在癌症患者的血清中检测到了针对数千种肿瘤相关抗原的特异性免疫球蛋白;然而,抗体介导的癌细胞杀伤通常会受到损害。直到最近,人们才发现体液免疫反应在调节抗肿瘤免疫中的作用,尤其是在免疫治疗期间。据描述,体液免疫可促进或减弱肿瘤发生,并对不同肿瘤实体的治疗效果产生相反的影响。B 细胞的拮抗作用取决于其亚型和免疫球蛋白异型,并受其空间分布和定位的调节。在这篇简短的综述中,我们将重点讨论 B 细胞在肿瘤微环境、肿瘤相关淋巴结和三级淋巴结构中的空间组织如何决定其命运和功能,以及如何促进抗肿瘤免疫的调节。
{"title":"B cells spatial organization defines their phenotype and function in cancer “Tell me with whom you consort, and I will tell you who you are” ― Goethe","authors":"Lloyd Bod ,&nbsp;Shabnam Shalapour","doi":"10.1016/j.coi.2024.102504","DOIUrl":"10.1016/j.coi.2024.102504","url":null,"abstract":"<div><div>The presence of B cells and their subtypes in the tumor environment has been recognized a for very long time. Immunoglobulins specific for more than thousands of tumor-associated antigens were detected in the sera of patients with cancer; however, antibody-mediated cancer cell killing is usually impaired. The role of humoral immune response remained elusive until recently, with new discoveries regarding their contribution in regulating antitumor immunity, particularly during immunotherapy. Humoral immunity has been described to promote or attenuate tumorigenesis and can have opposing effects on therapeutic outcome in different tumor entities. The antagonism effect of B cells depends on their subtypes and immunoglobulin isotypes and is regulated by their spatial distribution and localization. In this short review, we will focus on how the spatial organization of B cells within the tumor microenvironment, tumor-associated lymph nodes, and tertiary lymphoid structures define their fate and function and contribute to the regulation of antitumor immunity.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102504"},"PeriodicalIF":6.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovering mechanisms of macrophage tissue infiltration with Drosophila 用果蝇探索巨噬细胞组织浸润的机制
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2024-11-12 DOI: 10.1016/j.coi.2024.102502
Daria E Siekhaus , Jasmine A Stanley-Ahmed
Much is known about the importance of macrophages for regulating diverse aspects of organismal physiology, alongside their essential roles in inflammation. Relatively unexplored are the processes influencing macrophages’ and monocytes’ ability to invade into the tissues where they carry out these functions. Drosophila plasmatocytes, also called hemocytes, show similarities to vertebrate macrophages in their function and their molecular specification; they have recently been shown to also infiltrate into tissues during development and inflammation. Extravasation across vasculature, into tumors, the brain, and adipose tissue have all been observed. We discuss the striking parallels in some of these systems to vertebrate immune responses, including a requirement for tumor necrosis factor. Finally, we highlight the new pathways regulating infiltration found in the fly that remain as yet unexamined in a vertebrate context.
除了在炎症中的重要作用外,人们对巨噬细胞在调节机体生理各方面的重要性也有很多了解。相对而言,影响巨噬细胞和单核细胞侵入其执行这些功能的组织的能力的过程尚未被探索。果蝇的浆细胞(又称血细胞)在功能和分子规格上与脊椎动物的巨噬细胞相似;最近的研究表明,它们也会在发育和炎症过程中渗入组织。在血管、肿瘤、大脑和脂肪组织中都观察到了外渗现象。我们讨论了其中一些系统与脊椎动物免疫反应的惊人相似之处,包括对肿瘤坏死因子的需求。最后,我们强调了在蝇类中发现的调节浸润的新途径,这些途径在脊椎动物中仍未得到研究。
{"title":"Discovering mechanisms of macrophage tissue infiltration with Drosophila","authors":"Daria E Siekhaus ,&nbsp;Jasmine A Stanley-Ahmed","doi":"10.1016/j.coi.2024.102502","DOIUrl":"10.1016/j.coi.2024.102502","url":null,"abstract":"<div><div>Much is known about the importance of macrophages for regulating diverse aspects of organismal physiology, alongside their essential roles in inflammation. Relatively unexplored are the processes influencing macrophages’ and monocytes’ ability to invade into the tissues where they carry out these functions. <em>Drosophila</em> plasmatocytes, also called hemocytes, show similarities to vertebrate macrophages in their function and their molecular specification; they have recently been shown to also infiltrate into tissues during development and inflammation. Extravasation across vasculature, into tumors, the brain, and adipose tissue have all been observed. We discuss the striking parallels in some of these systems to vertebrate immune responses, including a requirement for tumor necrosis factor. Finally, we highlight the new pathways regulating infiltration found in the fly that remain as yet unexamined in a vertebrate context.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102502"},"PeriodicalIF":6.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial-immune interactions govern type 2 immunity at barrier surfaces 上皮细胞与免疫系统之间的相互作用制约着屏障表面的 2 型免疫。
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2024-11-10 DOI: 10.1016/j.coi.2024.102501
Alejandra Lopez Espinoza , Tighe Christopher , Elia D Tait Wojno
Allergic diseases are acute and chronic inflammatory conditions resulting from disproportionate responses to environmental stimuli. Affecting approximately 40% of the global population, these diseases significantly contribute to morbidity and increasing health care costs. Allergic reactions are triggered by pollen, house dust mites, animal dander, mold, food antigens, venoms, toxins, and drugs. This review explores the pivotal role of the epithelium in the skin, lungs, and gastrointestinal tract in regulating the allergic response and delves into the mechanisms of tissue-specific epithelial–immune interactions in this context, with recent advances highlighting their roles in the initiation, elicitation, and resolution phases of allergy. Understanding these intricate interactions at epithelial barriers is essential for developing targeted therapies to manage and treat allergic diseases.
过敏性疾病是由于对环境刺激的过度反应而导致的急性和慢性炎症。全球约有 40% 的人患有过敏性疾病,这些疾病大大增加了发病率和医疗成本。引发过敏反应的因素包括花粉、屋尘螨、动物皮屑、霉菌、食物抗原、毒物、毒素和药物。这篇综述探讨了皮肤、肺部和胃肠道上皮细胞在调节过敏反应中的关键作用,并深入研究了在此背景下组织特异性上皮细胞与免疫相互作用的机制,其最新进展突显了它们在过敏的引发、诱发和缓解阶段的作用。了解上皮屏障上这些错综复杂的相互作用对于开发控制和治疗过敏性疾病的靶向疗法至关重要。
{"title":"Epithelial-immune interactions govern type 2 immunity at barrier surfaces","authors":"Alejandra Lopez Espinoza ,&nbsp;Tighe Christopher ,&nbsp;Elia D Tait Wojno","doi":"10.1016/j.coi.2024.102501","DOIUrl":"10.1016/j.coi.2024.102501","url":null,"abstract":"<div><div>Allergic diseases are acute and chronic inflammatory conditions resulting from disproportionate responses to environmental stimuli. Affecting approximately 40% of the global population, these diseases significantly contribute to morbidity and increasing health care costs. Allergic reactions are triggered by pollen, house dust mites, animal dander, mold, food antigens, venoms, toxins, and drugs. This review explores the pivotal role of the epithelium in the skin, lungs, and gastrointestinal tract in regulating the allergic response and delves into the mechanisms of tissue-specific epithelial–immune interactions in this context, with recent advances highlighting their roles in the initiation, elicitation, and resolution phases of allergy. Understanding these intricate interactions at epithelial barriers is essential for developing targeted therapies to manage and treat allergic diseases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102501"},"PeriodicalIF":6.6,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic adaptations of ILC2 and Th2 cells in type 2 immunity 2 型免疫中 ILC2 和 Th2 细胞的代谢适应性。
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2024-11-08 DOI: 10.1016/j.coi.2024.102503
Anna K Kania , Efthymia Kokkinou , Erika Pearce, Edward Pearce
Type 2 immune responses play a crucial role in host defense against parasitic infections but can also promote the development of allergies and asthma. This response is orchestrated primarily by group 2 innate lymphoid cells (ILC2) and helper type 2 (Th2) cells, both of which undergo substantial metabolic reprogramming as they transition from resting to activated states. Understanding these metabolic adaptations not only provides insights into the fundamental biology of ILC2 and Th2 cells but also opens up potential therapeutic avenues for the identification of novel metabolic targets that can extend the current treatment regimens for diseases in which type 2 immune responses play pivotal roles. By integrating recent findings, this review underscores the significance of cellular metabolism in orchestrating immune functions and highlights future directions for research in this evolving field.
2型免疫反应在宿主抵御寄生虫感染的过程中起着至关重要的作用,但也会促进过敏和哮喘的发生。这种反应主要由第 2 组先天性淋巴细胞(ILC2)和辅助性 2 型细胞(Th2)协调,这两种细胞在从静息状态过渡到活化状态时都要进行大量的新陈代谢重编程。了解这些新陈代谢适应性不仅能深入了解 ILC2 和 Th2 细胞的基本生物学特性,还能为确定新的代谢靶点开辟潜在的治疗途径,从而扩展目前治疗 2 型免疫反应起关键作用的疾病的方案。通过整合最新研究成果,本综述强调了细胞代谢在协调免疫功能方面的重要性,并突出了这一不断发展的领域未来的研究方向。
{"title":"Metabolic adaptations of ILC2 and Th2 cells in type 2 immunity","authors":"Anna K Kania ,&nbsp;Efthymia Kokkinou ,&nbsp;Erika Pearce,&nbsp;Edward Pearce","doi":"10.1016/j.coi.2024.102503","DOIUrl":"10.1016/j.coi.2024.102503","url":null,"abstract":"<div><div>Type 2 immune responses play a crucial role in host defense against parasitic infections but can also promote the development of allergies and asthma. This response is orchestrated primarily by group 2 innate lymphoid cells (ILC2) and helper type 2 (Th2) cells, both of which undergo substantial metabolic reprogramming as they transition from resting to activated states. Understanding these metabolic adaptations not only provides insights into the fundamental biology of ILC2 and Th2 cells but also opens up potential therapeutic avenues for the identification of novel metabolic targets that can extend the current treatment regimens for diseases in which type 2 immune responses play pivotal roles. By integrating recent findings, this review underscores the significance of cellular metabolism in orchestrating immune functions and highlights future directions for research in this evolving field.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102503"},"PeriodicalIF":6.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue-resident memory cells in antitumoral immunity and cancer immunotherapy 抗肿瘤免疫和癌症免疫疗法中的组织驻留记忆细胞
IF 6.6 2区 医学 Q1 IMMUNOLOGY Pub Date : 2024-10-31 DOI: 10.1016/j.coi.2024.102499
Daniel Min , Jacob Fiedler , Niroshana Anandasabapathy
As cancer immunotherapy evolves, tissue-resident memory (TRM) cells remain key contributors to the antitumoral immune response due to their ability to mediate local tumor control, high expression of immune checkpoints, potential to respond to immunotherapy, and location across tissue sites where distal tumor metastases occur. This review synthesizes recent findings on the biology of TRM cells, their role in cancer, and their interactions with the tumor microenvironment. We also identify several critical research gaps, such as how mechanistic interrogation of TRM cell function is required for integration into therapeutics, proposing a focused research agenda to better exploit their potential.
随着癌症免疫疗法的发展,组织驻留记忆(TRM)细胞仍然是抗肿瘤免疫反应的关键因素,因为它们能够介导局部肿瘤控制、高表达免疫检查点、具有对免疫疗法产生反应的潜能以及位于发生远端肿瘤转移的组织部位。本综述综述了有关 TRM 细胞生物学、其在癌症中的作用及其与肿瘤微环境相互作用的最新研究成果。我们还指出了几个关键的研究空白点,例如如何从机理上分析 TRM 细胞的功能才能将其整合到疗法中,并提出了一个重点研究议程,以更好地开发它们的潜力。
{"title":"Tissue-resident memory cells in antitumoral immunity and cancer immunotherapy","authors":"Daniel Min ,&nbsp;Jacob Fiedler ,&nbsp;Niroshana Anandasabapathy","doi":"10.1016/j.coi.2024.102499","DOIUrl":"10.1016/j.coi.2024.102499","url":null,"abstract":"<div><div>As cancer immunotherapy evolves, tissue-resident memory (T<sub>RM</sub>) cells remain key contributors to the antitumoral immune response due to their ability to mediate local tumor control, high expression of immune checkpoints, potential to respond to immunotherapy, and location across tissue sites where distal tumor metastases occur. This review synthesizes recent findings on the biology of T<sub>RM</sub> cells, their role in cancer, and their interactions with the tumor microenvironment. We also identify several critical research gaps, such as how mechanistic interrogation of T<sub>RM</sub> cell function is required for integration into therapeutics, proposing a focused research agenda to better exploit their potential.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102499"},"PeriodicalIF":6.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Current Opinion in Immunology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1