Pub Date : 2025-02-01DOI: 10.1016/j.coi.2024.102513
Alain Fischer , Patrick Peretti-Watel , Jeremy Ward
This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France.
{"title":"Vaccine policies in France and Europe","authors":"Alain Fischer , Patrick Peretti-Watel , Jeremy Ward","doi":"10.1016/j.coi.2024.102513","DOIUrl":"10.1016/j.coi.2024.102513","url":null,"abstract":"<div><div>This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102513"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.coi.2024.102524
J Magarian Blander
The well-documented protumorigenic roles of macrophages in advanced cancers can sometimes overshadow their beneficial functions in the earlier stages of tumor development. This essay explores the hypothesis that macrophages play a crucial protective role in premalignant tissues by sensing and responding to early oncogenic transformation. Their activity is closely intertwined with cell-intrinsic barriers to transformation — such as apoptosis, senescence, and DNA repair — which collectively work to suppress malignant progression. Thus, an integrated cell-intrinsic and macrophage response constitutes effective ‘oncogenic monitoring’. In premalignant tissues, macrophages interpret outputs of cell-intrinsic tumor suppression as oncogenic stress signals detected through innate immune sensors, initiating a protective, homeostatic response that mitigates potential progression to malignancy. By recontextualizing macrophage roles in the early immune landscape, it becomes evident that these cells can serve as key protectors, preventing or delaying tumor formation. Understanding this dual role of macrophages — protective in early tumorigenesis and protumorigenic in established cancers — offers new perspectives on harnessing their immune functions for cancer prevention and therapy.
{"title":"Macrophage barrier responses to oncogenic transformation","authors":"J Magarian Blander","doi":"10.1016/j.coi.2024.102524","DOIUrl":"10.1016/j.coi.2024.102524","url":null,"abstract":"<div><div>The well-documented protumorigenic roles of macrophages in advanced cancers can sometimes overshadow their beneficial functions in the earlier stages of tumor development. This essay explores the hypothesis that macrophages play a crucial protective role in premalignant tissues by sensing and responding to early oncogenic transformation. Their activity is closely intertwined with cell-intrinsic barriers to transformation — such as apoptosis, senescence, and DNA repair — which collectively work to suppress malignant progression. Thus, an integrated cell-intrinsic and macrophage response constitutes effective ‘oncogenic monitoring’. In premalignant tissues, macrophages interpret outputs of cell-intrinsic tumor suppression as oncogenic stress signals detected through innate immune sensors, initiating a protective, homeostatic response that mitigates potential progression to malignancy. By recontextualizing macrophage roles in the early immune landscape, it becomes evident that these cells can serve as key protectors, preventing or delaying tumor formation. Understanding this dual role of macrophages — protective in early tumorigenesis and protumorigenic in established cancers — offers new perspectives on harnessing their immune functions for cancer prevention and therapy.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102524"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-26DOI: 10.1016/j.coi.2024.102506
Qizhao Huang , Lifan Xu , Lilin Ye
Accumulating evidence demonstrates that tumor-specific CD8+ T cells in tumor-draining lymph nodes (TdLNs) act as an upstream reservoir of exhausted subsets within tumor microenvironment (TME). This reservoir primarily consists of progenitor exhausted CD8+ T (TPEX) cells and newly defined tumor-specific memory subsets (TTSM). We propose that these two subsets work together to mediate the antitumor effects of PD-1/PD-L1 immune checkpoint blockade (ICB) in a spatiotemporal manner. Although PD-1/PD-L1 ICB monotherapy drives the proliferation and further differentiation of these subsets, it does not alter the programmed differentiation trajectory from TTSM cells to TPEX cells, ultimately leading to the development of terminally exhausted CD8+ T cells. This phenomenon may partly explaining the frequent relapse in patients following initial ICB therapy. In this review, we focus on the phenotypic and functional heterogeneity of tumor-specific CD8+ T cells in both TdLNs and the TME and discuss the implications of these studies for ICB. Our insights aim to illuminate new strategies for advancing tumor immunotherapies.
{"title":"Functional subsets of tumor-specific CD8+ T cells in draining lymph nodes and tumor microenvironment","authors":"Qizhao Huang , Lifan Xu , Lilin Ye","doi":"10.1016/j.coi.2024.102506","DOIUrl":"10.1016/j.coi.2024.102506","url":null,"abstract":"<div><div>Accumulating evidence demonstrates that tumor-specific CD8<sup>+</sup> T cells in tumor-draining lymph nodes (TdLNs) act as an upstream reservoir of exhausted subsets within tumor microenvironment (TME). This reservoir primarily consists of progenitor exhausted CD8<sup>+</sup> T (T<sub>PEX</sub>) cells and newly defined tumor-specific memory subsets (T<sub>TSM</sub>). We propose that these two subsets work together to mediate the antitumor effects of PD-1/PD-L1 immune checkpoint blockade (ICB) in a spatiotemporal manner. Although PD-1/PD-L1 ICB monotherapy drives the proliferation and further differentiation of these subsets, it does not alter the programmed differentiation trajectory from T<sub>TSM</sub> cells to T<sub>PEX</sub> cells, ultimately leading to the development of terminally exhausted CD8<sup>+</sup> T cells. This phenomenon may partly explaining the frequent relapse in patients following initial ICB therapy. In this review, we focus on the phenotypic and functional heterogeneity of tumor-specific CD8<sup>+</sup> T cells in both TdLNs and the TME and discuss the implications of these studies for ICB. Our insights aim to illuminate new strategies for advancing tumor immunotherapies.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"92 ","pages":"Article 102506"},"PeriodicalIF":6.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The immune and nervous systems have co-evolved complex mechanisms to sense environmental dangers and orchestrate a concerted response to safeguard tissue and mobilize host defenses. This sophisticated interplay, marked by a shared repertoire of receptors and ligands, influences disease pathogenesis. Neuro-immune interactions in allergic diseases are pivotal for symptom development, from anaphylaxis to chronic conditions like asthma and atopic dermatitis. This review explores the neuro-immune interplay within the atopic march, emphasizing its role in host defense, inflammation resolution, and tissue repair. We delve into the multifaceted functions of nociceptors in orchestrating type 2 immune responses and the progression of allergic disorders, focusing on key regulators such as CGRP-RAMP1 and SP-MRGPRB2/A2. Additionally, we discuss the potential of nociceptor neuron-blocking drugs to target neuro-immunity, offering the possibility of reversing the progression of the atopic march. Altogether, we underscore the need for targeted interventions to disrupt the pathological processes and enhance therapeutic outcomes at various stages of the atopic march.
{"title":"Decoding the neuroimmune axis in the atopic march: mechanisms and implications","authors":"Laura Brabenec , Surbhi Gupta , Tuany Eichwald , Moutih Rafei , Sebastien Talbot","doi":"10.1016/j.coi.2024.102507","DOIUrl":"10.1016/j.coi.2024.102507","url":null,"abstract":"<div><div>The immune and nervous systems have co-evolved complex mechanisms to sense environmental dangers and orchestrate a concerted response to safeguard tissue and mobilize host defenses. This sophisticated interplay, marked by a shared repertoire of receptors and ligands, influences disease pathogenesis. Neuro-immune interactions in allergic diseases are pivotal for symptom development, from anaphylaxis to chronic conditions like asthma and atopic dermatitis. This review explores the neuro-immune interplay within the atopic march, emphasizing its role in host defense, inflammation resolution, and tissue repair. We delve into the multifaceted functions of nociceptors in orchestrating type 2 immune responses and the progression of allergic disorders, focusing on key regulators such as CGRP-RAMP1 and SP-MRGPRB2/A2. Additionally, we discuss the potential of nociceptor neuron-blocking drugs to target neuro-immunity, offering the possibility of reversing the progression of the atopic march. Altogether, we underscore the need for targeted interventions to disrupt the pathological processes and enhance therapeutic outcomes at various stages of the atopic march.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102507"},"PeriodicalIF":6.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-19DOI: 10.1016/j.coi.2024.102505
Jozef Balla , Abhay PS Rathore , Ashley L St. John
Allergies are among the top causes of chronic disease in children. Their pathogenesis classically involves T helper 2 (Th2)-type inflammation driven by IgE-mediated allergen sensing. Triggers influencing allergic disease occur early in life, including before birth. The immature fetal immune system and mucosal barriers undergo periods of plasticity that are open to longitudinal programming by maternal influence. Evidence supports the importance of the maternal immune system in shaping perinatal immunity, as the transfer of cytokines, antibodies, and cells promotes offspring protection from pathogens. However, the same components may lead to allergic predisposition. Maternal–fetal interactions are further modified by epigenetic, metabolic, dietary, and microbiome-mediated effects. Here, we review how diverse maternal exposures and mediators signal across the placenta and through nursing perinatally to promote future tolerance or enhance reactivity against allergens. Improved understanding of the mechanisms predisposing for allergic disease in early life can guide the development of new therapeutics and preventative lifestyle modifications.
过敏是导致儿童慢性疾病的主要原因之一。其发病机理通常涉及由 IgE 介导的过敏原感应驱动的 T 辅助细胞 2(Th2)型炎症。影响过敏性疾病的诱因发生在生命早期,包括出生前。未成熟的胎儿免疫系统和粘膜屏障会经历一段可塑性时期,并受母体影响的纵向编程。有证据表明,母体免疫系统在塑造围产期免疫力方面具有重要作用,因为细胞因子、抗体和细胞的转移可促进后代免受病原体的侵害。然而,同样的成分也可能导致过敏倾向。表观遗传、新陈代谢、饮食和微生物介导的影响进一步改变了母胎之间的相互作用。在此,我们回顾了不同的母体暴露和介质如何通过胎盘和围产期哺乳发出信号,以促进未来的耐受性或增强对过敏原的反应性。提高对生命早期过敏性疾病易感性机制的认识,可以指导新疗法的开发和预防性生活方式的调整。
{"title":"Mechanisms and risk factors for perinatal allergic disease","authors":"Jozef Balla , Abhay PS Rathore , Ashley L St. John","doi":"10.1016/j.coi.2024.102505","DOIUrl":"10.1016/j.coi.2024.102505","url":null,"abstract":"<div><div>Allergies are among the top causes of chronic disease in children. Their pathogenesis classically involves T helper 2 (Th2)-type inflammation driven by IgE-mediated allergen sensing. Triggers influencing allergic disease occur early in life, including before birth. The immature fetal immune system and mucosal barriers undergo periods of plasticity that are open to longitudinal programming by maternal influence. Evidence supports the importance of the maternal immune system in shaping perinatal immunity, as the transfer of cytokines, antibodies, and cells promotes offspring protection from pathogens. However, the same components may lead to allergic predisposition. Maternal–fetal interactions are further modified by epigenetic, metabolic, dietary, and microbiome-mediated effects. Here, we review how diverse maternal exposures and mediators signal across the placenta and through nursing perinatally to promote future tolerance or enhance reactivity against allergens. Improved understanding of the mechanisms predisposing for allergic disease in early life can guide the development of new therapeutics and preventative lifestyle modifications.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102505"},"PeriodicalIF":6.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-14DOI: 10.1016/j.coi.2024.102504
Lloyd Bod , Shabnam Shalapour
The presence of B cells and their subtypes in the tumor environment has been recognized a for very long time. Immunoglobulins specific for more than thousands of tumor-associated antigens were detected in the sera of patients with cancer; however, antibody-mediated cancer cell killing is usually impaired. The role of humoral immune response remained elusive until recently, with new discoveries regarding their contribution in regulating antitumor immunity, particularly during immunotherapy. Humoral immunity has been described to promote or attenuate tumorigenesis and can have opposing effects on therapeutic outcome in different tumor entities. The antagonism effect of B cells depends on their subtypes and immunoglobulin isotypes and is regulated by their spatial distribution and localization. In this short review, we will focus on how the spatial organization of B cells within the tumor microenvironment, tumor-associated lymph nodes, and tertiary lymphoid structures define their fate and function and contribute to the regulation of antitumor immunity.
人们认识到肿瘤环境中存在 B 细胞及其亚型已有很长时间。在癌症患者的血清中检测到了针对数千种肿瘤相关抗原的特异性免疫球蛋白;然而,抗体介导的癌细胞杀伤通常会受到损害。直到最近,人们才发现体液免疫反应在调节抗肿瘤免疫中的作用,尤其是在免疫治疗期间。据描述,体液免疫可促进或减弱肿瘤发生,并对不同肿瘤实体的治疗效果产生相反的影响。B 细胞的拮抗作用取决于其亚型和免疫球蛋白异型,并受其空间分布和定位的调节。在这篇简短的综述中,我们将重点讨论 B 细胞在肿瘤微环境、肿瘤相关淋巴结和三级淋巴结构中的空间组织如何决定其命运和功能,以及如何促进抗肿瘤免疫的调节。
{"title":"B cells spatial organization defines their phenotype and function in cancer “Tell me with whom you consort, and I will tell you who you are” ― Goethe","authors":"Lloyd Bod , Shabnam Shalapour","doi":"10.1016/j.coi.2024.102504","DOIUrl":"10.1016/j.coi.2024.102504","url":null,"abstract":"<div><div>The presence of B cells and their subtypes in the tumor environment has been recognized a for very long time. Immunoglobulins specific for more than thousands of tumor-associated antigens were detected in the sera of patients with cancer; however, antibody-mediated cancer cell killing is usually impaired. The role of humoral immune response remained elusive until recently, with new discoveries regarding their contribution in regulating antitumor immunity, particularly during immunotherapy. Humoral immunity has been described to promote or attenuate tumorigenesis and can have opposing effects on therapeutic outcome in different tumor entities. The antagonism effect of B cells depends on their subtypes and immunoglobulin isotypes and is regulated by their spatial distribution and localization. In this short review, we will focus on how the spatial organization of B cells within the tumor microenvironment, tumor-associated lymph nodes, and tertiary lymphoid structures define their fate and function and contribute to the regulation of antitumor immunity.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102504"},"PeriodicalIF":6.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.coi.2024.102502
Daria E Siekhaus , Jasmine A Stanley-Ahmed
Much is known about the importance of macrophages for regulating diverse aspects of organismal physiology, alongside their essential roles in inflammation. Relatively unexplored are the processes influencing macrophages’ and monocytes’ ability to invade into the tissues where they carry out these functions. Drosophila plasmatocytes, also called hemocytes, show similarities to vertebrate macrophages in their function and their molecular specification; they have recently been shown to also infiltrate into tissues during development and inflammation. Extravasation across vasculature, into tumors, the brain, and adipose tissue have all been observed. We discuss the striking parallels in some of these systems to vertebrate immune responses, including a requirement for tumor necrosis factor. Finally, we highlight the new pathways regulating infiltration found in the fly that remain as yet unexamined in a vertebrate context.
{"title":"Discovering mechanisms of macrophage tissue infiltration with Drosophila","authors":"Daria E Siekhaus , Jasmine A Stanley-Ahmed","doi":"10.1016/j.coi.2024.102502","DOIUrl":"10.1016/j.coi.2024.102502","url":null,"abstract":"<div><div>Much is known about the importance of macrophages for regulating diverse aspects of organismal physiology, alongside their essential roles in inflammation. Relatively unexplored are the processes influencing macrophages’ and monocytes’ ability to invade into the tissues where they carry out these functions. <em>Drosophila</em> plasmatocytes, also called hemocytes, show similarities to vertebrate macrophages in their function and their molecular specification; they have recently been shown to also infiltrate into tissues during development and inflammation. Extravasation across vasculature, into tumors, the brain, and adipose tissue have all been observed. We discuss the striking parallels in some of these systems to vertebrate immune responses, including a requirement for tumor necrosis factor. Finally, we highlight the new pathways regulating infiltration found in the fly that remain as yet unexamined in a vertebrate context.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102502"},"PeriodicalIF":6.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-10DOI: 10.1016/j.coi.2024.102501
Alejandra Lopez Espinoza , Tighe Christopher , Elia D Tait Wojno
Allergic diseases are acute and chronic inflammatory conditions resulting from disproportionate responses to environmental stimuli. Affecting approximately 40% of the global population, these diseases significantly contribute to morbidity and increasing health care costs. Allergic reactions are triggered by pollen, house dust mites, animal dander, mold, food antigens, venoms, toxins, and drugs. This review explores the pivotal role of the epithelium in the skin, lungs, and gastrointestinal tract in regulating the allergic response and delves into the mechanisms of tissue-specific epithelial–immune interactions in this context, with recent advances highlighting their roles in the initiation, elicitation, and resolution phases of allergy. Understanding these intricate interactions at epithelial barriers is essential for developing targeted therapies to manage and treat allergic diseases.
{"title":"Epithelial-immune interactions govern type 2 immunity at barrier surfaces","authors":"Alejandra Lopez Espinoza , Tighe Christopher , Elia D Tait Wojno","doi":"10.1016/j.coi.2024.102501","DOIUrl":"10.1016/j.coi.2024.102501","url":null,"abstract":"<div><div>Allergic diseases are acute and chronic inflammatory conditions resulting from disproportionate responses to environmental stimuli. Affecting approximately 40% of the global population, these diseases significantly contribute to morbidity and increasing health care costs. Allergic reactions are triggered by pollen, house dust mites, animal dander, mold, food antigens, venoms, toxins, and drugs. This review explores the pivotal role of the epithelium in the skin, lungs, and gastrointestinal tract in regulating the allergic response and delves into the mechanisms of tissue-specific epithelial–immune interactions in this context, with recent advances highlighting their roles in the initiation, elicitation, and resolution phases of allergy. Understanding these intricate interactions at epithelial barriers is essential for developing targeted therapies to manage and treat allergic diseases.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102501"},"PeriodicalIF":6.6,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-08DOI: 10.1016/j.coi.2024.102503
Anna K Kania , Efthymia Kokkinou , Erika Pearce, Edward Pearce
Type 2 immune responses play a crucial role in host defense against parasitic infections but can also promote the development of allergies and asthma. This response is orchestrated primarily by group 2 innate lymphoid cells (ILC2) and helper type 2 (Th2) cells, both of which undergo substantial metabolic reprogramming as they transition from resting to activated states. Understanding these metabolic adaptations not only provides insights into the fundamental biology of ILC2 and Th2 cells but also opens up potential therapeutic avenues for the identification of novel metabolic targets that can extend the current treatment regimens for diseases in which type 2 immune responses play pivotal roles. By integrating recent findings, this review underscores the significance of cellular metabolism in orchestrating immune functions and highlights future directions for research in this evolving field.
{"title":"Metabolic adaptations of ILC2 and Th2 cells in type 2 immunity","authors":"Anna K Kania , Efthymia Kokkinou , Erika Pearce, Edward Pearce","doi":"10.1016/j.coi.2024.102503","DOIUrl":"10.1016/j.coi.2024.102503","url":null,"abstract":"<div><div>Type 2 immune responses play a crucial role in host defense against parasitic infections but can also promote the development of allergies and asthma. This response is orchestrated primarily by group 2 innate lymphoid cells (ILC2) and helper type 2 (Th2) cells, both of which undergo substantial metabolic reprogramming as they transition from resting to activated states. Understanding these metabolic adaptations not only provides insights into the fundamental biology of ILC2 and Th2 cells but also opens up potential therapeutic avenues for the identification of novel metabolic targets that can extend the current treatment regimens for diseases in which type 2 immune responses play pivotal roles. By integrating recent findings, this review underscores the significance of cellular metabolism in orchestrating immune functions and highlights future directions for research in this evolving field.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102503"},"PeriodicalIF":6.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31DOI: 10.1016/j.coi.2024.102499
Daniel Min , Jacob Fiedler , Niroshana Anandasabapathy
As cancer immunotherapy evolves, tissue-resident memory (TRM) cells remain key contributors to the antitumoral immune response due to their ability to mediate local tumor control, high expression of immune checkpoints, potential to respond to immunotherapy, and location across tissue sites where distal tumor metastases occur. This review synthesizes recent findings on the biology of TRM cells, their role in cancer, and their interactions with the tumor microenvironment. We also identify several critical research gaps, such as how mechanistic interrogation of TRM cell function is required for integration into therapeutics, proposing a focused research agenda to better exploit their potential.
{"title":"Tissue-resident memory cells in antitumoral immunity and cancer immunotherapy","authors":"Daniel Min , Jacob Fiedler , Niroshana Anandasabapathy","doi":"10.1016/j.coi.2024.102499","DOIUrl":"10.1016/j.coi.2024.102499","url":null,"abstract":"<div><div>As cancer immunotherapy evolves, tissue-resident memory (T<sub>RM</sub>) cells remain key contributors to the antitumoral immune response due to their ability to mediate local tumor control, high expression of immune checkpoints, potential to respond to immunotherapy, and location across tissue sites where distal tumor metastases occur. This review synthesizes recent findings on the biology of T<sub>RM</sub> cells, their role in cancer, and their interactions with the tumor microenvironment. We also identify several critical research gaps, such as how mechanistic interrogation of T<sub>RM</sub> cell function is required for integration into therapeutics, proposing a focused research agenda to better exploit their potential.</div></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":"91 ","pages":"Article 102499"},"PeriodicalIF":6.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}