Gene-environment interactions that influence CVD, lipid traits, obesity, diabetes, and hypertension appear to be able to influence gene therapy

IF 8.7 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Aspects of Medicine Pub Date : 2023-09-11 DOI:10.1016/j.mam.2023.101213
Moataz Dowaidar
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Abstract

Most mind boggling diseases are accepted to be impacted by both genetic and environmental elements. As of late, there has been a flood in the improvement of different methodologies, concentrate on plans, and measurable and logical techniques to examine gene-environment cooperations (G × Es) in enormous scope studies including human populaces. The many-sided exchange between genetic elements and environmental openings has long charmed the consideration of clinicians and researchers looking to grasp the complicated starting points of diseases. While single variables can add to disease, the blend of genetic variations and environmental openings frequently decides disease risk. The fundamental point of this paper is to talk about the Gene-Environment Associations That Impact CVD, Lipid Characteristics, Obesity, Diabetes, and Hypertension Have all the earmarks of being Ready to Impact Gene Therapy. This survey paper investigates the meaning of gene-environment collaborations (G × E) in disease advancement. The intricacy of genetic and environmental communications in disease causation is explained, underlining the multifactorial idea of many circumstances. The job of gene-environment cooperations in cardiovascular disease, lipid digestion, diabetes, obesity, and hypertension is investigated. This audit fixates on Gene by Environment (G × E) collaborations, investigating their importance in disease etiology.

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影响CVD、脂质特征、肥胖、糖尿病和高血压的基因-环境相互作用似乎能够影响基因治疗
大多数令人难以置信的疾病都被认为受到遗传和环境因素的影响。最近,在包括人类普及在内的大规模研究中,人们大量改进不同的方法论、专注于计划以及可测量和逻辑的技术来检查基因-环境合作(G×Es)。遗传因素和环境开放之间的多方面交流长期以来一直吸引着临床医生和研究人员的考虑,他们希望掌握疾病的复杂起点。虽然单一变量会增加疾病,但基因变异和环境开放的结合往往决定了疾病的风险。本文的基本观点是讨论影响CVD、脂质特征、肥胖、糖尿病和高血压的基因环境关联,这些关联具有准备好影响基因治疗的所有特征。本文探讨了基因-环境协同(G×E)在疾病进展中的意义。解释了遗传和环境传播在疾病病因中的复杂性,强调了许多情况下的多因素思想。研究了基因环境协同作用在心血管疾病、脂质消化、糖尿病、肥胖症和高血压中的作用。本次审计专注于基因与环境(G×E)的合作,调查它们在疾病病因中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Aspects of Medicine
Molecular Aspects of Medicine 医学-生化与分子生物学
CiteScore
18.20
自引率
0.00%
发文量
85
审稿时长
55 days
期刊介绍: Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.
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