Short-term outcomes after selective shunt during carotid endarterectomy: a propensity score matching analysis

Juliana Pereira-Macedo , Luís Duarte-Gamas , António Pereira-Neves , José José Paulo de Andrade , João Rocha-Neves
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Abstract

Introduction and objectives

Carotid cross-clamping during carotid endarterectomy might lead to intraoperative neurologic deficits, increasing stroke/death risk. If deficits are detected, carotid shunting has been recommended to reduce the risk of stroke. However, shunting may sustain a specific chance of embolic events and subsequently incurring harm. Current evidence is still questionable regarding its clear benefit. The aim is to determine whether a policy of selective shunt impacts the complication rate following an endarterectomy.

Material and methods

From January 2013 to May 2021, all patients undergoing carotid endarterectomy under regional anesthesia with intraoperative neurologic alteration were retrieved. Patients submitted to selective shunt were compared to a non-shunt group. A 1:1 propensity score matching (PSM) was performed. Differences between the groups and clinical outcomes were calculated, resorting to univariate analysis.

Results

Ninety-eight patients were selected, from which 23 were operated on using a shunt. After PSM, 22 non-shunt patients were compared to 22 matched shunted patients. Concerning demographics and comorbidities, both groups were comparable to pre and post-PSM, except for chronic heart failure, which was more prevalent in shunted patients (26.1%, P = 0.036) in pre-PSM analysis. Regarding 30-day stroke and score Clavien–Dindo ≥2, no significant association was found (P = 0.730, P = 0.635 and P = 0.942, P = 0.472, correspondingly, for pre and post-PSM).

Conclusions

In this cohort, resorting to shunting did not demonstrate an advantage regarding 30-day stroke or a Clavien–Dindo ≥ 2 rates. Nevertheless, additional more extensive studies are mandatory to achieve precise results concerning the accurate utility of carotid shunting in this subset of patients under regional anesthesia.

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颈动脉内膜切除术选择性分流后的短期结果:倾向评分匹配分析。
引言和目的:颈动脉内膜切除术中颈动脉交叉夹闭可能导致术中神经功能缺损,增加中风/死亡风险。如果检测到缺陷,建议进行颈动脉分流以降低中风的风险。然而,分流可能会持续发生栓塞事件并随后造成伤害的特定机会。关于其明显的益处,目前的证据仍然值得怀疑。目的是确定选择性分流政策是否会影响动脉内膜切除术后的并发症发生率。材料和方法:从2013年1月至2021年5月,检索所有在区域麻醉下接受颈动脉内膜切除术并术中神经系统改变的患者。将接受选择性分流的患者与非分流组进行比较。进行1:1倾向评分匹配(PSM)。采用单因素分析法计算各组之间的差异和临床结果。结果:选择了98名患者,其中23人使用分流器进行了手术。PSM后,将22名非分流患者与22名匹配的分流患者进行比较。关于人口统计学和合并症,除了慢性心力衰竭外,这两组患者在PSM前分析中均与PSM前和PSM后相当,慢性心力衰竭在分流患者中更为普遍(26.1%,P=0.036)。关于30天卒中和Clavien-Dindo≥2的评分,没有发现显著的相关性(PSM前后分别为P=0.730,P=0.635和P=0.942,P=0.472)。然而,必须进行更多更广泛的研究,以获得关于颈动脉分流在该亚组区域麻醉患者中的准确应用的精确结果。
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