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Ganglioglioma mimicking a vestibular schwannoma: A rare entity of the cerebellopontine angle. 模拟前庭神经鞘瘤的神经节神经胶质瘤。少见的脑桥小脑角。
Pub Date : 2026-01-22 DOI: 10.1016/j.neucie.2026.500756
Marta Álvarez González, Javier Robla Costales, Adán González Álvarez, Guadalupe Iglesias Barrero

Gangliogliomas are rare tumors of the central nervous system, representing 1.3% of all brain tumors. Gangliogliomas of the cerebellopontine angle (CPA) are exceptional, and most of them are an exophytic extension of a primary brainstem or cerebellar tumor. We present the case of a 33-year-old man with histologically confirmed CPA ganglioglioma. The tumor was a nodular lesion attached to the 7th and 8th cranial nerves. The resection was complete and the diagnosis was possible only after histopathologic examination of the resected mass. It is necessary to keep in mind these unusual tumors in the differential diagnosis of CPA lesions.

神经节胶质瘤是一种罕见的中枢神经系统肿瘤,占所有脑肿瘤的1.3%。桥小脑角神经节胶质瘤是一种特殊的肿瘤,大多数是原发脑干或小脑肿瘤的外生性延伸。我们报告一例33岁男性,病理证实为CPA神经节胶质瘤。肿瘤为结节状病变,附着于第7和第8脑神经。切除是完整的,只有在切除的肿块进行组织病理学检查后才能诊断。在CPA病变的鉴别诊断中,有必要记住这些不寻常的肿瘤。
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引用次数: 0
Atypical non-enhancing brain metastases from ALK-positive non-small cell lung carcinoma. alk阳性非小细胞肺癌的非典型非强化脑转移。
Pub Date : 2026-01-22 DOI: 10.1016/j.neucie.2026.500758
Serdar Solmaz, Cafer Ikbal Gulsever

Brain metastases are a frequent complication of advanced non-small cell lung carcinoma (NSCLC), particularly in anaplastic lymphoma kinase (ALK)-positive cases, which show a strong tendency for central nervous system spread. Typically, such metastases demonstrate contrast enhancement on magnetic resonance imaging (MRI) due to disruption of the blood-brain barrier. We report a 45-year-old man with ALK-positive NSCLC presenting with a right temporal swelling and multiple non-contrast-enhancing brain lesions detected before any treatment. The temporal mass was excised and confirmed as metastatic adenocarcinoma. The patient received whole-brain radiotherapy (30Gy in 10 fractions), cisplatin-pemetrexed chemotherapy, and sequential targeted therapy with alectinib and lorlatinib. During three years of follow-up, MRI showed complete resolution of all lesions, and the patient remained neurologically intact and systemically stable. This case underscores the rarity of non-enhancing brain metastases in ALK-positive NSCLC and highlights the importance of recognizing this atypical imaging presentation for timely diagnosis and management.

脑转移是晚期非小细胞肺癌(NSCLC)的常见并发症,特别是间变性淋巴瘤激酶(ALK)阳性病例,其表现出强烈的中枢神经系统扩散趋势。通常,由于血脑屏障的破坏,这种转移在磁共振成像(MRI)上表现出对比增强。我们报告一例45岁的alk阳性非小细胞肺癌患者,在任何治疗前均表现为右侧颞叶肿胀和多发非增强脑损伤。切除颞骨肿块,确认为转移性腺癌。患者接受全脑放疗(10次30 Gy),顺铂-培美曲塞化疗,阿勒替尼、氯拉替尼序贯靶向治疗。在三年的随访中,MRI显示所有病变完全消退,患者神经系统完整,系统稳定。该病例强调了alk阳性NSCLC中非增强性脑转移的罕见性,并强调了识别这种非典型影像学表现对及时诊断和治疗的重要性。
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引用次数: 0
Diagnosis and surgical management of a pituitary adenoma coexisting with a persistent trigeminal artery: Case report and review of the literature. 垂体腺瘤并发持续性三叉动脉的诊断和手术治疗:病例报告和文献复习。
Pub Date : 2026-01-22 DOI: 10.1016/j.neucie.2026.500757
Loreto Esteban Estallo, Amanda Avedillo Ruidiaz, Silvia Vázquez Sufuentes, Miguel Barrera Rojas, David Fustero de Miguel

The persistent trigeminal artery (PTA) is the most frequent embryonic carotid-basilar anastomosis, with an incidence of 0.1-1%. Its coexistence with pituitary adenomas is extremely rare and may pose a significant surgical risk if unrecognized preoperatively. We describe a 58-year-old man incidentally diagnosed with a nonfunctioning pituitary macroadenoma compressing the optic chiasm. Computed tomography angiography demonstrated a PTA in close contact with the tumor's inferior aspect. Endoscopic endonasal resection was performed with neuronavigation and intraoperative Doppler ultrasound, enabling direct visualization and preservation of the artery. A small remnant firmly adherent to the vessel was intentionally left. This case highlights the importance of preoperative identification of vascular variants such as PTA. It also emphasizes the meticulous surgical planning to achieve safe pituitary tumor resection in the presence of high-risk vascular anomalies.

持续性三叉动脉(PTA)是最常见的胚胎颈动脉-基底动脉吻合,发生率为0.1%-1%。它与垂体腺瘤共存是极其罕见的,如果术前未被识别,可能会造成重大的手术风险。我们描述了一个58岁的男人偶然诊断为一个无功能的垂体大腺瘤压迫视交叉。计算机断层血管造影显示PTA与肿瘤的下侧面密切接触。内镜下鼻内切除术采用神经导航和术中多普勒超声,可以直接观察和保存动脉。故意留下一小块紧紧附着在容器上的残留物。这个病例强调了术前识别血管变异如PTA的重要性。同时强调了在存在高危血管异常的情况下,要做好周密的手术计划以实现垂体肿瘤的安全切除。
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引用次数: 0
Risk of haemorrhagic strokes in patients with psychiatric disorders: A systematic review and meta-analysis 精神疾病患者出血性中风的风险:系统回顾和荟萃分析
Pub Date : 2026-01-01 DOI: 10.1016/j.neucie.2025.500738
Luis Ayerbe , Quintí Foguet-Boreu , Ivo Forgnone , María Pérez-Piñar , Rohini Mathur , Salma Ayis

Objectives

Strong evidence on the risk of haemorrhagic strokes for those with psychiatric conditions may lead to more effective interventions for mental health patients and inform future studies. This systematic review aimed to identify all the studies that compare the risk of haemorrhagic stroke for patients with and without depression, anxiety, schizophrenia, bipolar or personality disorders. It also aimed to provide a summary estimate of the risk, where possible, using meta-analysis.

Methods

Electronic searches were conducted in Embase, PsycINFO, PubMED, Scopus and the Web of Science, from database inception to the 11th of March 2025. A Random-effects model to estimate the pooled effect size with 95% confidence intervals was used.

Results

17,214 references were initially identified. Eleven articles were included. Seven of them, five observational and two mendelian randomisation studies, investigated depression. In the meta-analysis depression showed a significant association with an increased risk of haemorrhagic stroke, with pooled HR: 1.28 (1.19–1.38) when only observational studies were included. When mendelian randomisation studies were added the result was a pooled HR: 1.26 (1.08–1.44). The risk of haemorrhagic stroke was increased in one of the three studies that investigated patients with anxiety disorders and in one of the three that looked at patients with schizophrenia. Two studies of bipolar disorder, and one of personality disorders, reported that patients with these conditions do not have an increased risk of haemorrhagic stroke.

Conclusion

Patients with depression have an increased risk of haemorrhagic stroke. The association of mental illness with haemorrhagic stroke needs further research.
目的:关于精神疾病患者出血性中风风险的有力证据可能导致对精神健康患者进行更有效的干预,并为未来的研究提供信息。本系统综述旨在确定所有比较患有和不患有抑郁症、焦虑症、精神分裂症、双相情感障碍或人格障碍患者出血性中风风险的研究。在可能的情况下,它还旨在使用荟萃分析提供风险的汇总估计。方法:在Embase、PsycINFO、PubMED、Scopus和Web of Science中检索自建库至2025年3月11日的文献。采用随机效应模型估计合并效应大小,置信区间为95%。结果:初步鉴定文献17214篇。纳入了11篇文章。其中7项研究,5项观察性研究和2项孟德尔随机研究,调查了抑郁症。在荟萃分析中,抑郁症与出血性卒中风险增加有显著关联,仅纳入观察性研究时,合并HR为1.28(1.19-1.38)。当加入孟德尔随机化研究时,合并风险比为1.26(1.08-1.44)。在调查焦虑症患者的三项研究中的一项和对精神分裂症患者的三项研究中的一项中,出血性中风的风险都有所增加。两项关于双相情感障碍的研究和一项关于人格障碍的研究报告称,患有这些疾病的患者发生出血性中风的风险并没有增加。结论:抑郁症患者发生出血性卒中的风险增加。精神疾病与出血性中风的关系需要进一步研究。
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引用次数: 0
Endoscopic 360° vision of the orbit: A comparative anatomical study of endonasal and transorbital approaches 内窥镜下眼眶360°视野:鼻内入路和眶内入路的比较解剖学研究。
Pub Date : 2026-01-01 DOI: 10.1016/j.neucie.2025.500704
Dario Gagliano , Roberto Manfrellotti , Nikolay Lasunin , Alberto Prats-Galino , Alberto Di Somma , Joaquim Enseñat

Background and objective

Treatment of lesions located within and surrounding the orbit pose considerable surgical challenges, due to the presence of critical neurovascular structures in such deep, confined spaces. Historically, transcranial and craniofacial approaches have been widely used to deal with orbital pathologies. However, in recent decades we have witnessed the emergence of minimally invasive techniques to reduce morbidity and hospitalization times. Among these techniques are the endoscopic endonasal approach (EEA) and the subsequently developed endoscopic transorbital approach (ETOA). This anatomical study aims to compare and combine the surgical view offered by these two endoscopic pathways to achieve a circumferential access to the orbit.

Methods

Anatomic dissections were performed at the Laboratory of Surgical NeuroAnatomy (LSNA) of the Human Anatomy and Embryology Unit, University of Barcelona (Barcelona, Spain) on five cadaveric specimens (10 sides), whose arterial and venous systems were injected with red and blue latex respectively. Dissections were made with microsurgical instruments and a surgical endoscope.

Results

After careful removal of the intraorbital fat, all the extraocular muscles were exposed and dissected, as well as the optic nerve, the ophthalmic artery, and the lacrimal gland. Special emphasis was given to dissecting the nerves’ course from the cavernous sinus to their muscle innervation: oculomotor and its branches, trochlear, abducent and ophthalmic nerve with its branches (frontal, nasociliary and lacrimal nerve). Each of the two endoscopic pathways provided a different perspective of the orbit and its structures. After both corridors were completed, a communication between the surgical pathways was highlighted, in a so-called connection area.

Conclusions

The combination of the EEA and ETOA provides a 360° view of the orbit and its contents. The EEA offers an inferior and medial view of the orbit, through the lamina papyracea of the ethmoid in the first case and through the roof of the maxillary sinus in the latter. At the same time, the ETOA shows a lateral perspective, removing the lateral rim of the orbit, allowing great maneuverability inside the orbit and a wide visualization. This study provides a detailed overview of the surgical neuroanatomy of the orbit, which is an essential and didactic baseline in preparation for practical clinical applications. Overall, EEA and ETOA seem adequate to gain optimal exposure of the orbit and can be adapted to treat a wide range of pathologies. Yet, surgical case series are necessary to establish the true clinical value of these endoscopic approaches in orbital and peri-orbital surgery. However, the limited number of specimens analyzed (5 cadavers, 10 sides) must be acknowledged as a limitation.
背景和目的:眶内及眶周病变的治疗带来了相当大的手术挑战,因为在如此深、狭窄的空间中存在关键的神经血管结构。历史上,经颅和颅面入路已被广泛用于治疗眼眶病变。然而,近几十年来,我们目睹了微创技术的出现,以减少发病率和住院时间。这些技术包括内窥镜鼻内入路(EEA)和随后发展的内窥镜经眶入路(ETOA)。本解剖研究的目的是比较和结合这两种内窥镜路径提供的手术视图,以实现眶周通道。方法:在西班牙巴塞罗那大学(Barcelona, Spain)人体解剖与胚胎科外科神经解剖实验室(LSNA)对5例(10侧)尸体标本进行解剖解剖,分别在动脉和静脉系统注射红色和蓝色乳胶。用显微手术器械和手术内窥镜进行解剖。结果:仔细去除眶内脂肪后,所有眼外肌以及视神经、眼动脉、泪腺均被暴露和剥离。特别强调了从海绵窦到其肌肉神经支配的神经路线:动眼神经及其分支,滑车,展神经和眼神经及其分支(额神经,鼻睫神经和泪神经)。两种内镜路径提供了眼眶及其结构的不同视角。在两条通道完成后,在所谓的连接区域中,突出了手术路径之间的通信。结论:EEA和ETOA的结合提供了360°的轨道及其内容视图。EEA提供眶的下内侧视图,在第一种情况下通过筛骨的纸莎草层,在第二种情况下通过上颌窦的顶部。同时,ETOA显示了一个横向视角,去掉了轨道的外侧边缘,允许轨道内部的大机动性和广泛的可视化。本研究提供了眼眶手术神经解剖学的详细概述,这是为实际临床应用做准备的必要和教学基线。总的来说,EEA和ETOA似乎足以获得最佳的眶位暴露,并且可以适应治疗各种病理。然而,外科病例系列是必要的,以确定这些内窥镜入路在眼眶和眶周手术中的真正临床价值。然而,必须承认分析的标本数量有限(5具尸体,10面)是一种限制。
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引用次数: 0
Measures to prevent surgical site infections in neurosurgery: Survey and comparative analysis 预防神经外科手术部位感染的措施:调查与比较分析。
Pub Date : 2026-01-01 DOI: 10.1016/j.neucie.2025.500678
Cristina Sánchez-Viguera , Josep M. Badia

Introduction

Surgical site infections (SSI) are among the most common type of healthcare-associated infections and are involved with an increase in morbidity, mortality and higher healthcare costs.

Methods

The Observatory of Infection in Surgery has conducted a survey to assess the level of awareness and implementation of the preventive measures for SSI. A 64-question questionnaire was given to SENEC (Sociedad Española de Neurocirugía) members.

Results

The survey was answered by 123 neurosurgeons. There is a gap between clinical guidelines and neurosurgery practice (67%), even though neurosurgeons place a high value on international (81.7%) or national (78.7%) clinical guidelines. There are still practices not supported by scientific evidence that some of our respondents follow, including antibiotic prophylaxis  24 h (10.6%), the habit of not allowing the antiseptic solution to air dry (38.2%) or the use of transparent plastic adhesive drape on the surgical field (77.4%). The most widespread practice for hair management is the selective removal from the surgical area (83.3%). It is most commonly performed by the neurosurgeon himself, in the operating room, which is a significant difference from the use of other surgical specialties (68.5% vs 3.5%, P < .001). There are only 37% of respondents who use alcohol solutions. Double-gloving is utilised by 16.7% of neurosurgeons. The usual use of drainage is quite widespread (60.7%), while the rate of nutritional assessment prior to major surgery is very low (7.5%). Only 37.2% report providing feedback on SSI rates to surgical teams, and a small 16.5% have received specific training programmes on SSI.

Conclusion

Scientific evidence-supported measures are not fully incorporated into neurosurgical practice, and there is a lack of specific training in surgical infection prevention. Additionally, a specific issue has been identified, particularly regarding hair management. Neurosurgeons should actively participate in SSI prevention programmes and analyse the reasons why they do not implement certain strategies into their clinical practice.
手术部位感染(SSI)是最常见的医疗保健相关感染类型之一,涉及发病率、死亡率增加和更高的医疗保健费用。方法:对外科感染观察站进行调查,评估手术感染预防措施的知晓程度和实施情况。向SENEC (Sociedad Española de Neurocirugía)成员发放了一份包含64个问题的问卷。结果:共有123名神经外科医生参与调查。临床指南和神经外科实践之间存在差距(67%),尽管神经外科医生高度重视国际(81.7%)或国家(78,7%)临床指南。我们的一些调查对象仍然遵循一些没有科学证据支持的做法,包括抗生素预防≥24小时(10.6%),不让抗菌溶液风干的习惯(38.2%)或在手术部位使用透明塑料粘合剂(77.4%)。最普遍的毛发管理做法是从手术区域选择性去除毛发(83.3%)。它最常由神经外科医生自己在手术室进行,这与其他外科专业的使用有显著差异(68.5% vs 3.5%, p< 0.001)。只有37%的受访者使用酒精溶液。16.7%的神经外科医生使用双手套。引流术的常规应用相当普遍(66.7%),而大手术前营养评估的比例非常低(7.5%)。只有37.2%的医生报告向外科团队提供了SSI率的反馈,只有16.5%的医生接受了SSI的具体培训计划。结论:科学的循证措施未完全纳入神经外科实践,缺乏外科感染预防的专门培训。此外,一个具体的问题已经确定,特别是关于头发管理。神经外科医生应积极参与SSI预防计划,并分析他们没有在临床实践中实施某些策略的原因。
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引用次数: 0
Patient perception and clinically meaningful change following simple cervical laminectomy for degenerative cervical myelopathy: A prospective cohort study 一项前瞻性队列研究:单纯颈椎板切除术治疗退行性颈椎病后患者感知和临床意义的改变。
Pub Date : 2026-01-01 DOI: 10.1016/j.neucie.2025.500735
Antonio Montalvo-Afonso , Vicente Martín-Velasco , Javier Martín-Alonso , Rubén Diana-Martín , Jerónimo González-Bernal , Pedro David Delgado-López
<div><h3>Introduction</h3><div>Validated clinical scales for cervical myelopathy (CM) assess disease severity and treatment efficacy, but often fail to capture the patient's subjective perception of treatment effects. This study aimed to correlate commonly used clinical scales for CM with patient-perceived outcomes after surgical treatment. Additionally, it sought to establish minimum clinically important difference (MCID) thresholds for scales strongly correlating with patient perception.</div></div><div><h3>Patients and methods</h3><div>A prospective, single-center observational study followed 47 patients with degenerative CM who underwent simple cervical laminectomy for one year. Patients were assessed using the mJOA, Nurick, cervical and brachial Visual Analogue Scales (VAS), the Neck Disability Index (NDI), and the EuroQol-5D (EQ5D). Patient perception of global effect (PGE) was assessed at 6 months and 1-year post-surgery using an anchor question asking if they perceived improvement, worsening, or no change. MCID was calculated using three anchor-based methods: mean difference, change difference, and the Youden Index from receiver operating characteristic (ROC) curves. Definitive MCID thresholds were the average of these three methods.</div></div><div><h3>Results</h3><div>At the end of the follow-up, 25 patients (53.2%) had perceived clinical improvement with surgery, 15 (31.9%) had perceived no changes, and 7 (14.9%) had perceived worsening. The scales that showed the best correlation with patient perception were mJOA (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.25; <em>p</em> <!-->=<!--> <!-->0.002), Nurick (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.19; <em>p</em> <!-->=<!--> <!-->0.009), and NDI (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.17; <em>p</em> <!-->=<!--> <!-->0.016). The definitive MCID thresholds for improvement were an increase in score ≥1.5 points in mJOA, a reduction of ≥0.56 points in the Nurick scale, and a reduction of ≥5 points in NDI. The definitive MCID thresholds for worsening were an increase of ≤0.23 points or a loss of score in mJOA, an increase of ≥0.33 points in the Nurick scale, and an increase of ≥1.26 points in NDI. According to the MCID thresholds, the majority of patients achieved clinically significant improvement: 59.6% in mJOA (compared to 25.5% with worsening), 27.7% in the Nurick scale (compared to 6.4% who worsened), and 42.5% in the NDI (versus 19.1% who worsened).</div></div><div><h3>Conclusion</h3><div>Patient perception of outcome following cervical laminectomy for spondylotic cervical myelopathy significantly correlates with functional scales like mJOA, Nurick, and NDI. The MCID thresholds indicate that patients require a more substantial change to perceive improvement than worsening, highlighting an asymmetry in subjective perception of treatment effects. These findings support using MCID, anchored in subjective perceptions, as a complementary tool to interpret the clinical relevance of quantitati
经过验证的颈椎病(CM)临床量表评估疾病严重程度和治疗效果,但往往无法捕捉患者对治疗效果的主观感知。本研究旨在将CM的常用临床量表与手术治疗后患者感知的结果联系起来。此外,该研究试图建立与患者感知强烈相关的量表的最小临床重要差异(MCID)阈值。患者和方法:一项前瞻性、单中心观察性研究对47例行简单颈椎板切除术的退行性CM患者进行了为期一年的随访。采用mJOA、Nurick、颈椎和肱视觉模拟量表(VAS)、颈部残疾指数(IDC)和EuroQol-5D (EQ5D)对患者进行评估。在术后6个月和1年评估患者对整体效果的感知(PGE),使用锚定问题询问他们是否感觉到改善、恶化或没有变化。MCID采用三种基于锚点的方法计算:平均差、变化差和来自受试者工作特性(COR)曲线的约登指数。结果:随访结束时,25例(53.2%)患者感觉手术后临床改善,15例(31.9%)患者感觉无变化,7例(14.9%)患者感觉病情恶化。与患者知觉相关性最好的量表为mJOA (η2=0.25, p=0.002)、Nurick (η2=0.19, p=0.009)和NDI (η2=0.17, p=0.016)。mJOA评分增加≥1.5分,Nurick评分降低≥0.56分,NDI评分降低≥5分,是mJOA评分改善的确定阈值。mJOA评分增加≤0.23分或丧失评分,Nurick评分增加≥0.33分,NDI评分增加≥1.26分,为mJOA评分恶化的确定阈值。根据MCID阈值,大多数患者获得临床显着改善:mJOA为59.6%(与恶化相比为25.5%),Nurick量表为27.7%(与恶化相比为6.4%),NDI为42.5%(与恶化相比为19.1%)。结论:脊髓型颈椎病患者对颈椎板切除术后预后的感知与mJOA、Nurick和NDI等功能量表显著相关。MCID阈值表明,患者需要更大的变化来感知改善而不是恶化,突出了主观感知治疗效果的不对称性。这些发现支持使用基于主观感知的MCID作为解释临床量表定量变化的临床相关性的补充工具。
{"title":"Patient perception and clinically meaningful change following simple cervical laminectomy for degenerative cervical myelopathy: A prospective cohort study","authors":"Antonio Montalvo-Afonso ,&nbsp;Vicente Martín-Velasco ,&nbsp;Javier Martín-Alonso ,&nbsp;Rubén Diana-Martín ,&nbsp;Jerónimo González-Bernal ,&nbsp;Pedro David Delgado-López","doi":"10.1016/j.neucie.2025.500735","DOIUrl":"10.1016/j.neucie.2025.500735","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Validated clinical scales for cervical myelopathy (CM) assess disease severity and treatment efficacy, but often fail to capture the patient's subjective perception of treatment effects. This study aimed to correlate commonly used clinical scales for CM with patient-perceived outcomes after surgical treatment. Additionally, it sought to establish minimum clinically important difference (MCID) thresholds for scales strongly correlating with patient perception.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patients and methods&lt;/h3&gt;&lt;div&gt;A prospective, single-center observational study followed 47 patients with degenerative CM who underwent simple cervical laminectomy for one year. Patients were assessed using the mJOA, Nurick, cervical and brachial Visual Analogue Scales (VAS), the Neck Disability Index (NDI), and the EuroQol-5D (EQ5D). Patient perception of global effect (PGE) was assessed at 6 months and 1-year post-surgery using an anchor question asking if they perceived improvement, worsening, or no change. MCID was calculated using three anchor-based methods: mean difference, change difference, and the Youden Index from receiver operating characteristic (ROC) curves. Definitive MCID thresholds were the average of these three methods.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;At the end of the follow-up, 25 patients (53.2%) had perceived clinical improvement with surgery, 15 (31.9%) had perceived no changes, and 7 (14.9%) had perceived worsening. The scales that showed the best correlation with patient perception were mJOA (&lt;em&gt;η&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.25; &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.002), Nurick (&lt;em&gt;η&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.19; &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.009), and NDI (&lt;em&gt;η&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.17; &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.016). The definitive MCID thresholds for improvement were an increase in score ≥1.5 points in mJOA, a reduction of ≥0.56 points in the Nurick scale, and a reduction of ≥5 points in NDI. The definitive MCID thresholds for worsening were an increase of ≤0.23 points or a loss of score in mJOA, an increase of ≥0.33 points in the Nurick scale, and an increase of ≥1.26 points in NDI. According to the MCID thresholds, the majority of patients achieved clinically significant improvement: 59.6% in mJOA (compared to 25.5% with worsening), 27.7% in the Nurick scale (compared to 6.4% who worsened), and 42.5% in the NDI (versus 19.1% who worsened).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Patient perception of outcome following cervical laminectomy for spondylotic cervical myelopathy significantly correlates with functional scales like mJOA, Nurick, and NDI. The MCID thresholds indicate that patients require a more substantial change to perceive improvement than worsening, highlighting an asymmetry in subjective perception of treatment effects. These findings support using MCID, anchored in subjective perceptions, as a complementary tool to interpret the clinical relevance of quantitati","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"37 1","pages":"Article 500735"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epileptogenicity post stereoelectroencephalography and subdural grids invasive monitoring: A retrospective analysis of adult and pediatric patients with refractory epilepsy 立体脑电图和硬脑膜下网格侵入性监测后的致痫性:对成人和儿童难治性癫痫患者的回顾性分析。
Pub Date : 2026-01-01 DOI: 10.1016/j.neucie.2025.500703
Sonia Pulido , Sven Ivankovic , Nolan Winslow , Andres Maldonado

Objective

To assess if removal of stereoelectroencephalography (SEEG) or subdural grids (SDG) is associated with an increased seizure frequency in patients with refractory epilepsy during the immediate postoperative period.

Methods

37 patients with refractory epilepsy that underwent monitoring with SEEG or SDG during November 2012–March 2022 were identified using electronic medical records from a single institution. Seizure history, duration of intracranial monitoring, and monitored brain regions were recorded.

Results

5.0% and 5.9% of SEEG and SDG patients had a seizure within 48 h post-termination of monitoring. 25% and 11.8% of SEEG and SDG patients had a seizure between 48 h and 1-week after surgery. Between 1 week and 1 month after SEEG or SDG removal, 35% and 41.2% of patients had a seizure. 30% and 50% SEEG or SDG patients had a seizure between 1- and 2-months following removal. Overall change in postoperative seizure frequency was not significant. Seizure frequency increased for 11.8% of SDG patients while frequency remained unchanged for 5.9% and decreased for 82.4%. No patients post-SEEG removal in our cohort experienced an increased seizure frequency. 95% experienced a decrease in seizure frequency and no change was observed in 5%.

Conclusion

SEEG is not associated with increased epileptogenicity after termination of monitoring. Two patients post-SDG removal experienced an increase in seizure frequency. While patients with refractory epilepsy may continue to have seizures during the immediate postoperative period, it is likely that patients will experience a decrease in seizure frequency after removal of SEEG or SDG.
目的:评估术后立即切除立体脑电图(SEEG)或硬膜下网格(SDG)是否与难治性癫痫患者发作频率增加有关。方法:选取2012年11月至2022年3月期间37例接受SEEG或SDG监测的难治性癫痫患者,使用来自同一机构的电子病历。记录癫痫发作史、颅内监测持续时间及监测的脑区。结果:seg和SDG患者在监测终止后48小时内发生癫痫发作的比例分别为5.0%和5.9%。25%和11.8%的SEEG和SDG患者在术后48小时至1周内发生癫痫发作。在SEEG或SDG切除后1周至1个月,35%和41.2%的患者发生癫痫发作。30%和50%的SEEG或SDG患者在切除后1至2个月发生癫痫发作。术后癫痫发作频率的总体变化不显著。11.8%的SDG患者癫痫发作频率增加,5.9%的患者癫痫发作频率不变,82.4%的患者癫痫发作频率下降。在我们的队列中,没有患者在切除seeg后癫痫发作频率增加。95%的患者癫痫发作频率下降,5%的患者无变化。结论:终止监测后SEEG与癫痫性增加无关。2例患者在sdg移除后癫痫发作频率增加。虽然难治性癫痫患者可能在术后立即继续发作,但在切除SEEG或SDG后,患者的发作频率可能会降低。
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引用次数: 0
Chylous fistula during anterior cervical microdiscectomy: Case report and literature review 颈前路微椎间盘切除术中乳糜瘘:病例报告及文献复习。
Pub Date : 2026-01-01 DOI: 10.1016/j.neucie.2025.500736
Pelayo Hevia-Rodríguez, Laura Panés Laglera, Irati de Goñi García, Fernando Iturbe-Sarmiento, Nicolás Samprón
The anterior approach to the cervical spine is a widely used technique in spinal surgery. Although its most common complications involve vascular, neural, or digestive structures, there is also the potential for injury to lymphatic vessels, which can lead to serious complications if not promptly diagnosed and treated. We present the case of a 70-year-old woman with a history of lumbar arthrodesis and a C5-C6 cervical prosthesis, who underwent an anterior microdiscectomy at C7-T1 via a right-sided approach. During dissection, a dense whitish fluid compatible with chyle was observed, indicating injury to a lymphatic vessel. Ligation with suture was performed and a prevertebral drain was placed. In the postoperative period, the patient developed a mild hematoma in the acromioclavicular region, without cervical collections. The drain was removed after four days of total fasting, followed by the introduction of a low-fat diet. The patient was discharged without complications. After five years of follow-up, no associated complications have been observed. Chyle fistula following anterior cervical discectomy is a rare complication (0.02%) and should be suspected in the presence of milky fluid in the surgical wound, drainage, and/or progressive accumulation. Early diagnosis and appropriate treatment are essential to prevent more severe outcomes. The risk is higher in left-sided approaches near C6 and low right-sided approaches (C7-T1), particularly in the presence of anatomical variants.
颈椎前路入路是脊柱外科中广泛应用的技术。虽然其最常见的并发症涉及血管、神经或消化结构,但也有可能损伤淋巴管,如果不及时诊断和治疗,可能导致严重的并发症。我们报告了一位70岁的女性,她有腰椎关节融合术和C5-C6颈椎假体的病史,她通过右侧入路在C7-T1行前路微椎间盘切除术。在解剖过程中,观察到密集的白色液体与乳糜相容,表明淋巴管损伤。进行缝合结扎并置入椎前引流管。术后患者肩锁区出现轻度血肿,无颈椎积液。经过四天的完全禁食,然后引入低脂饮食,排出的液体被清除。病人出院时无并发症。经过5年的随访,未观察到相关并发症。颈前椎间盘切除术后乳糜瘘是一种罕见的并发症(0.02%),应在手术伤口、引流液和/或进行性积聚中怀疑乳白色液体的存在。早期诊断和适当治疗对于预防更严重的后果至关重要。靠近C6的左侧入路和低右侧入路(C7-T1)的风险更高,特别是在存在解剖变异的情况下。
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引用次数: 0
Global neurosurgery training. Part 1: Skills and challenges for equity 非洲的神经外科培训。第1部分:公平的基本技能和结构性挑战。
Pub Date : 2026-01-01 DOI: 10.1016/j.neucie.2025.500702
María J. García-Rubio , Jose Piquer-Martínez , Jose Piquer-Belloch , Ruben Rodríguez-Mena
Neurosurgery requires rigorous training, yet access remains limited in low-resource countries, particularly in Africa, creating a crisis in specialised care.
This paper, grounded in the principles of global neurosurgery, examines the essential competencies required in neurosurgical training, distinguishing between clinical skills—such as technical proficiency and decision-making—and non-clinical skills, including leadership, emotional management, and communication. Deliberate practice is emphasised as a key methodology for improving skill acquisition through structured repetition, continuous feedback, and expert supervision.
Additionally, the main challenges of specialisation in East Africa are analysed: inadequate infrastructure, overburdened health systems, limited and heterogeneous residency programmes, and a shortage of qualified mentors. Finally, the development of innovative educational strategies is proposed to enhance training in resource-constrained settings and contribute to the sustainable advancement of the specialty.
神经外科手术需要严格的训练,但在资源匮乏的国家,特别是在非洲,获得机会仍然有限,这造成了专科护理的危机。本文以全球神经外科原则为基础,考察了神经外科培训所需的基本能力,区分了临床技能(如技术熟练程度和决策能力)和非临床技能(包括领导能力、情绪管理和沟通能力)。刻意练习是通过结构化的重复、持续的反馈和专家监督来提高技能习得的关键方法。此外,还分析了东非专业化的主要挑战:基础设施不足,卫生系统负担过重,住院医师计划有限且种类繁多,以及缺乏合格的导师。最后,提出了创新教育策略的发展,以加强资源紧张环境下的培训,促进该专业的可持续发展。
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引用次数: 0
期刊
Neurocirugia (English Edition)
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