Pub Date : 2026-01-22DOI: 10.1016/j.neucie.2026.500756
Marta Álvarez González, Javier Robla Costales, Adán González Álvarez, Guadalupe Iglesias Barrero
Gangliogliomas are rare tumors of the central nervous system, representing 1.3% of all brain tumors. Gangliogliomas of the cerebellopontine angle (CPA) are exceptional, and most of them are an exophytic extension of a primary brainstem or cerebellar tumor. We present the case of a 33-year-old man with histologically confirmed CPA ganglioglioma. The tumor was a nodular lesion attached to the 7th and 8th cranial nerves. The resection was complete and the diagnosis was possible only after histopathologic examination of the resected mass. It is necessary to keep in mind these unusual tumors in the differential diagnosis of CPA lesions.
{"title":"Ganglioglioma mimicking a vestibular schwannoma: A rare entity of the cerebellopontine angle.","authors":"Marta Álvarez González, Javier Robla Costales, Adán González Álvarez, Guadalupe Iglesias Barrero","doi":"10.1016/j.neucie.2026.500756","DOIUrl":"10.1016/j.neucie.2026.500756","url":null,"abstract":"<p><p>Gangliogliomas are rare tumors of the central nervous system, representing 1.3% of all brain tumors. Gangliogliomas of the cerebellopontine angle (CPA) are exceptional, and most of them are an exophytic extension of a primary brainstem or cerebellar tumor. We present the case of a 33-year-old man with histologically confirmed CPA ganglioglioma. The tumor was a nodular lesion attached to the 7th and 8th cranial nerves. The resection was complete and the diagnosis was possible only after histopathologic examination of the resected mass. It is necessary to keep in mind these unusual tumors in the differential diagnosis of CPA lesions.</p>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":" ","pages":"500756"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.neucie.2026.500758
Serdar Solmaz, Cafer Ikbal Gulsever
Brain metastases are a frequent complication of advanced non-small cell lung carcinoma (NSCLC), particularly in anaplastic lymphoma kinase (ALK)-positive cases, which show a strong tendency for central nervous system spread. Typically, such metastases demonstrate contrast enhancement on magnetic resonance imaging (MRI) due to disruption of the blood-brain barrier. We report a 45-year-old man with ALK-positive NSCLC presenting with a right temporal swelling and multiple non-contrast-enhancing brain lesions detected before any treatment. The temporal mass was excised and confirmed as metastatic adenocarcinoma. The patient received whole-brain radiotherapy (30Gy in 10 fractions), cisplatin-pemetrexed chemotherapy, and sequential targeted therapy with alectinib and lorlatinib. During three years of follow-up, MRI showed complete resolution of all lesions, and the patient remained neurologically intact and systemically stable. This case underscores the rarity of non-enhancing brain metastases in ALK-positive NSCLC and highlights the importance of recognizing this atypical imaging presentation for timely diagnosis and management.
{"title":"Atypical non-enhancing brain metastases from ALK-positive non-small cell lung carcinoma.","authors":"Serdar Solmaz, Cafer Ikbal Gulsever","doi":"10.1016/j.neucie.2026.500758","DOIUrl":"10.1016/j.neucie.2026.500758","url":null,"abstract":"<p><p>Brain metastases are a frequent complication of advanced non-small cell lung carcinoma (NSCLC), particularly in anaplastic lymphoma kinase (ALK)-positive cases, which show a strong tendency for central nervous system spread. Typically, such metastases demonstrate contrast enhancement on magnetic resonance imaging (MRI) due to disruption of the blood-brain barrier. We report a 45-year-old man with ALK-positive NSCLC presenting with a right temporal swelling and multiple non-contrast-enhancing brain lesions detected before any treatment. The temporal mass was excised and confirmed as metastatic adenocarcinoma. The patient received whole-brain radiotherapy (30Gy in 10 fractions), cisplatin-pemetrexed chemotherapy, and sequential targeted therapy with alectinib and lorlatinib. During three years of follow-up, MRI showed complete resolution of all lesions, and the patient remained neurologically intact and systemically stable. This case underscores the rarity of non-enhancing brain metastases in ALK-positive NSCLC and highlights the importance of recognizing this atypical imaging presentation for timely diagnosis and management.</p>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":" ","pages":"500758"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.neucie.2026.500757
Loreto Esteban Estallo, Amanda Avedillo Ruidiaz, Silvia Vázquez Sufuentes, Miguel Barrera Rojas, David Fustero de Miguel
The persistent trigeminal artery (PTA) is the most frequent embryonic carotid-basilar anastomosis, with an incidence of 0.1-1%. Its coexistence with pituitary adenomas is extremely rare and may pose a significant surgical risk if unrecognized preoperatively. We describe a 58-year-old man incidentally diagnosed with a nonfunctioning pituitary macroadenoma compressing the optic chiasm. Computed tomography angiography demonstrated a PTA in close contact with the tumor's inferior aspect. Endoscopic endonasal resection was performed with neuronavigation and intraoperative Doppler ultrasound, enabling direct visualization and preservation of the artery. A small remnant firmly adherent to the vessel was intentionally left. This case highlights the importance of preoperative identification of vascular variants such as PTA. It also emphasizes the meticulous surgical planning to achieve safe pituitary tumor resection in the presence of high-risk vascular anomalies.
{"title":"Diagnosis and surgical management of a pituitary adenoma coexisting with a persistent trigeminal artery: Case report and review of the literature.","authors":"Loreto Esteban Estallo, Amanda Avedillo Ruidiaz, Silvia Vázquez Sufuentes, Miguel Barrera Rojas, David Fustero de Miguel","doi":"10.1016/j.neucie.2026.500757","DOIUrl":"10.1016/j.neucie.2026.500757","url":null,"abstract":"<p><p>The persistent trigeminal artery (PTA) is the most frequent embryonic carotid-basilar anastomosis, with an incidence of 0.1-1%. Its coexistence with pituitary adenomas is extremely rare and may pose a significant surgical risk if unrecognized preoperatively. We describe a 58-year-old man incidentally diagnosed with a nonfunctioning pituitary macroadenoma compressing the optic chiasm. Computed tomography angiography demonstrated a PTA in close contact with the tumor's inferior aspect. Endoscopic endonasal resection was performed with neuronavigation and intraoperative Doppler ultrasound, enabling direct visualization and preservation of the artery. A small remnant firmly adherent to the vessel was intentionally left. This case highlights the importance of preoperative identification of vascular variants such as PTA. It also emphasizes the meticulous surgical planning to achieve safe pituitary tumor resection in the presence of high-risk vascular anomalies.</p>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":" ","pages":"500757"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.neucie.2025.500738
Luis Ayerbe , Quintí Foguet-Boreu , Ivo Forgnone , María Pérez-Piñar , Rohini Mathur , Salma Ayis
Objectives
Strong evidence on the risk of haemorrhagic strokes for those with psychiatric conditions may lead to more effective interventions for mental health patients and inform future studies. This systematic review aimed to identify all the studies that compare the risk of haemorrhagic stroke for patients with and without depression, anxiety, schizophrenia, bipolar or personality disorders. It also aimed to provide a summary estimate of the risk, where possible, using meta-analysis.
Methods
Electronic searches were conducted in Embase, PsycINFO, PubMED, Scopus and the Web of Science, from database inception to the 11th of March 2025. A Random-effects model to estimate the pooled effect size with 95% confidence intervals was used.
Results
17,214 references were initially identified. Eleven articles were included. Seven of them, five observational and two mendelian randomisation studies, investigated depression. In the meta-analysis depression showed a significant association with an increased risk of haemorrhagic stroke, with pooled HR: 1.28 (1.19–1.38) when only observational studies were included. When mendelian randomisation studies were added the result was a pooled HR: 1.26 (1.08–1.44). The risk of haemorrhagic stroke was increased in one of the three studies that investigated patients with anxiety disorders and in one of the three that looked at patients with schizophrenia. Two studies of bipolar disorder, and one of personality disorders, reported that patients with these conditions do not have an increased risk of haemorrhagic stroke.
Conclusion
Patients with depression have an increased risk of haemorrhagic stroke. The association of mental illness with haemorrhagic stroke needs further research.
目的:关于精神疾病患者出血性中风风险的有力证据可能导致对精神健康患者进行更有效的干预,并为未来的研究提供信息。本系统综述旨在确定所有比较患有和不患有抑郁症、焦虑症、精神分裂症、双相情感障碍或人格障碍患者出血性中风风险的研究。在可能的情况下,它还旨在使用荟萃分析提供风险的汇总估计。方法:在Embase、PsycINFO、PubMED、Scopus和Web of Science中检索自建库至2025年3月11日的文献。采用随机效应模型估计合并效应大小,置信区间为95%。结果:初步鉴定文献17214篇。纳入了11篇文章。其中7项研究,5项观察性研究和2项孟德尔随机研究,调查了抑郁症。在荟萃分析中,抑郁症与出血性卒中风险增加有显著关联,仅纳入观察性研究时,合并HR为1.28(1.19-1.38)。当加入孟德尔随机化研究时,合并风险比为1.26(1.08-1.44)。在调查焦虑症患者的三项研究中的一项和对精神分裂症患者的三项研究中的一项中,出血性中风的风险都有所增加。两项关于双相情感障碍的研究和一项关于人格障碍的研究报告称,患有这些疾病的患者发生出血性中风的风险并没有增加。结论:抑郁症患者发生出血性卒中的风险增加。精神疾病与出血性中风的关系需要进一步研究。
{"title":"Risk of haemorrhagic strokes in patients with psychiatric disorders: A systematic review and meta-analysis","authors":"Luis Ayerbe , Quintí Foguet-Boreu , Ivo Forgnone , María Pérez-Piñar , Rohini Mathur , Salma Ayis","doi":"10.1016/j.neucie.2025.500738","DOIUrl":"10.1016/j.neucie.2025.500738","url":null,"abstract":"<div><h3>Objectives</h3><div>Strong evidence on the risk of haemorrhagic strokes for those with psychiatric conditions may lead to more effective interventions for mental health patients and inform future studies. This systematic review aimed to identify all the studies that compare the risk of haemorrhagic stroke for patients with and without depression, anxiety, schizophrenia, bipolar or personality disorders. It also aimed to provide a summary estimate of the risk, where possible, using meta-analysis.</div></div><div><h3>Methods</h3><div>Electronic searches were conducted in Embase, PsycINFO, PubMED, Scopus and the Web of Science, from database inception to the 11th of March 2025. A Random-effects model to estimate the pooled effect size with 95% confidence intervals was used.</div></div><div><h3>Results</h3><div>17,214 references were initially identified. Eleven articles were included. Seven of them, five observational and two mendelian randomisation studies, investigated depression. In the meta-analysis depression showed a significant association with an increased risk of haemorrhagic stroke, with pooled HR: 1.28 (1.19–1.38) when only observational studies were included. When mendelian randomisation studies were added the result was a pooled HR: 1.26 (1.08–1.44). The risk of haemorrhagic stroke was increased in one of the three studies that investigated patients with anxiety disorders and in one of the three that looked at patients with schizophrenia. Two studies of bipolar disorder, and one of personality disorders, reported that patients with these conditions do not have an increased risk of haemorrhagic stroke.</div></div><div><h3>Conclusion</h3><div>Patients with depression have an increased risk of haemorrhagic stroke. The association of mental illness with haemorrhagic stroke needs further research.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"37 1","pages":"Article 500738"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.neucie.2025.500704
Dario Gagliano , Roberto Manfrellotti , Nikolay Lasunin , Alberto Prats-Galino , Alberto Di Somma , Joaquim Enseñat
Background and objective
Treatment of lesions located within and surrounding the orbit pose considerable surgical challenges, due to the presence of critical neurovascular structures in such deep, confined spaces. Historically, transcranial and craniofacial approaches have been widely used to deal with orbital pathologies. However, in recent decades we have witnessed the emergence of minimally invasive techniques to reduce morbidity and hospitalization times. Among these techniques are the endoscopic endonasal approach (EEA) and the subsequently developed endoscopic transorbital approach (ETOA). This anatomical study aims to compare and combine the surgical view offered by these two endoscopic pathways to achieve a circumferential access to the orbit.
Methods
Anatomic dissections were performed at the Laboratory of Surgical NeuroAnatomy (LSNA) of the Human Anatomy and Embryology Unit, University of Barcelona (Barcelona, Spain) on five cadaveric specimens (10 sides), whose arterial and venous systems were injected with red and blue latex respectively. Dissections were made with microsurgical instruments and a surgical endoscope.
Results
After careful removal of the intraorbital fat, all the extraocular muscles were exposed and dissected, as well as the optic nerve, the ophthalmic artery, and the lacrimal gland. Special emphasis was given to dissecting the nerves’ course from the cavernous sinus to their muscle innervation: oculomotor and its branches, trochlear, abducent and ophthalmic nerve with its branches (frontal, nasociliary and lacrimal nerve). Each of the two endoscopic pathways provided a different perspective of the orbit and its structures. After both corridors were completed, a communication between the surgical pathways was highlighted, in a so-called connection area.
Conclusions
The combination of the EEA and ETOA provides a 360° view of the orbit and its contents. The EEA offers an inferior and medial view of the orbit, through the lamina papyracea of the ethmoid in the first case and through the roof of the maxillary sinus in the latter. At the same time, the ETOA shows a lateral perspective, removing the lateral rim of the orbit, allowing great maneuverability inside the orbit and a wide visualization. This study provides a detailed overview of the surgical neuroanatomy of the orbit, which is an essential and didactic baseline in preparation for practical clinical applications. Overall, EEA and ETOA seem adequate to gain optimal exposure of the orbit and can be adapted to treat a wide range of pathologies. Yet, surgical case series are necessary to establish the true clinical value of these endoscopic approaches in orbital and peri-orbital surgery. However, the limited number of specimens analyzed (5 cadavers, 10 sides) must be acknowledged as a limitation.
{"title":"Endoscopic 360° vision of the orbit: A comparative anatomical study of endonasal and transorbital approaches","authors":"Dario Gagliano , Roberto Manfrellotti , Nikolay Lasunin , Alberto Prats-Galino , Alberto Di Somma , Joaquim Enseñat","doi":"10.1016/j.neucie.2025.500704","DOIUrl":"10.1016/j.neucie.2025.500704","url":null,"abstract":"<div><h3>Background and objective</h3><div>Treatment of lesions located within and surrounding the orbit pose considerable surgical challenges, due to the presence of critical neurovascular structures in such deep, confined spaces. Historically, transcranial and craniofacial approaches have been widely used to deal with orbital pathologies. However, in recent decades we have witnessed the emergence of minimally invasive techniques to reduce morbidity and hospitalization times. Among these techniques are the endoscopic endonasal approach (EEA) and the subsequently developed endoscopic transorbital approach (ETOA). This anatomical study aims to compare and combine the surgical view offered by these two endoscopic pathways to achieve a circumferential access to the orbit.</div></div><div><h3>Methods</h3><div>Anatomic dissections were performed at the Laboratory of Surgical NeuroAnatomy (LSNA) of the Human Anatomy and Embryology Unit, University of Barcelona (Barcelona, Spain) on five cadaveric specimens (10 sides), whose arterial and venous systems were injected with red and blue latex respectively. Dissections were made with microsurgical instruments and a surgical endoscope.</div></div><div><h3>Results</h3><div>After careful removal of the intraorbital fat, all the extraocular muscles were exposed and dissected, as well as the optic nerve, the ophthalmic artery, and the lacrimal gland. Special emphasis was given to dissecting the nerves’ course from the cavernous sinus to their muscle innervation: oculomotor and its branches, trochlear, abducent and ophthalmic nerve with its branches (frontal, nasociliary and lacrimal nerve). Each of the two endoscopic pathways provided a different perspective of the orbit and its structures. After both corridors were completed, a communication between the surgical pathways was highlighted, in a so-called connection area.</div></div><div><h3>Conclusions</h3><div>The combination of the EEA and ETOA provides a 360° view of the orbit and its contents. The EEA offers an inferior and medial view of the orbit, through the lamina papyracea of the ethmoid in the first case and through the roof of the maxillary sinus in the latter. At the same time, the ETOA shows a lateral perspective, removing the lateral rim of the orbit, allowing great maneuverability inside the orbit and a wide visualization. This study provides a detailed overview of the surgical neuroanatomy of the orbit, which is an essential and didactic baseline in preparation for practical clinical applications. Overall, EEA and ETOA seem adequate to gain optimal exposure of the orbit and can be adapted to treat a wide range of pathologies. Yet, surgical case series are necessary to establish the true clinical value of these endoscopic approaches in orbital and peri-orbital surgery. However, the limited number of specimens analyzed (5 cadavers, 10 sides) must be acknowledged as a limitation.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"37 1","pages":"Article 500704"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.neucie.2025.500678
Cristina Sánchez-Viguera , Josep M. Badia
Introduction
Surgical site infections (SSI) are among the most common type of healthcare-associated infections and are involved with an increase in morbidity, mortality and higher healthcare costs.
Methods
The Observatory of Infection in Surgery has conducted a survey to assess the level of awareness and implementation of the preventive measures for SSI. A 64-question questionnaire was given to SENEC (Sociedad Española de Neurocirugía) members.
Results
The survey was answered by 123 neurosurgeons. There is a gap between clinical guidelines and neurosurgery practice (67%), even though neurosurgeons place a high value on international (81.7%) or national (78.7%) clinical guidelines. There are still practices not supported by scientific evidence that some of our respondents follow, including antibiotic prophylaxis ≥ 24 h (10.6%), the habit of not allowing the antiseptic solution to air dry (38.2%) or the use of transparent plastic adhesive drape on the surgical field (77.4%). The most widespread practice for hair management is the selective removal from the surgical area (83.3%). It is most commonly performed by the neurosurgeon himself, in the operating room, which is a significant difference from the use of other surgical specialties (68.5% vs 3.5%, P < .001). There are only 37% of respondents who use alcohol solutions. Double-gloving is utilised by 16.7% of neurosurgeons. The usual use of drainage is quite widespread (60.7%), while the rate of nutritional assessment prior to major surgery is very low (7.5%). Only 37.2% report providing feedback on SSI rates to surgical teams, and a small 16.5% have received specific training programmes on SSI.
Conclusion
Scientific evidence-supported measures are not fully incorporated into neurosurgical practice, and there is a lack of specific training in surgical infection prevention. Additionally, a specific issue has been identified, particularly regarding hair management. Neurosurgeons should actively participate in SSI prevention programmes and analyse the reasons why they do not implement certain strategies into their clinical practice.
手术部位感染(SSI)是最常见的医疗保健相关感染类型之一,涉及发病率、死亡率增加和更高的医疗保健费用。方法:对外科感染观察站进行调查,评估手术感染预防措施的知晓程度和实施情况。向SENEC (Sociedad Española de Neurocirugía)成员发放了一份包含64个问题的问卷。结果:共有123名神经外科医生参与调查。临床指南和神经外科实践之间存在差距(67%),尽管神经外科医生高度重视国际(81.7%)或国家(78,7%)临床指南。我们的一些调查对象仍然遵循一些没有科学证据支持的做法,包括抗生素预防≥24小时(10.6%),不让抗菌溶液风干的习惯(38.2%)或在手术部位使用透明塑料粘合剂(77.4%)。最普遍的毛发管理做法是从手术区域选择性去除毛发(83.3%)。它最常由神经外科医生自己在手术室进行,这与其他外科专业的使用有显著差异(68.5% vs 3.5%, p< 0.001)。只有37%的受访者使用酒精溶液。16.7%的神经外科医生使用双手套。引流术的常规应用相当普遍(66.7%),而大手术前营养评估的比例非常低(7.5%)。只有37.2%的医生报告向外科团队提供了SSI率的反馈,只有16.5%的医生接受了SSI的具体培训计划。结论:科学的循证措施未完全纳入神经外科实践,缺乏外科感染预防的专门培训。此外,一个具体的问题已经确定,特别是关于头发管理。神经外科医生应积极参与SSI预防计划,并分析他们没有在临床实践中实施某些策略的原因。
{"title":"Measures to prevent surgical site infections in neurosurgery: Survey and comparative analysis","authors":"Cristina Sánchez-Viguera , Josep M. Badia","doi":"10.1016/j.neucie.2025.500678","DOIUrl":"10.1016/j.neucie.2025.500678","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical site infections (SSI) are among the most common type of healthcare-associated infections and are involved with an increase in morbidity, mortality and higher healthcare costs.</div></div><div><h3>Methods</h3><div>The Observatory of Infection in Surgery has conducted a survey to assess the level of awareness and implementation of the preventive measures for SSI. A 64-question questionnaire was given to SENEC (Sociedad Española de Neurocirugía) members.</div></div><div><h3>Results</h3><div>The survey was answered by 123 neurosurgeons. There is a gap between clinical guidelines and neurosurgery practice (67%), even though neurosurgeons place a high value on international (81.7%) or national (78.7%) clinical guidelines. There are still practices not supported by scientific evidence that some of our respondents follow, including antibiotic prophylaxis<!--> <!-->≥<!--> <!-->24<!--> <!-->h (10.6%), the habit of not allowing the antiseptic solution to air dry (38.2%) or the use of transparent plastic adhesive drape on the surgical field (77.4%). The most widespread practice for hair management is the selective removal from the surgical area (83.3%). It is most commonly performed by the neurosurgeon himself, in the operating room, which is a significant difference from the use of other surgical specialties (68.5% vs 3.5%, <em>P</em> <!--><<!--> <!-->.001). There are only 37% of respondents who use alcohol solutions. Double-gloving is utilised by 16.7% of neurosurgeons. The usual use of drainage is quite widespread (60.7%), while the rate of nutritional assessment prior to major surgery is very low (7.5%). Only 37.2% report providing feedback on SSI rates to surgical teams, and a small 16.5% have received specific training programmes on SSI.</div></div><div><h3>Conclusion</h3><div>Scientific evidence-supported measures are not fully incorporated into neurosurgical practice, and there is a lack of specific training in surgical infection prevention. Additionally, a specific issue has been identified, particularly regarding hair management. Neurosurgeons should actively participate in SSI prevention programmes and analyse the reasons why they do not implement certain strategies into their clinical practice.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"37 1","pages":"Article 500678"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.neucie.2025.500735
Antonio Montalvo-Afonso , Vicente Martín-Velasco , Javier Martín-Alonso , Rubén Diana-Martín , Jerónimo González-Bernal , Pedro David Delgado-López
<div><h3>Introduction</h3><div>Validated clinical scales for cervical myelopathy (CM) assess disease severity and treatment efficacy, but often fail to capture the patient's subjective perception of treatment effects. This study aimed to correlate commonly used clinical scales for CM with patient-perceived outcomes after surgical treatment. Additionally, it sought to establish minimum clinically important difference (MCID) thresholds for scales strongly correlating with patient perception.</div></div><div><h3>Patients and methods</h3><div>A prospective, single-center observational study followed 47 patients with degenerative CM who underwent simple cervical laminectomy for one year. Patients were assessed using the mJOA, Nurick, cervical and brachial Visual Analogue Scales (VAS), the Neck Disability Index (NDI), and the EuroQol-5D (EQ5D). Patient perception of global effect (PGE) was assessed at 6 months and 1-year post-surgery using an anchor question asking if they perceived improvement, worsening, or no change. MCID was calculated using three anchor-based methods: mean difference, change difference, and the Youden Index from receiver operating characteristic (ROC) curves. Definitive MCID thresholds were the average of these three methods.</div></div><div><h3>Results</h3><div>At the end of the follow-up, 25 patients (53.2%) had perceived clinical improvement with surgery, 15 (31.9%) had perceived no changes, and 7 (14.9%) had perceived worsening. The scales that showed the best correlation with patient perception were mJOA (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.25; <em>p</em> <!-->=<!--> <!-->0.002), Nurick (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.19; <em>p</em> <!-->=<!--> <!-->0.009), and NDI (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.17; <em>p</em> <!-->=<!--> <!-->0.016). The definitive MCID thresholds for improvement were an increase in score ≥1.5 points in mJOA, a reduction of ≥0.56 points in the Nurick scale, and a reduction of ≥5 points in NDI. The definitive MCID thresholds for worsening were an increase of ≤0.23 points or a loss of score in mJOA, an increase of ≥0.33 points in the Nurick scale, and an increase of ≥1.26 points in NDI. According to the MCID thresholds, the majority of patients achieved clinically significant improvement: 59.6% in mJOA (compared to 25.5% with worsening), 27.7% in the Nurick scale (compared to 6.4% who worsened), and 42.5% in the NDI (versus 19.1% who worsened).</div></div><div><h3>Conclusion</h3><div>Patient perception of outcome following cervical laminectomy for spondylotic cervical myelopathy significantly correlates with functional scales like mJOA, Nurick, and NDI. The MCID thresholds indicate that patients require a more substantial change to perceive improvement than worsening, highlighting an asymmetry in subjective perception of treatment effects. These findings support using MCID, anchored in subjective perceptions, as a complementary tool to interpret the clinical relevance of quantitati
{"title":"Patient perception and clinically meaningful change following simple cervical laminectomy for degenerative cervical myelopathy: A prospective cohort study","authors":"Antonio Montalvo-Afonso , Vicente Martín-Velasco , Javier Martín-Alonso , Rubén Diana-Martín , Jerónimo González-Bernal , Pedro David Delgado-López","doi":"10.1016/j.neucie.2025.500735","DOIUrl":"10.1016/j.neucie.2025.500735","url":null,"abstract":"<div><h3>Introduction</h3><div>Validated clinical scales for cervical myelopathy (CM) assess disease severity and treatment efficacy, but often fail to capture the patient's subjective perception of treatment effects. This study aimed to correlate commonly used clinical scales for CM with patient-perceived outcomes after surgical treatment. Additionally, it sought to establish minimum clinically important difference (MCID) thresholds for scales strongly correlating with patient perception.</div></div><div><h3>Patients and methods</h3><div>A prospective, single-center observational study followed 47 patients with degenerative CM who underwent simple cervical laminectomy for one year. Patients were assessed using the mJOA, Nurick, cervical and brachial Visual Analogue Scales (VAS), the Neck Disability Index (NDI), and the EuroQol-5D (EQ5D). Patient perception of global effect (PGE) was assessed at 6 months and 1-year post-surgery using an anchor question asking if they perceived improvement, worsening, or no change. MCID was calculated using three anchor-based methods: mean difference, change difference, and the Youden Index from receiver operating characteristic (ROC) curves. Definitive MCID thresholds were the average of these three methods.</div></div><div><h3>Results</h3><div>At the end of the follow-up, 25 patients (53.2%) had perceived clinical improvement with surgery, 15 (31.9%) had perceived no changes, and 7 (14.9%) had perceived worsening. The scales that showed the best correlation with patient perception were mJOA (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.25; <em>p</em> <!-->=<!--> <!-->0.002), Nurick (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.19; <em>p</em> <!-->=<!--> <!-->0.009), and NDI (<em>η</em><sup>2</sup> <!-->=<!--> <!-->0.17; <em>p</em> <!-->=<!--> <!-->0.016). The definitive MCID thresholds for improvement were an increase in score ≥1.5 points in mJOA, a reduction of ≥0.56 points in the Nurick scale, and a reduction of ≥5 points in NDI. The definitive MCID thresholds for worsening were an increase of ≤0.23 points or a loss of score in mJOA, an increase of ≥0.33 points in the Nurick scale, and an increase of ≥1.26 points in NDI. According to the MCID thresholds, the majority of patients achieved clinically significant improvement: 59.6% in mJOA (compared to 25.5% with worsening), 27.7% in the Nurick scale (compared to 6.4% who worsened), and 42.5% in the NDI (versus 19.1% who worsened).</div></div><div><h3>Conclusion</h3><div>Patient perception of outcome following cervical laminectomy for spondylotic cervical myelopathy significantly correlates with functional scales like mJOA, Nurick, and NDI. The MCID thresholds indicate that patients require a more substantial change to perceive improvement than worsening, highlighting an asymmetry in subjective perception of treatment effects. These findings support using MCID, anchored in subjective perceptions, as a complementary tool to interpret the clinical relevance of quantitati","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"37 1","pages":"Article 500735"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.neucie.2025.500703
Sonia Pulido , Sven Ivankovic , Nolan Winslow , Andres Maldonado
Objective
To assess if removal of stereoelectroencephalography (SEEG) or subdural grids (SDG) is associated with an increased seizure frequency in patients with refractory epilepsy during the immediate postoperative period.
Methods
37 patients with refractory epilepsy that underwent monitoring with SEEG or SDG during November 2012–March 2022 were identified using electronic medical records from a single institution. Seizure history, duration of intracranial monitoring, and monitored brain regions were recorded.
Results
5.0% and 5.9% of SEEG and SDG patients had a seizure within 48 h post-termination of monitoring. 25% and 11.8% of SEEG and SDG patients had a seizure between 48 h and 1-week after surgery. Between 1 week and 1 month after SEEG or SDG removal, 35% and 41.2% of patients had a seizure. 30% and 50% SEEG or SDG patients had a seizure between 1- and 2-months following removal. Overall change in postoperative seizure frequency was not significant. Seizure frequency increased for 11.8% of SDG patients while frequency remained unchanged for 5.9% and decreased for 82.4%. No patients post-SEEG removal in our cohort experienced an increased seizure frequency. 95% experienced a decrease in seizure frequency and no change was observed in 5%.
Conclusion
SEEG is not associated with increased epileptogenicity after termination of monitoring. Two patients post-SDG removal experienced an increase in seizure frequency. While patients with refractory epilepsy may continue to have seizures during the immediate postoperative period, it is likely that patients will experience a decrease in seizure frequency after removal of SEEG or SDG.
{"title":"Epileptogenicity post stereoelectroencephalography and subdural grids invasive monitoring: A retrospective analysis of adult and pediatric patients with refractory epilepsy","authors":"Sonia Pulido , Sven Ivankovic , Nolan Winslow , Andres Maldonado","doi":"10.1016/j.neucie.2025.500703","DOIUrl":"10.1016/j.neucie.2025.500703","url":null,"abstract":"<div><h3>Objective</h3><div>To assess if removal of stereoelectroencephalography (SEEG) or subdural grids (SDG) is associated with an increased seizure frequency in patients with refractory epilepsy during the immediate postoperative period.</div></div><div><h3>Methods</h3><div>37 patients with refractory epilepsy that underwent monitoring with SEEG or SDG during November 2012–March 2022 were identified using electronic medical records from a single institution. Seizure history, duration of intracranial monitoring, and monitored brain regions were recorded.</div></div><div><h3>Results</h3><div>5.0% and 5.9% of SEEG and SDG patients had a seizure within 48<!--> <!-->h post-termination of monitoring. 25% and 11.8% of SEEG and SDG patients had a seizure between 48<!--> <!-->h and 1-week after surgery. Between 1 week and 1 month after SEEG or SDG removal, 35% and 41.2% of patients had a seizure. 30% and 50% SEEG or SDG patients had a seizure between 1- and 2-months following removal. Overall change in postoperative seizure frequency was not significant. Seizure frequency increased for 11.8% of SDG patients while frequency remained unchanged for 5.9% and decreased for 82.4%. No patients post-SEEG removal in our cohort experienced an increased seizure frequency. 95% experienced a decrease in seizure frequency and no change was observed in 5%.</div></div><div><h3>Conclusion</h3><div>SEEG is not associated with increased epileptogenicity after termination of monitoring. Two patients post-SDG removal experienced an increase in seizure frequency. While patients with refractory epilepsy may continue to have seizures during the immediate postoperative period, it is likely that patients will experience a decrease in seizure frequency after removal of SEEG or SDG.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"37 1","pages":"Article 500703"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.neucie.2025.500736
Pelayo Hevia-Rodríguez, Laura Panés Laglera, Irati de Goñi García, Fernando Iturbe-Sarmiento, Nicolás Samprón
The anterior approach to the cervical spine is a widely used technique in spinal surgery. Although its most common complications involve vascular, neural, or digestive structures, there is also the potential for injury to lymphatic vessels, which can lead to serious complications if not promptly diagnosed and treated. We present the case of a 70-year-old woman with a history of lumbar arthrodesis and a C5-C6 cervical prosthesis, who underwent an anterior microdiscectomy at C7-T1 via a right-sided approach. During dissection, a dense whitish fluid compatible with chyle was observed, indicating injury to a lymphatic vessel. Ligation with suture was performed and a prevertebral drain was placed. In the postoperative period, the patient developed a mild hematoma in the acromioclavicular region, without cervical collections. The drain was removed after four days of total fasting, followed by the introduction of a low-fat diet. The patient was discharged without complications. After five years of follow-up, no associated complications have been observed. Chyle fistula following anterior cervical discectomy is a rare complication (0.02%) and should be suspected in the presence of milky fluid in the surgical wound, drainage, and/or progressive accumulation. Early diagnosis and appropriate treatment are essential to prevent more severe outcomes. The risk is higher in left-sided approaches near C6 and low right-sided approaches (C7-T1), particularly in the presence of anatomical variants.
{"title":"Chylous fistula during anterior cervical microdiscectomy: Case report and literature review","authors":"Pelayo Hevia-Rodríguez, Laura Panés Laglera, Irati de Goñi García, Fernando Iturbe-Sarmiento, Nicolás Samprón","doi":"10.1016/j.neucie.2025.500736","DOIUrl":"10.1016/j.neucie.2025.500736","url":null,"abstract":"<div><div>The anterior approach to the cervical spine is a widely used technique in spinal surgery. Although its most common complications involve vascular, neural, or digestive structures, there is also the potential for injury to lymphatic vessels, which can lead to serious complications if not promptly diagnosed and treated. We present the case of a 70-year-old woman with a history of lumbar arthrodesis and a C5-C6 cervical prosthesis, who underwent an anterior microdiscectomy at C7-T1 via a right-sided approach. During dissection, a dense whitish fluid compatible with chyle was observed, indicating injury to a lymphatic vessel. Ligation with suture was performed and a prevertebral drain was placed. In the postoperative period, the patient developed a mild hematoma in the acromioclavicular region, without cervical collections. The drain was removed after four days of total fasting, followed by the introduction of a low-fat diet. The patient was discharged without complications. After five years of follow-up, no associated complications have been observed. Chyle fistula following anterior cervical discectomy is a rare complication (0.02%) and should be suspected in the presence of milky fluid in the surgical wound, drainage, and/or progressive accumulation. Early diagnosis and appropriate treatment are essential to prevent more severe outcomes. The risk is higher in left-sided approaches near C6 and low right-sided approaches (C7-T1), particularly in the presence of anatomical variants.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"37 1","pages":"Article 500736"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.neucie.2025.500702
María J. García-Rubio , Jose Piquer-Martínez , Jose Piquer-Belloch , Ruben Rodríguez-Mena
Neurosurgery requires rigorous training, yet access remains limited in low-resource countries, particularly in Africa, creating a crisis in specialised care.
This paper, grounded in the principles of global neurosurgery, examines the essential competencies required in neurosurgical training, distinguishing between clinical skills—such as technical proficiency and decision-making—and non-clinical skills, including leadership, emotional management, and communication. Deliberate practice is emphasised as a key methodology for improving skill acquisition through structured repetition, continuous feedback, and expert supervision.
Additionally, the main challenges of specialisation in East Africa are analysed: inadequate infrastructure, overburdened health systems, limited and heterogeneous residency programmes, and a shortage of qualified mentors. Finally, the development of innovative educational strategies is proposed to enhance training in resource-constrained settings and contribute to the sustainable advancement of the specialty.
{"title":"Global neurosurgery training. Part 1: Skills and challenges for equity","authors":"María J. García-Rubio , Jose Piquer-Martínez , Jose Piquer-Belloch , Ruben Rodríguez-Mena","doi":"10.1016/j.neucie.2025.500702","DOIUrl":"10.1016/j.neucie.2025.500702","url":null,"abstract":"<div><div>Neurosurgery requires rigorous training, yet access remains limited in low-resource countries, particularly in Africa, creating a crisis in specialised care.</div><div>This paper, grounded in the principles of global neurosurgery, examines the essential competencies required in neurosurgical training, distinguishing between clinical skills—such as technical proficiency and decision-making—and non-clinical skills, including leadership, emotional management, and communication. Deliberate practice is emphasised as a key methodology for improving skill acquisition through structured repetition, continuous feedback, and expert supervision.</div><div>Additionally, the main challenges of specialisation in East Africa are analysed: inadequate infrastructure, overburdened health systems, limited and heterogeneous residency programmes, and a shortage of qualified mentors. Finally, the development of innovative educational strategies is proposed to enhance training in resource-constrained settings and contribute to the sustainable advancement of the specialty.</div></div>","PeriodicalId":74273,"journal":{"name":"Neurocirugia (English Edition)","volume":"37 1","pages":"Article 500702"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}