Differential Diagnosis or Etiology: A Case Report on Amyotrophic Lateral Sclerosis-like Neuropathy Associated with HIV Infection.

IF 0.8 4区医学 Q4 IMMUNOLOGY Current HIV Research Pub Date : 2023-01-01 DOI:10.2174/1570162X21666230914104220

Renato Barradas Rodrigues, Marco Orsini, Sofia Vieira Neves, Wladimir Bocca Vieira de Rezende Pinto, Antônio Marcos da Silva Catarino, Daniel Antunes Pereira, Acary Souza Bulle Oliveira

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Abstract

Background: Retroviruses are described as a risk factor for chronic neuropathy. However, it is still unknown if they can work as amyotrophic lateral sclerosis triggers. Over the years, some cases of this association have been described with heterogenous disclosures.

Case representation: This study aimed to report a case of HIV and ALS-like neuropathy and briefly discuss peculiarities of clinical aspects, such as physiopathology and treatment options. The patient underwent neurological examination associated with blood tests, electromyography, analysis of cerebrospinal fluid, and imaging studies.

Discussion: A non-systematic review was performed in major databases regarding the topic. The case presented mixed upper and lower motor neuron signs and was framed as a probable case of ALS following the present criteria.

Conclusion: After a short follow-up and viral load cleansing, neurological stabilization was achieved.

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鉴别诊断或病因：与 HIV 感染相关的肌萎缩侧索硬化症样神经病的病例报告。

背景：逆转录病毒被描述为慢性神经病变的危险因素。然而，逆转录病毒是否会诱发肌萎缩性脊髓侧索硬化症仍是未知数。多年来，一些与之相关的病例已被描述，但披露的情况各不相同：本研究旨在报告一例艾滋病病毒与 ALS 类似神经病变的病例，并简要讨论临床方面的特殊性，如生理病理和治疗方案。患者接受了神经系统检查、血液检测、肌电图、脑脊液分析和影像学检查：在主要数据库中对该主题进行了非系统性回顾。该病例表现为上运动神经元和下运动神经元混合征象，按照目前的标准，该病例被定为 ALS 的疑似病例：经过短期随访和病毒载量清除后，患者的神经功能趋于稳定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.