{"title":"Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp.","authors":"Hui-Min Wen , Ya-Wen Zhang , Fang-Jian Feng , Guo-Bao Huang , Yu-Han Lv , Zou-Yan Zhang , Li-Jian Ding","doi":"10.1080/10286020.2023.2259317","DOIUrl":null,"url":null,"abstract":"<div><p>Two oxygenated ergostane-type steroids including one new compound, 3<em>β</em>-hydroxy-5<em>α</em>,6<em>β</em>-methoxyergosta-7,22-dien-15-one (<strong>1</strong>) along with a known analogue ergosta-6,22-dien-3<em>β</em>,5<em>α</em>,8<em>α</em>-triol (<strong>2</strong>) were isolated from the crude extracts of the marine sponge-derived fungus <em>Aspergillus</em> sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound <strong>1</strong> was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound <strong>1</strong> exhibited antibacterial activity against <em>Staphylococcus aureus.</em></p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 5","pages":"Pages 548-554"},"PeriodicalIF":1.3000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1028602023002412","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Two oxygenated ergostane-type steroids including one new compound, 3β-hydroxy-5α,6β-methoxyergosta-7,22-dien-15-one (1) along with a known analogue ergosta-6,22-dien-3β,5α,8α-triol (2) were isolated from the crude extracts of the marine sponge-derived fungus Aspergillus sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound 1 was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound 1 exhibited antibacterial activity against Staphylococcus aureus.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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