Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Progress in lipid research Pub Date : 2023-07-01 DOI:10.1016/j.plipres.2023.101241

Xuefeng Jin , Guang-Yu Yang

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引用次数: 1

Abstract

Glycosphingolipids (GSLs) are major amphiphilic glycolipids present on the surface of living cell membranes. They have important biological functions, including maintaining plasma membrane stability, regulating signal transduction, and mediating cell recognition and adhesion. Specific GSLs and related enzymes are abnormally expressed in many cancer diseases and affect the malignant characteristics of tumors. The regulatory roles of GSLs in signaling pathways suggest that they are involved in tumor pathogenesis. GSLs have therefore been widely studied as diagnostic markers of cancer diseases and important targets of immunotherapy. This review describes the tumor-related biological functions of GSLs and systematically introduces recent progress in using diverse GSLs and related enzymes to diagnose and treat tumor diseases. Development of drugs and biomarkers for personalized cancer therapy based on GSL structure is also discussed. These advances, combined with recent progress in the preparation of GSLs derivatives through synthetic biology technologies, suggest a strong future for the use of customized GSL libraries in treating human diseases.

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鞘糖脂在肿瘤诊断和治疗中的病理生理作用和应用

糖鞘脂是存在于活细胞膜表面的主要两亲性糖脂。它们具有重要的生物学功能，包括维持质膜稳定性、调节信号转导、介导细胞识别和粘附。特异性GSL和相关酶在许多癌症疾病中异常表达，并影响肿瘤的恶性特征。GSL在信号通路中的调节作用表明它们参与了肿瘤的发病机制。因此，GSL作为癌症疾病的诊断标志物和免疫疗法的重要靶点已被广泛研究。本文综述了GSL与肿瘤相关的生物学功能，并系统地介绍了利用各种GSL和相关酶诊断和治疗肿瘤疾病的最新进展。还讨论了基于GSL结构的个性化癌症治疗药物和生物标志物的开发。这些进展，再加上通过合成生物学技术制备GSL衍生物的最新进展，表明定制GSL文库在治疗人类疾病方面有着广阔的前景。

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来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.