A Systematic Review and Meta-Analysis of the Prevalence of Triplex Infections (Combined Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus) among Pregnant Women in Nigeria.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY Obstetrics and Gynecology International Pub Date : 2023-01-01 DOI:10.1155/2023/3551297

George Uchenna Eleje, Olabisi Morebise Loto, Hadiza Abdullahi Usman, Chinyere Ukamaka Onubogu, Preye Owen Fiebai, Godwin Otuodichinma Akaba, Ayyuba Rabiu, Ikechukwu Innocent Mbachu, Moriam Taiwo Chibuzor, Rebecca Chinyelu Chukwuanukwu, Ngozi Nneka Joe-Ikechebelu, Emeka Philip Igbodike, Richard Obinwanne Egeonu, Ijeoma Chioma Oppah, Uchenna Chukwunonso Ogwaluonye, Chike Henry Nwankwo, Stephen Okoroafor Kalu, Chisom God'swill Chigbo, Chukwuanugo Nkemakonam Ogbuagu, Shirley Nneka Chukwurah, Chinwe Elizabeth Uzochukwu, Aishat Ahmed, Chiamaka Henrietta Jibuaku, Samuel Oluwagbenga Inuyomi, Bukola Abimbola Adesoji, Ubong Inyang Anyang, Ekene Agatha Emeka, Odion Emmanuel Igue, Ogbonna Dennis Okoro, Prince Ogbonnia Aja, Chiamaka Perpetua Chidozie, Hadiza Sani Ibrahim, Fatima Ele Aliyu, Harrison Chiro Ugwuoroko, Aisha Ismaila Numan, Solace Amechi Omoruyi, Osita Samuel Umeononihu, Chukwuemeka Chukwubuikem Okoro, Ifeanyi Kingsley Nwaeju, Arinze Anthony Onwuegbuna, Lydia Ijeoma Eleje, David Chibuike Ikwuka, Eric Okechukwu Umeh, Sussan Ifeyinwa Nweje, Ifeoma Clara Ajuba, Angela Ogechukwu Ugwu, Uzoamaka Rufina Ebubedike, Divinefavour Echezona Malachy, Chigozie Geoffrey Okafor, Nnaedozie Paul Obiegbu, Emmanuel Onyebuchi Ugwu, Ibrahim Adamu Yakasai, Oliver Chukwujekwu Ezechi, Joseph Ifeanyichukwu Ikechebelu

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Abstract

Objective: We systematically identified the prevalence of triplex infections (combined human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV)) in pregnancy.

Methods: To gather information on the frequency of triplex infections, we searched the databases of PubMed, CINAHL, and Google Scholar. Without regard to language, we utilized search terms that covered HIV, HBV, HCV, and pregnancy. Pregnant women with triplex infections of HIV, HBV, and HCV were included in studies that also examined the prevalence of triplex infections. Review Manager 5.4.1 was employed to conduct the meta-analysis. Critical appraisal and bias tool risk data were provided as percentages with 95% confidence intervals (95% CIs), and I² was used as the statistical measure of heterogeneity. The checklist was created by Hoy and colleagues. The study protocol was registered on PROSPERO, under the registration number CRD42020202583.

Results: Eight studies involving 5314 women were included. We identified one ongoing study. Pooled prevalence of triplex infections was 0.03% (95% CI: 0.02-0.04%) according to meta-analysis. Subgroup analysis demonstrated a significantly high prevalence of 0.08% (95% CI: 0.06-0.10%; 3863 women) in HIV-positive population than 0.00% (95% CI:-0.00-0.00; 1451 women; P < 0.001) in general obstetric population. Moreover, there was a significant difference in the pooled prevalence between studies published between 2001 and 2010 and between 2011 and 2021 (0.14% (95% CI: 0.12 to 0.16 versus 0.03% (95% CI: 0.02 to 0.04%; P < 0.001))) and participants recruited in the period between 2001 and 2011 and between 2012 and 2021 (0.13% (95% CI: 0.05 to 0.21; p=0.002 versus 0.00% (95% CI: -0.00 to 0.00%; p=1.00))), respectively.

Conclusion: The combined prevalence of prenatal triplex infections was 0.03%, with rates notably higher among the group of pregnant women who were HIV-positive and during the recruitment period that took place before 2012. This prevalence still necessitates screening for these infections as necessary.

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尼日利亚孕妇中三联感染(合并人类免疫缺陷病毒、乙型肝炎病毒和丙型肝炎病毒)流行率的系统回顾和荟萃分析

目的:我们系统地确定了妊娠期三联感染(合并人类免疫缺陷病毒(HIV)、乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV))的流行情况。方法:检索PubMed、CINAHL和Google Scholar数据库，收集三联感染的发生频率信息。在不考虑语言的情况下，我们使用了涵盖HIV、HBV、HCV和妊娠的搜索词。HIV、HBV和HCV三重感染的孕妇被纳入研究，这些研究也检查了三重感染的患病率。采用Review Manager 5.4.1进行meta分析。关键评价和偏倚工具风险数据以95%置信区间(95% ci)的百分比形式提供，I2作为异质性的统计度量。这份清单是由霍伊和他的同事创建的。该研究方案已在PROSPERO上注册，注册号为CRD42020202583。结果:纳入了8项研究，涉及5314名女性。我们确定了一项正在进行的研究。根据荟萃分析，三联体感染的总患病率为0.03% (95% CI: 0.02-0.04%)。亚组分析显示患病率显著高，为0.08% (95% CI: 0.06-0.10%;3863名妇女)在hiv阳性人群中的比例比0.00% (95% CI:-0.00-0.00;1451名女性;P < 0.001)。此外，2001年至2010年发表的研究和2011年至2021年发表的研究之间的总患病率存在显著差异(0.14% (95% CI: 0.12至0.16)vs 0.03% (95% CI: 0.02至0.04%;P < 0.001))和2001年至2011年和2012年至2021年期间招募的参与者(0.13% (95% CI: 0.05至0.21;p=0.002 vs . 0.00% (95% CI: -0.00 ~ 0.00%;分别p = 1.00)))。结论:产前三联体感染的总患病率为0.03%，其中hiv阳性孕妇组和2012年以前招募期孕妇的感染率明显较高。这种流行仍然需要在必要时对这些感染进行筛查。

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来源期刊

Obstetrics and Gynecology International OBSTETRICS & GYNECOLOGY-

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

19 weeks

期刊介绍： Obstetrics and Gynecology International is a peer-reviewed, Open Access journal that aims to provide a forum for scientists and clinical professionals working in obstetrics and gynecology. The journal publishes original research articles, review articles, and clinical studies related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, reproductive endocrinology, and sexual medicine.