Ruminococcus gnavus bacteremia: Literature review and a case report associated with acute flare of ulcerative colitis in an immunocompromised patient

IF 2.5 3区生物学 Q3 MICROBIOLOGY Anaerobe Pub Date : 2023-08-01 DOI:10.1016/j.anaerobe.2023.102762

Javier Martínez de Victoria Carazo , David Vinuesa García , Esther Serrano-Conde Sánchez , José Antonio Peregrina Rivas , Antonio José Ruíz Rodríguez , José Hernández Quero

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Abstract

We present a case of bacteremia caused by Ruminococcus gnavus in an immunocompromised patient. R. gnavus is a Gram-positive strict anaerobe bacterium that forms chains. The bacteremia has been associated with an acute flare of ulcerative colitis. Anaerobic bacteremia is becoming increasingly frequent in patients with compromised gastrointestinal barrier. The role of the human microbiota and its alterations in the pathogenesis of immune-related diseases is an expanding area of interest. R. gnavus has been identified as a microorganism that may be responsible for the development of these diseases. The contribution of anaerobic bacteria to the pathogenesis of inflammatory bowel disease (IBD) is discussed, and cases reported up until 2023 were reviewed.

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gnavus瘤胃球菌菌血症：文献综述和一例与免疫功能低下患者溃疡性结肠炎急性发作相关的病例报告。

我们报告了一例由一名免疫功能低下的患者的gnavus瘤胃球菌引起的菌血症。R.gnavus是一种革兰氏阳性的严格厌氧菌，形成链。菌血症与溃疡性结肠炎的急性发作有关。厌氧菌血症在胃肠道屏障受损的患者中越来越常见。人类微生物群及其改变在免疫相关疾病发病机制中的作用是一个越来越受关注的领域。R.gnavus已被鉴定为一种可能导致这些疾病发展的微生物。讨论了厌氧菌在炎症性肠病（IBD）发病机制中的作用，并对截至2023年的病例进行了综述。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.