Seroprevalence of Measles IgG Antibodies in Married Immigrant Women from Multicultural Families in Korea.

IF 2.8 Q2 INFECTIOUS DISEASES Infection and Chemotherapy Pub Date : 2023-09-01 Epub Date: 2023-06-14 DOI:10.3947/ic.2023.0026
Woojoo Lee, Mi Yeong Shin, Eunbyeul Go, Hyun-Cheol Lim, Ji-Yoon Jeon, Yerim Kwon, Yerin Lee, Tong-Soo Kim, Sung-Keun Lee, Young Yil Bahk
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Abstract

Background: Although an effective vaccine has been available, measles still causes mast morbidity and mortality world widely. In Korea, a small number of measles cases have been reported through exposure to imported cases among young people with vaccine-induced measles immunity. Recently due to international migration including marriage, marriage migrants were the second-largest group of foreign population in Korea. Our study was carried out to obtain positive rate of measles antibody among married immigrant women from 12 countries in 10 Gun-Counties and 6 Cities, Korea.

Materials and methods: A total of 547 blood samples were collected from maternal multicultural members from 12 countries. The measles-specific IgG antibody was measured by ELISA (Enzyme-linked immunosorbent assay; Enzygnost® Anti-measles virus/IgG, Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany). We performed a simple logistic regression to test whether the measles antibody seroprevalence differed by participant age, location, or country of birth and then calculated the likelihood ratio statistics to determine whether measles antibody seroprevalence differed by country of birth.

Results: Overall positive measles seroprevalence was 75.3% (95% confidence interval: 71.7 - 78.9). Participants aged 20 - 24 years, 25 - 29 years, and 30 - 63 years has respective seropositivities of 52.5%, 55.3%, and 82.7%. In this study, the geometric mean titers of participants aged 21 - 29 years were slightly lower than those of participants aged over 30 years, which were 1,372 mIU/ml and 2,261 mIU/ml, respectively (average of total participants: 2,027 mIU/ml).

Conclusion: The study provides detailed information about seroimmunity of the married immigrant population in Korea, which is important for measles elimination. Since the 1980s, most vaccine-preventable diseases including measles have been well-controlled. Nevertheless, sporadic measles outbreaks are still reported. Thus, special attention should be paid to the possible importation of infectious diseases such as measles by immigration.

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韩国多文化家庭已婚移民妇女麻疹IgG抗体的血清流行率。
背景:尽管已经有了有效的疫苗,但麻疹仍然会在世界范围内造成严重的发病率和死亡率。在韩国,有少量麻疹病例是通过在具有疫苗诱导的麻疹免疫力的年轻人中接触输入病例报告的。最近,由于包括婚姻在内的国际移民,婚姻移民成为韩国第二大外国人口群体。我们的研究是为了获得来自韩国10个郡和6个城市的12个国家的已婚移民妇女的麻疹抗体阳性率。材料和方法:共从来自12个国家的母亲多元文化成员中采集547份血液样本。麻疹特异性IgG抗体通过ELISA(酶联免疫吸附试验;Enzygnost®抗麻疹病毒/IgG,西门子医疗诊断产品有限公司,德国马尔堡)进行测量。我们进行了简单的逻辑回归,以测试麻疹抗体血清流行率是否因参与者年龄、地点或出生国而异,然后计算似然比统计数据,以确定麻疹抗体血清盛行率是否因出生国而异。结果:麻疹总阳性率为75.3%(95%置信区间:71.7-78.9)。20-24岁、25-29岁和30-63岁的参与者血清阳性率分别为52.5%、55.3%和82.7%。本研究中,21-29岁参与者的几何平均滴度略低于30岁以上参与者,分别为1372mIU/ml和2261mIU/ml(总参与者的平均值:2027mIU/ml)。结论:本研究提供了韩国已婚移民人群血清免疫的详细信息,对消除麻疹具有重要意义。自20世纪80年代以来,包括麻疹在内的大多数疫苗可预防的疾病都得到了很好的控制。尽管如此,仍有零星麻疹爆发的报告。因此,应特别注意移民可能输入麻疹等传染病。
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来源期刊
Infection and Chemotherapy
Infection and Chemotherapy INFECTIOUS DISEASES-
CiteScore
6.60
自引率
11.90%
发文量
71
审稿时长
22 weeks
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