The complement system in preeclampsia: a review of its activation and endothelial injury in the triad of COVID-19 infection and HIV-associated preeclampsia.

IF 2 Q2 OBSTETRICS & GYNECOLOGY Obstetrics and Gynecology Science Pub Date : 2023-07-01 DOI:10.5468/ogs.22175
Mikyle David, Thajasvarie Naicker
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引用次数: 2

Abstract

This review assesses the complement system and its activation, with the pathological features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus (HIV) infection and preeclampsia (PE). The complement system is the first defensive response by the host innate immune system to viral pathogens, including SARS-CoV-2. SARS-CoV-2 entry results in the release of pro-inflammatory cytokines and chemical mediators to create a "cytokine storm". Endothelial cell (EC) dysfunction and cell-mediated injury are also present. These factors cause an exacerbated inflammatory state. During HIV infection and PE, various complement components are elevated, causing a hyper-inflammatory state. Furthermore, EC dysfunction and cell-mediated injury are also present. The similarities in pathological aspects of these three disorders may emanate from excessive complement activation. This review serves as a platform for further research on the complement system, coronavirus disease 2019, HIV infection and PE.

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子痫前期的补体系统:在COVID-19感染和hiv相关子痫前期中其激活和内皮损伤的综述
本文综述了补体系统及其激活、严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)、人类免疫缺陷病毒(HIV)感染和先兆子痫(PE)的病理特征。补体系统是宿主先天免疫系统对包括SARS-CoV-2在内的病毒性病原体的第一个防御反应。SARS-CoV-2进入导致释放促炎细胞因子和化学介质,形成“细胞因子风暴”。内皮细胞(EC)功能障碍和细胞介导的损伤也存在。这些因素导致炎症状态加剧。在HIV感染和PE期间,各种补体成分升高,引起高炎症状态。此外,EC功能障碍和细胞介导的损伤也存在。这三种疾病在病理方面的相似之处可能源于过度的补体激活。本综述为进一步研究补体系统、2019冠状病毒病、HIV感染和PE提供了平台。
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来源期刊
Obstetrics and Gynecology Science
Obstetrics and Gynecology Science Medicine-Obstetrics and Gynecology
CiteScore
3.80
自引率
15.80%
发文量
58
审稿时长
16 weeks
期刊介绍: Obstetrics & Gynecology Science (NLM title: Obstet Gynecol Sci) is an international peer-review journal that published basic, translational, clinical research, and clinical practice guideline to promote women’s health and prevent obstetric and gynecologic disorders. The journal has an international editorial board and is published in English on the 15th day of every other month. Submitted manuscripts should not contain previously published material and should not be under consideration for publication elsewhere. The journal has been publishing articles since 1958. The aim of the journal is to publish original articles, reviews, case reports, short communications, letters to the editor, and video articles that have the potential to change the practices in women''s health care. The journal’s main focus is the diagnosis, treatment, prediction, and prevention of obstetric and gynecologic disorders. Because the life expectancy of Korean and Asian women is increasing, the journal''s editors are particularly interested in the health of elderly women in these population groups. The journal also publishes articles about reproductive biology, stem cell research, and artificial intelligence research for women; additionally, it provides insights into the physiology and mechanisms of obstetric and gynecologic diseases.
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