Klebsiella pneumoniae infection in cynomolgus monkeys at primate research center facility in Indonesia

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES Journal of Medical Primatology Pub Date : 2023-07-31 DOI:10.1111/jmp.12665

Suryo Saputro, Uus Saepuloh, Huda Shalahudin Darusman, Wahyu Putriyani, Permanawati, Ellis Dwi Ayuningsih, Silvia Arin Prabandari, Dyah Setyawati, Joko Pamungkas

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Abstract

Background

Klebsiella pneumoniae infection in nonhuman primates has been widely reported and causes significant morbidity and mortality. Animal deaths occur routinely at the Primate Research Center of IPB University. The results of necropsy and culture suggested a K. pneumoniae infection.

Methods

A mass health assessment of Cynomolgus monkeys (n = 429) was carried out by physical examination and molecular targeting K. pneumoniae (n = 96), family of Coronaviridae (n = 148) and Paramyxoviridae (n = 148).

Results

A total of 49.18% of the animals had clinical symptoms of respiratory disorders, abscesses, trauma, and others. PCR results indicated that 28.57% were positive for K. pneumoniae with 35.71% mortality, while all samples were negative for both virus families.

Conclusions

There have been outbreaks caused by K. pneumoniae and/or K. pneumoniae subsp. pneumoniae. This disease is chronic, infects all of the buildings, and no tendency for disease transmission according to gender and age class.

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印度尼西亚灵长类动物研究中心设施中食蟹猴肺炎克雷伯菌感染。

背景:肺炎克雷伯菌在非人灵长类动物中的感染已被广泛报道，并引起显著的发病率和死亡率。IPB大学灵长类动物研究中心经常发生动物死亡事件。尸检和培养结果提示肺炎克雷伯菌感染。方法:对429只食蟹猴进行体检，并对96只肺炎克雷伯菌、148只冠状病毒科和148只副粘病毒科进行分子靶向检测。结果:49.18%的动物有呼吸系统疾病、脓肿、外伤等临床症状。PCR结果显示，28.57%的标本肺炎克雷伯菌阳性，病死率为35.71%，两科病毒均为阴性。结论:曾发生由肺炎克雷伯菌和/或肺炎克雷伯菌亚种引起的疫情。肺炎。这种疾病是慢性的，感染所有的建筑物，并且没有根据性别和年龄阶层传播疾病的趋势。

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.