Diabetes Mellitus-Mediated MALAT1 Expression Induces Glioblastoma Aggressiveness.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY Turkish neurosurgery Pub Date : 2023-01-01 DOI:10.5137/1019-5149.JTN.41845-22.2

Aysen Akkurt Kocaeli, Secil Ak Aksoy, Melis Ercelik, Gulcin Tezcan, Cagla Tekin, Hasan Kocaeli, Ahmet Bekar, Mevlut Ozgur Taskapilioglu, Sahsine Tolunay, Berrin Tunca

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引用次数: 1

Abstract

Aim: To describe the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in glioblastoma (GB) progression in patients concurrently diagnosed with diabetes mellitus (DM).

Material and methods: Formalin-fixed paraffin-embedded (FFPE) tumor samples of 47 patients diagnosed with GB only and 13 patients diagnosed with GB and DM (GB-DM) were enrolled in this study. Data for p53 and Ki67 immunohistochemical staining of the tumors and blood HbA1c levels of patients with DM were retrospectively collected. MALAT1 expression was assessed using quantitative real-time polymerase chain reaction.

Results: The coexistence of GB and DM induced the nuclear expression of p53 and Ki67 compared with GB only. MALAT1 expression was higher in GB-DM tumors than in GB only tumors. The expression of MALAT1 and HbA1c levels were positively correlated. Additionally, MALAT1 was positively correlated with tumoral p53 and Ki67. The disease-free survival of patients with GB-DM with high MALAT1 expression was shorter than that of those diagnosed with GB only and with a lower MALAT1 expression.

Conclusion: Our findings suggest that one of the mechanisms of the facilitating effect of DM on GB tumor aggressiveness is via MALAT1 expression.

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糖尿病介导的MALAT1表达诱导胶质母细胞瘤侵袭性

目的:探讨转移相关肺腺癌转录本1 (MALAT1)在合并糖尿病(DM)患者胶质母细胞瘤(GB)进展中的作用。材料与方法:选取单纯GB患者47例、GB合并DM (GB-DM)患者13例的福尔马林固定石蜡包埋(FFPE)肿瘤标本。回顾性收集DM患者肿瘤p53、Ki67免疫组化染色及血HbA1c水平。采用实时定量聚合酶链反应检测MALAT1的表达。结果:与单纯GB相比，GB和DM共存可诱导p53和Ki67的核表达。MALAT1在GB- dm肿瘤中的表达高于单纯GB肿瘤。MALAT1的表达与HbA1c水平呈正相关。此外，MALAT1与肿瘤p53和Ki67呈正相关。MALAT1高表达的GB- dm患者的无病生存期比仅诊断为GB且MALAT1低表达的患者短。结论:我们的研究结果提示，DM促进GB肿瘤侵袭性的机制之一是通过MALAT1的表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish neurosurgery 医学-临床神经学

CiteScore

1.50

自引率

12.50%

发文量

126

审稿时长

2 months

期刊介绍： Turkish Neurosurgery is a peer-reviewed, multidisciplinary, open access and totally free journal directed at an audience of neurosurgery physicians and scientists. The official language of the journal is English. The journal publishes original articles in the form of clinical and basic research. Turkish Neurosurgery will only publish studies that have institutional review board (IRB) approval and have strictly observed an acceptable follow-up period. With the exception of reference presentation, Turkish Neurosurgery requires that all manuscripts be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.