Copeptin Reflect Left Ventricular Systolic Function at Early Stage of Acute Myocardial Infarction in a Pig Model.

IF 3.4 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Biomarker Insights Pub Date : 2023-01-01 DOI:10.1177/11772719231171764

Wenjia Li, Wenjian Sun, Liang Lyu, Gang Wang, Weixin Yang, Hongfei An, Liling Chen, Jianhui Fan, Yan Yue, Rongshun Zhang

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Abstract

Introduction: Measurement of biomarkers early after acute myocardial infarction (AMI) might provide a cost-effective and widely available tool to assess infarct severity, myocardial dysfunction, and clinical outcomes. We aimed to induce AMI in miniature pigs, measure the levels of serum biomarkers and global LV function dynamically and explore the release kinetics and optimal sampling time points of copeptin and its correlation with global LV function.

Methods: We induced AMI in the experimental group using a closed-chest model. Left ventricular (LV) function was detected by dual-source computed tomography (DSCT) and serum copeptin was determined by ELISA.

Results: The serum copeptin levels were increased at 1 hour, peaked at 3 hours, gradually decreased after 6 hours, and returned to baseline 3 days after AMI. At 3 to 6 hours, the copeptin cutoff of 16.97 to 17.44 pmol/l had 100% sensitivity and 100% specificity (P ⩽ .001) for AMI. Serum copeptin levels at 3 hours and 3 days were negatively correlated with the 3-hours LVEF (P ⩽ .001), respectively.

Conclusion: Serum copeptin levels change in time, and measurements at 3 to 6 hours after AMI had the highest predictive value.

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Copeptin反映猪急性心肌梗死模型早期左心室收缩功能。

急性心肌梗死(AMI)后早期生物标志物的测量可能为评估梗死严重程度、心肌功能障碍和临床结果提供一种经济有效且广泛可用的工具。本研究旨在诱导小型猪急性心肌梗死，动态测定血清生物标志物水平和整体左室功能，探讨copeptin的释放动力学、最佳采样时间点及其与整体左室功能的相关性。方法:采用闭胸模型对实验组进行AMI诱导。双源计算机断层扫描(DSCT)检测左心室功能，ELISA检测血清copeptin。结果:AMI患者血清copeptin水平在1小时时升高，3小时时达到峰值，6小时后逐渐下降，3天后恢复到基线水平。在3 ~ 6 h时，copeptin的临界值为16.97 ~ 17.44 pmol/l，对AMI具有100%的敏感性和100%的特异性(P < 0.001)。3 h和3 d时血清copeptin水平分别与3 h LVEF呈负相关(P < 0.001)。结论:血清copeptin水平随时间变化，AMI后3 ~ 6小时测定具有最高的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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