Wounding the stroma: Docetaxel's role in dormant breast cancer escape.

IF 7.8 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY PLoS Biology Pub Date : 2023-09-13 eCollection Date: 2023-09-01 DOI:10.1371/journal.pbio.3002297
Tyler T Cooper, Lynne-Marie Postovit
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Abstract

The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. A new study in PLOS Biology reveals that docetaxel-induced injury of tumour stromal cells stimulates the release of cytokines that support dormancy escape of breast cancer cells.

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基质损伤:多西他赛在休眠期乳腺癌症转移中的作用。
休眠期后乳腺癌症复发的机制基础在很大程度上尚未确定。《公共科学图书馆生物学》的一项新研究表明,多西他赛诱导的肿瘤基质细胞损伤刺激细胞因子的释放,这些细胞因子支持癌症细胞休眠期的逃避。
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来源期刊
PLoS Biology
PLoS Biology 生物-生化与分子生物学
CiteScore
14.40
自引率
2.00%
发文量
359
审稿时长
3 months
期刊介绍: PLOS Biology is an open-access, peer-reviewed general biology journal published by PLOS, a nonprofit organization of scientists and physicians dedicated to making the world's scientific and medical literature freely accessible. The journal publishes new articles online weekly, with issues compiled and published monthly. ISSN Numbers: eISSN: 1545-7885 ISSN: 1544-9173
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