Non-Alcoholic Fatty Liver Disease as an Emerging Risk Factor for Heart Failure.

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2023-08-01 Epub Date: 2023-07-04 DOI:10.1007/s11897-023-00613-1
Riccardo M Inciardi, Alessandro Mantovani, Giovanni Targher
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Abstract

Purpose of the review: Non-alcoholic fatty liver disease (NAFLD) and heart failure (HF) are two chronic diseases that have become important global public health problems. This narrative review provides a comprehensive overview of the association between NAFLD and increased risk of new-onset HF, briefly discusses the putative biological mechanisms linking these two conditions, and summarizes targeted pharmacotherapies for NAFLD that might also beneficially affect cardiac complications leading to new-onset HF.

Recent findings: Recent observational cohort studies supported a significant association between NAFLD and the long-term risk of new-onset HF. Notably, this risk remained statistically significant even after adjustment for age, sex, ethnicity, adiposity measures, pre-existing type 2 diabetes and other common cardiometabolic risk factors. In addition, the risk of incident HF was further increased with more advanced liver disease, especially with higher severity of liver fibrosis. There are multiple potential pathophysiological mechanisms by which NAFLD (especially in its more advanced forms) may increase the risk of new-onset HF. Because of the strong link existing between NAFLD and HF, more careful surveillance of these patients will be needed. However, further prospective and mechanistic studies are required to better decipher the existing but complex link between NAFLD and risk of new-onset HF.

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非酒精性脂肪肝是心力衰竭的一个新的危险因素。
综述目的:非酒精性脂肪肝(NAFLD)和心力衰竭(HF)是两种已成为全球重要公共卫生问题的慢性疾病。这篇叙述性综述全面概述了NAFLD与新发HF风险增加之间的关系,简要讨论了将这两种情况联系起来的假定生物学机制,并总结了NAFLD的靶向药物治疗,这些药物治疗也可能有益于影响导致新发性HF的心脏并发症。最近的发现:最近的观察性队列研究支持NAFLD与新发性心衰的长期风险之间的显著关联。值得注意的是,即使在调整了年龄、性别、种族、肥胖指标后,这种风险仍然具有统计学意义,已有的2型糖尿病和其他常见的心脏代谢风险因素。此外,随着肝病的进展,发生HF的风险进一步增加,尤其是肝纤维化的严重程度越高。NAFLD(尤其是更晚期的NAFLD)可能会增加新发HF的风险,这有多种潜在的病理生理机制。由于NAFLD和HF之间存在着密切的联系,需要对这些患者进行更仔细的监测。然而,需要进一步的前瞻性和机制研究来更好地解读NAFLD与新发HF风险之间现有但复杂的联系。
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来源期刊
Current Heart Failure Reports
Current Heart Failure Reports Medicine-Emergency Medicine
CiteScore
5.30
自引率
0.00%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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