Association of ANRIL Gene Single-Nucleotide Polymorphisms With Allergic Rhinitis in Kurdish Population From Kermanshah, Iran.

Sara Falahi, Parisa Feizolahi, Ali Monshizadeh, Zahra Mahmoudi, Jila Mahdavi, Farhad Salari, Ali Gorgin Karaji, Alireza Rezaiemanesh
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Abstract

Background: Allergic rhinitis (AR) is the most common inflammatory disorder of the upper airway caused by aberrant immune responses to allergens in genetically predisposed individuals. Recently, the long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) has been identified as a novel genetic factor associated with increased AR risk.

Objectives: This study aimed to evaluate the potential correlation of ANRIL gene single nucleotide polymorphisms (SNPs) with AR risk in the Kurdish population of Kermanshah, Iran.

Methods: In this case-control study, 130 AR patients and 130 healthy controls were recruited to genotype for two SNPs of the ANRIL gene (rs1333048 and rs10757278) using the Tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) method.

Results: Our results showed no significant difference for the alleles and genotypes frequency distribution of lncRNA ANRIL SNPs (rs1333048 and rs10757278) between AR patients and healthy controls (p > 0.05). Additionally, the dominant, additive and recessive genetic models of both SNPs were not associated with altered susceptibility to AR risk (p > 0.05).

Conclusion: The results demonstrated that the ANRIL gene rs1333048 and rs10757278 polymorphisms might not be associated with susceptibility to AR in the Kurdish population of Kermanshah, Iran.

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伊朗Kermanshah库尔德人群ANRIL基因单核苷酸多态性与变应性鼻炎的关系
背景:变应性鼻炎(AR)是最常见的上呼吸道炎症性疾病,由遗传易感个体对过敏原的异常免疫反应引起。最近,INK4位点(ANRIL)上的长链非编码RNA (lncRNA)反义非编码RNA被发现是与AR风险增加相关的一个新的遗传因素。目的:本研究旨在评估伊朗Kermanshah库尔德人群ANRIL基因单核苷酸多态性(snp)与AR风险的潜在相关性。方法:在本病例对照研究中,招募130例AR患者和130名健康对照者,采用T-ARMS-PCR方法对ANRIL基因rs1333048和rs10757278两个snp进行基因分型。结果:我们的研究结果显示,AR患者与健康对照组的lncRNA ANRIL snp (rs1333048和rs10757278)等位基因和基因型频率分布无显著差异(p > 0.05)。此外,两种snp的显性、加性和隐性遗传模式与AR风险易感性的改变无关(p > 0.05)。结论:伊朗Kermanshah地区库尔德人ANRIL基因rs1333048和rs10757278多态性可能与AR易感性无关。
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