Fungal siderophore metabolism with a focus on Aspergillus fumigatus: impact on biotic interactions and potential translational applications.

IF 5.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Essays in biochemistry Pub Date : 2023-09-13 DOI:10.1042/EBC20220252

Isidor Happacher, Mario Aguiar, Annie Yap, Clemens Decristoforo, Hubertus Haas

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引用次数: 1

Abstract

Iron is an essential trace element that is limiting in most habitats including hosts for fungal pathogens. Siderophores are iron-chelators synthesized by most fungal species for high-affinity uptake and intracellular handling of iron. Moreover, virtually all fungal species including those lacking siderophore biosynthesis appear to be able to utilize siderophores produced by other species. Siderophore biosynthesis has been shown to be crucial for virulence of several fungal pathogens infecting animals and plants revealing induction of this iron acquisition system during virulence, which offers translational potential of this fungal-specific system. The present article summarizes the current knowledge on the fungal siderophore system with a focus on Aspergillus fumigatus and its potential translational application including noninvasive diagnosis of fungal infections via urine samples, imaging of fungal infections via labeling of siderophores with radionuclides such as Gallium-68 for detection with positron emission tomography, conjugation of siderophores with fluorescent probes, and development of novel antifungal strategies.

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真菌铁载体代谢，重点关注烟曲霉：对生物相互作用的影响和潜在的翻译应用。

铁是一种重要的微量元素，在包括真菌病原体宿主在内的大多数栖息地都受到限制。Siderophores是大多数真菌合成的铁螯合剂，用于高亲和力摄取和细胞内处理铁。此外，几乎所有真菌物种，包括那些缺乏铁载体生物合成的真菌物种，似乎都能够利用其他物种产生的铁载体。Siderophore生物合成已被证明对感染动物和植物的几种真菌病原体的毒力至关重要，揭示了在毒力期间这种铁获取系统的诱导，这提供了这种真菌特异性系统的翻译潜力。本文总结了真菌铁载体系统的现有知识，重点介绍了烟曲霉及其潜在的转化应用，包括通过尿液样本对真菌感染的无创诊断、通过用放射性核素（如镓-68）标记铁载体对真菌感染进行成像以进行正电子发射断层扫描检测，铁载体与荧光探针的结合，以及新的抗真菌策略的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Essays in biochemistry 生物-生化与分子生物学

CiteScore

10.50

自引率

0.00%

发文量

105

审稿时长

>12 weeks

期刊介绍： Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immersed in the subject, each article is an up-to-date, self-contained summary of the topic. Bridging the gap between the latest research and established textbooks, Essays in Biochemistry will tell you what you need to know to begin exploring the field, as each article includes the top take-home messages as summary points. Each issue of the journal is guest edited by a key opinion leader in the area, and whether you are continuing your studies or moving into a new research area, the Journal gives a complete picture in one place. Essays in Biochemistry is proud to publish Understanding Biochemistry, an essential online resource for post-16 students, teachers and undergraduates. Providing up-to-date overviews of key concepts in biochemistry and the molecular biosciences, the Understanding Biochemistry issues of Essays in Biochemistry are published annually in October.

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