Asymmetric connections with starburst amacrine cells underlie the upward motion selectivity of J-type retinal ganglion cells.

IF 7.8 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY PLoS Biology Pub Date : 2023-09-18 eCollection Date: 2023-09-01 DOI:10.1371/journal.pbio.3002301
Bo Wang, Yifeng Zhang
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Abstract

Motion is an important aspect of visual information. The directions of visual motion are encoded in the retina by direction-selective ganglion cells (DSGCs). ON-OFF DSGCs and ON DSGCs co-stratify with starburst amacrine cells (SACs) in the inner plexiform layer and depend on SACs for their direction selectivity. J-type retinal ganglion cells (J-RGCs), a type of OFF DSGCs in the mouse retina, on the other hand, do not co-stratify with SACs, and how direction selectivity in J-RGCs emerges has not been understood. Here, we report that both the excitatory and inhibitory synaptic inputs to J-RGCs are direction-selective (DS), with the inhibitory inputs playing a more important role for direction selectivity. The DS inhibitory inputs come from SACs, and the functional connections between J-RGCs and SACs are spatially asymmetric. Thus, J-RGCs and SACs form functionally important synaptic contacts even though their dendritic arbors show little overlap. These findings underscore the need to look beyond the neurons' stratification patterns in retinal circuit studies. Our results also highlight the critical role of SACs for retinal direction selectivity.

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与星突无长突细胞的不对称连接是J型视网膜神经节细胞向上运动选择性的基础。
运动是视觉信息的一个重要方面。视觉运动的方向在视网膜中由方向选择神经节细胞(DSGC)编码。ON-OFF DSGC和ON-DSGC与内部丛状层中的星突无长突细胞(SAC)共同分层,并依赖于SAC的方向选择性。另一方面,J型视网膜神经节细胞(J-RGCs)是小鼠视网膜中的一种OFF DSGC,与SAC不共层,并且J-RGCs中的方向选择性是如何出现的还不清楚。在这里,我们报道了J-RGCs的兴奋性和抑制性突触输入都是方向选择性的(DS),其中抑制性输入在方向选择性中起着更重要的作用。DS抑制输入来自SAC,J-RGCs和SAC之间的功能连接在空间上是不对称的。因此,J-RGCs和SAC形成了功能上重要的突触接触,尽管它们的树突轴几乎没有重叠。这些发现强调了在视网膜回路研究中超越神经元分层模式的必要性。我们的研究结果还强调了SAC对视网膜方向选择性的关键作用。
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来源期刊
PLoS Biology
PLoS Biology 生物-生化与分子生物学
CiteScore
14.40
自引率
2.00%
发文量
359
审稿时长
3 months
期刊介绍: PLOS Biology is an open-access, peer-reviewed general biology journal published by PLOS, a nonprofit organization of scientists and physicians dedicated to making the world's scientific and medical literature freely accessible. The journal publishes new articles online weekly, with issues compiled and published monthly. ISSN Numbers: eISSN: 1545-7885 ISSN: 1544-9173
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