Epigenetics: Novel crucial approach for osteogenesis of mesenchymal stem cells.

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2023-01-01 DOI:10.1177/20417314231175364
Zhaohua Wang, Si Wen, Meiqi Zhong, Ziming Yang, Wei Xiong, Kuo Zhang, Shude Yang, Huizheng Li, Shu Guo
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Abstract

Bone has a robust regenerative potential, but its capacity to repair critical-sized bone defects is limited. In recent years, stem cells have attracted significant interest for their potential in tissue engineering. Applying mesenchymal stem cells (MSCs) for enhancing bone regeneration is a promising therapeutic strategy. However, maintaining optimal cell efficacy or viability of MSCs is limited by several factors. Epigenetic modification can cause changes in gene expression levels without changing its sequence, mainly including nucleic acids methylation, histone modification, and non-coding RNAs. This modification is believed to be one of the determinants of MSCs fate and differentiation. Understanding the epigenetic modification of MSCs can improve the activity and function of stem cells. This review summarizes recent advances in the epigenetic mechanisms of MSCs differentiation into osteoblast lineages. We expound that epigenetic modification of MSCs can be harnessed to treat bone defects and promote bone regeneration, providing potential therapeutic targets for bone-related diseases.

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表观遗传学:间充质干细胞成骨的新关键方法。
骨具有强大的再生潜能,但其修复临界大小骨缺损的能力有限。近年来,干细胞因其在组织工程中的潜力而引起了人们的极大兴趣。应用间充质干细胞(MSCs)促进骨再生是一种很有前途的治疗策略。然而,维持MSCs的最佳细胞功效或活力受到几个因素的限制。表观遗传修饰可以在不改变基因序列的情况下引起基因表达水平的改变,主要包括核酸甲基化、组蛋白修饰和非编码rna。这种修饰被认为是MSCs命运和分化的决定因素之一。了解MSCs的表观遗传修饰可以提高干细胞的活性和功能。本文综述了近年来MSCs向成骨细胞分化的表观遗传机制的研究进展。我们阐述了MSCs的表观遗传修饰可用于治疗骨缺损和促进骨再生,为骨相关疾病提供潜在的治疗靶点。
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
期刊最新文献
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