A plain language summary on assessing the long-term effectiveness of cladribine tablets in people living with relapsing multiple sclerosis: The CLASSIC-MS study.

IF 2.3 Q3 CLINICAL NEUROLOGY Neurodegenerative disease management Pub Date : 2023-10-01 Epub Date: 2023-08-03 DOI:10.2217/nmt-2023-0018
Gavin Giovannoni, Alexey Boyko, Jorge Correale, Gilles Edan, Mark S Freedman, Xavier Montalban, Kottil Rammohan, Dusan Stefoski, Bassem Yamout, Thomas Leist, Aida Aydemir, Laszlo Borsi, Elisabetta Verdun di Cantogno
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Abstract

What is this summary about?: Previous studies have shown that people living with multiple sclerosis (MS) treated with cladribine tablets have fewer relapses (where new symptoms occur or existing symptoms get worse for 24 hours or more) and delayed disability progression (slowing down of the disease getting worse). The CLASSIC-MS study looked at the long-term effectiveness of treatment with cladribine tablets in people living with MS who had taken part in the original CLARITY and CLARITY Extension clinical studies.

What were the results?: Results showed that people treated with cladribine tablets maintained their mobility (the ability to move freely) for longer and experienced other positive effects long after their treatment ended, including being less likely to need further treatment for their MS.

What do the results mean?: The results obtained from CLASSIC-MS show that the benefits of taking cladribine tablets carry on even when patients stop taking the treatment.

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关于评估克拉利宾片对复发性多发性硬化症患者的长期疗效的简明摘要:CLASSIC-MS 研究。
本摘要介绍什么内容:先前的研究表明,接受克拉利宾片治疗的多发性硬化症(MS)患者复发(出现新症状或现有症状恶化达 24 小时或以上)的次数较少,残疾进展(疾病恶化速度减慢)的时间也较短。CLASSIC-MS研究考察了克拉利宾片对参加过最初的CLARITY和CLARITY扩展临床研究的多发性硬化症患者的长期治疗效果:结果表明,接受克拉利宾片治疗的患者在治疗结束后仍能保持较长时间的活动能力(自由行动的能力),并且在治疗结束后的很长一段时间内还能体验到其他积极的效果,包括较少可能需要对其多发性硬化症进行进一步治疗。
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